Immunomodulators are bio-active agents, which suppress, weaken or alter the activity of the immune system. This may consequently weaken inflammatory responses. Immunomodulators (immunosuppreessors) are most often used in organ transplantation to prevent rejection of an implant.

Autoimmune diseases are situations, where the immune system attacks one's own cells, tissues and organs, erroneously recognizing them as alien factors.
Immunomodulators may be used to cure autoimmune deseases.

Bafilomycin B1

Bafilomycin B1
Molecular Formula
C44H65NO13
M.W.
816.00
CAS number
88899-56-3
Source
Streptomyces sp.
Fermentek product Code
BFB-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear yellow solution at 5mg/ml Methanol ;
Clear yellow solution at 5mg/ml DMSO ;
Names and identifiers

Synonyms

  • Hygrolidin, 37-decarboxy-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methyl
  • Setamycin
  • Bafilomycin B1

IUPAC Name

  • (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose

 RTECS: NG8841000

EU number
635-481-1
Chemical name
Bafilomycin B1
Description

Bafilomycin B1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin B1  can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

It displays Antibacterial, Antifungal, Antineoplastic, Immunosuppressive properties.

Bafilomycin B1 shares the same mode of action and activity as its more accessible Bafilomycin A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential antiosteoporotic agent in treating bone lytic diseases.

Bafilomycins have been considered as possible therapeutic agents in the treatment of gastritis.

InChl Key
KFUFLYSBMNNJTF-MZYUNMTESA-N
Canonical SMILES
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C
Isomeric SMILES
C[C@H]1C/C(=C\C=C/[C@@H](C(OC(=O)/C(=C\C(=C/[C@H]([C@H]1O)C)\C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)NC3=C(CCC3=O)O)O)O)OC)/C
Solubility ( literature )

Reportedly soluble in ethanol, methanol, DMF or DMSO. Attention: may form methyl ketal on long term storage in methanol

Compound Classification

Macrolide antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
shipped at ambient temperature. Stored under inert atmosphere.
Retest time
1.5 Years
Applications

Bafilomycins specificly  inhibit  vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms. Bafilomycin A1 is useful in distinguishing among different types of ATPases. Bafilomycin A1 can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. Bafilomycin A1 and B1 significantly attenuate cerebellar granule neuron death resulting from agents that disrupt lysosome. As vacuolar ATPase inhibitors bafilomycins overcome Bcl-​xL-​mediated chemoresistance through restoration of a caspase-​independent apoptotic pathway.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
II or III but basic information is not credible, no quantitative data available
Title
Deleted CAS Numbers
Value
80112-34-1; used with name Setamycin only
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Anti Parasitic
Anti Bacterial
Cancer Related Compounds
Immunomodulators
Research area: Multi-drug resistance
Signal to sort
B

Quote for

Price
$100.00
Bafilomycin_B1.gif
Bafilomycin_B1.gif

Concanamycin A (Folimycin)

Concanamycin A (Folimycin)
Molecular Formula
C46H75NO14
M.W.
866.09
CAS number
80890-47-7
Source
Streptomyces sp.
Fermentek product Code
CON-001
Brand/grade
For research
Appearance
White crystals
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Concamycin A
  • Folimycin
  • Concanamycin

Comment: Many other suppliers, as well as PUBCHEM, CHEMSPIDER and publications, consider Folimycin and Concanamycin A to be synonyms, while SCIFINDER considers these compounds to be different.

IUPAC: 

3-O-(4-O-Carbamoyl-2,6-dideoxy-β-D-arabino-hexopyranosyl)-2,4-dideoxy-1-C-{4-[(4E,6E,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen- 2-yl]-3-hydroxy-2-pentanyl}-4-methyl-5-[(1E)-1-propen-1-yl]-β-D-threo-pentopyranose

RTECS# CB9732000

 

EU number
620-709-4
Chemical name
Concanamycin A
Description

Macrolide type antibiotic, ATPase inhibitor, having antiproliferative, antifungal and antimalarial effects.

InChl Key
DJZCTUVALDDONK-HQMSUKCRSA-N
Canonical SMILES
CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
Isomeric SMILES
CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
Solubility ( literature )

Concanamycin A is reported to be soluble in chloroform, methanol, ethanol, acetone, ethyl acetate, and DMSO.

Concanamycin A is not soluble in water.

 

 

 

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Reportedly, OK to freeze; Frozen stock solutions in DMSO are stable 1 year
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
CN code
Value
--
Title
Depreciated CAS Registry Numbers
Value
66771-59-3
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Angiogenesis related
Apoptosis related
Anti Fungal
Anti Protozoal
Anti Viral
Vasodilator Agents
Anti Tumor agents
Immunomodulators
Research field: Inflamation
Signal to sort
C

Quote for

Price
$100.00
Concanamycin_A.gif
Concanamycin_A.gif

10,11-Dehydrocurvularin

10,11-Dehydrocurvularin
Molecular Formula
C16H18O5
M.W.
290.31
CAS number
21178-57-4
MSDS
Source
Penicillium citrinum
Fermentek product Code
DEH-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-223°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Trans-Dehydrocurvularin
  • Dehydrocurvularin
  • 10,11-dehydrocurvularin
  • alpha,beta-Dehydrocurvularin
  • 1095588-70-7

Comment: There are two CAS Registration numbers, corresponding to the name  Dehydrocurvularin.  1095588-70-7, 21178-57-4 These numbers are not "synonyms." The represent two stereo isomers.

Chemical names: 10,11-Dehydrocurvularin

IUPAC:  (5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione                             

RTECS#

Chemical name
10,11-Dehydrocurvularin
Description

10,11-Dehydrocurvularin is an inhibitor of cell division shown to have antimalarial activity, antibacterial proprerties.

 

InChl Key
AVIRMQMUBGNCKS-RWCYGVJQSA-N
Canonical SMILES
CC1CCCC=CC(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Isomeric SMILES
C[C@H]1CCC/C=C/C(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Compound Classification

Natural antibiotic, anti-bacterial, antifungal, phytotoxic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport.
Fermentek Product Category
Antibiotics
Research field: Cancer
Anti Fungal
Anti Protozoal
Anti Bacterial
Immunomodulators
Research field: Signal Transduction
Signal to sort
D
List price
$5,000.00

Quote for

Price
$1.00
10,11-Dehydrocurvularin
10_11-Dehydrocurvularin
10,11-Dehydrocurvularin
10_11-Dehydrocurvularin

Swainsonine

Swainsonine
Molecular Formula
C8H15NO3
M.W.
173.20
CAS number
72741-87-8
Source
Metharhizium anisopliae
Fermentek product Code
SWA-001
Brand/grade
For research
Appearance
White to beige to slight yellow lyophilizied powder
Purity By TLC
No impurities visible, by multiple methods.
Solubility test
Clear colorless to light yellow solution at 10mg/ml of Water.
Clear colorless to light yellow solution at 5 mg/ml of Methanol
Names and identifiers

Synonyms:

Swainsonine;           

8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;                  

SWAINSONINE;           

Tridolgosir;

 (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol; 

Chemical names:

IUPAC: (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

RTECS# NM2408666

EU number
615-797-6
Description

An indolizidine alkaloid from fungus Metharhizium anisopliae,  a potent alpha-mannosidase inhibitor.

Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.

InChl Key
FXUAIOOAOAVCGD-WCTZXXKLSA-N
Canonical SMILES
C1CC(C2C(C(CN2C1)O)O)O
Isomeric SMILES
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Applications

Swainsonine has a potential for treating cancers such as glioma and gastric carcinoma.
However, a phase II clinical trial of GD0039 (a hydrochloride salt of swainsonine) in 17 patients with renal carcinoma was discouraging.

Swainsonine's activity against tumors is attributed to its stimulation of macrophages.
Swainsonine also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use.
In mice, swainsonine reduces the toxicity of doxorubicin, suggesting that swainsonine might enable use of higher doses of doxorubicin.
Swainsonine may promote restoration of bone marrow damaged by some types of cancer treatments.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Immunomodulators
Others
Signal to sort
S

Quote for

Price
$1.00
Swainsonine.gif
Swainsonine.gif

alpha Zearalanol

alpha Zearalanol
Molecular Formula
C18H26O5
M.W.
322.40
CAS number
26538-44-3
MSDS
Source
Semisynthetic
Fermentek product Code
ZAL-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
180°C-185°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:      Zeranol;    α-Zearalanol; 

Chemical names:   

IUPAC: 6-(6,10-Dihydroxyundecyl)-beta-resorcylic acid, mu-lactone;

RTECS#  DM2520000

EU number
247-769-0
Description

Alpha-Zearalanol is a minor analogue of the zearalenone family of mycotoxins.

InChl Key
DWTTZBARDOXEAM-TZMCWYRMSA-N
Canonical SMILES
CC1CCCC(CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Isomeric SMILES
C[C@@H]1CCC[C@@H](CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Compound Classification

Macrolide.

Mycotoxin - Zearalenone group

Fito-estrogen

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Phytoestrogen alpha-zearalanol  improves vascular function  in  ovariectomized  hyperhomocvsteinemic  rats. 

 

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS Registry Numbers
Value
5975-81-5 | 21307-30-2 | 24507-00-4 | 39487-91-7 | 40036-43-9
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Antibiotics
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Anti Fungal
Immunomodulators
Research field: Signal Transduction
Signal to sort
A

Quote for

Price
$1.00
Alpha_Zearalanol
Alpha_Zearalanol

Destruxin A

Destruxin A
Molecular Formula
C29H47N5O7
M.W.
577.71
CAS number
6686-70-0
Source
Metarhizium anisopliae
Fermentek product Code
DSA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
122°C-128°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane;
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Chemical names:

IUPAC:  (3S,6S,9S,16R,21aS)-16-Allyl-3-[(2S)-2-butanyl]-6-isopropyl-5,8,9-trimethyldodecahydropyrrolo[1,2-d][1,4,7,10,13,16]oxapentaazacyclononadecine-1,4,7,10,14,17(11H,16H)-hexone 

RTECS# HH1500000

EU number
636-280-1
Description

Destruxins are metabolites of a fungus Metarhizium anisopliae. Chemically, these substances are classified as  cyclic hexa-depsipeptides. They posess insecticidal, anti-viral, and phytotoxic propereties. Recently, there is also growing interest in their toxicity to cancer cells.

InChl Key
XIYSEKITPHTMJT-UHFFFAOYSA-N
Canonical SMILES
CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NCCC(=O)OC(C(=O)N2CCCC2C(=O)N1)CC=C)C)C)C(C)C)C
Compound Classification

chemical:

Natural cyclic depsipeptide 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Cancer
Anti Viral
Immunomodulators
Signal to sort
D

Quote for

Price
$1.00
Destruxin_A.gif
Destruxin_A.gif

Enniatin A

Enniatin A
Molecular Formula
C36H63N3O9
M.W.
681.90
CAS number
2503-13-1
Source
Fusarium sp.
Fermentek product Code
ENA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
121°C-125°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

Synonyms:

Chemical names:  Fusafungine ;   Enniatin-A

IUPAC: (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

A Fusarium produced depsipeptide ionophore

RTECS#  

Condensed IUPAC:  cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal]

EU number
215-737-5
Description

Enniatin A is a least abundant commponent of the Enniatin-complex. It has been recently made available as a pure compound, thanks to the most advanced preparative HPLC methods.

InChl Key
TWHBYJSVDCWICV-BHZTXFQCSA-N
Canonical SMILES
CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)CC)C)C(C)C)C(C)CC)C)C(C)C
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)[C@@H](C)CC)C)C(C)C)[C@@H](C)CC)C)C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMSO, DMF.

Compound Classification

Chemical classification:  Cyclic depsipeptide.

Biological classification:

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Natural enniatins occure as a mixture of several related analogs, known as "Enniatins", or "Enniatin complex". 

Enniatins occure in nature in the mycelia of some Fusarium species. Being cyclic and hydrophopic molecules, enniatins are able to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin has not previously been available for investigation.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
2503-13-1; 4530-29-4
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Immunomodulators
Ionophores
Signal to sort
E

Quote for

Price
$1.00
Enniatin_A.gif
Enniatin_A.gif

Rapamycin

Rapamycin
Molecular Formula
C51H79NO13
M.W.
914.17
CAS number
53123-88-9
Source
Streptomyces hygroscopicus subsp hygroscopicus
Fermentek product Code
RAP-001
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
170-185°C
Solubility test
Clear colorless solution at 200mg/ml DMSO
Names and identifiers

Synonyms: RAPA, Rapamune, Sirolimus, RPM, Antibiotic AY 22989

RTECS: VE6250000

EU number
610-965-5
Description

Rapamycin (Sirolimus) is a macrolide compound that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus (Rapamycin) is a potent immunosuppressant. Sirolimus (Rapamycin) possesses both antifungal and antineoplastic properties.

InChl Key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Canonical SMILES
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
Isomeric SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
Solubility ( literature )

Methanol, DMSO

Compound Classification

macrolide immunosuppressor

Storage, handling
-20°C. Protect from light and moisture. Hygroscopic.
Retest time
3 Years
Applications

Research applications: Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Rapamycin Sirolimus inhibits T-lymphocyte activation / proliferation occuring in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressing agents. Sirolimus also inhibits antibody production.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Anti Fungal
Anti Bacterial
Immunomodulators
Signal to sort
R

Quote for

Price
$1.00
Rapamycin.gif
Rapamycin.gif

Neosolaniol

Neosolaniol
Molecular Formula
C19H26O8
M.W.
382.40
CAS number
36519-25-2
MSDS
Source
Fusarium Sporotrichoides
Fermentek product Code
NEO-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
175°C-185°C
Solubility test
Clear colorless solution at 10mg/ml Methanol or DMSO
Names and identifiers

Synonyms:

  • Neosolaniol
  • Solaniol
  • 8-Hydroxydiacetoxyscirpenol
  • Trichothec-9-ene-3-alpha,4-beta,8-alpha,15-tetrol, 12,13-epoxy-, 4,15-diacetate

RTECS: YD0080000

EU number
621-390-4
Description

Type A trichothecene mycotoxin

InChl Key
TVZHDVCTOCZDNE-UHFFFAOYSA-N
Canonical SMILES
CC1=CC2C(CC1O)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification

trichothecene mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

All trichocenes have strong impact on the health due to their immunosuppressive properties

Ingredient type
Fermentek product
Available since
Title
PG
Value
2
Fermentek Product Category
Mycotoxins
Trichocothecenes
Immunomodulators
Signal to sort
N

Quote for

Price
$1.00
Neosolaniol.gif
Neosolaniol.gif

Myriocin

Myriocin
Molecular Formula
C21H39NO6
M.W.
401.54
CAS number
35891-70-4
MSDS
Source
Mycelia sterilia (fungus)
Fermentek product Code
MYR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
164°C-184°C
Solubility test
Clear colorless solution at 2mg/ml of Methanol (slight heating),
Clear colorless solution at 5mg/ml of DMSO (slight heating)
Names and identifiers
  • Myriocin
  • Thermozymocidin,
  • ISP-I
  • (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
EU number
636-862-5
Description

Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer.

InChl Key
ZZIKIHCNFWXKDY-GNTQXERDSA-N
Canonical SMILES
CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O
Isomeric SMILES
CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
Solubility ( literature )

Myriocin is slightly soluble in DMSO, alcohols.Myriocin is insoluble in water and in most organic solvents.

Compound Classification
  • amino-acid antibiotic
  • immunosupressor
  • serine palmitoyltransferase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Myriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids. Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: class 6.1 PG III
Available since
Title
Toxicity oral mouse LD50
Value
300 miligram/kg
Fermentek Product Category
Mycotoxins
Antibiotics
Enzyme-inhibitors
Immunomodulators
Research field: Signal Transduction
Signal to sort
M

Quote for

Price
$1.00
Myriocin.gif
Myriocin.gif
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