Enniatin A

Molecular Formula

C36H63N3O9

M.W.

681.90

CAS number

2503-13-1

Details

Source

Fusarium sp.

Fermentek product Code

ENA-001

Brand/grade

For research

Specifications

Appearance

White to Off-White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

121°C-125°C

Solubility test

Clear colorless solution at 10mg/ml of Dichloromethane or Methanol

Chemical identification

Names and identifiers

Synonyms:

Chemical names: Fusafungine ; Enniatin-A

IUPAC: (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

A Fusarium produced depsipeptide ionophore

RTECS#

Condensed IUPAC: cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal]

EU number

215-737-5

Description

Enniatin A is a least abundant commponent of the Enniatin-complex. It has been recently made available as a pure compound, thanks to the most advanced preparative HPLC methods.

InChl Key

TWHBYJSVDCWICV-BHZTXFQCSA-N

Canonical SMILES

CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)CC)C)C(C)C)C(C)CC)C)C(C)C

Isomeric SMILES

CC[C@H](C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)[C@@H](C)CC)C)C(C)C)[C@@H](C)CC)C)C(C)C

Further Information

Solubility ( literature )

Soluble in ethanol, methanol, DMSO, DMF.

Compound Classification

Chemical classification: Cyclic depsipeptide.

Biological classification:

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Natural enniatins occure as a mixture of several related analogs, known as "Enniatins", or "Enniatin complex".

Enniatins occure in nature in the mycelia of some Fusarium species. Being cyclic and hydrophopic molecules, enniatins are able to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin has not previously been available for investigation.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2015