Swainsonine
Molecular Formula
C8H15NO3
M.W.
173.20
CAS number
72741-87-8
Source
Metharhizium anisopliae
Fermentek product Code
SWA-001
Brand/grade
For research
Appearance
White to beige to slight yellow lyophilizied powder
Purity By TLC
No impurities visible, by multiple methods.
Solubility test
Clear colorless to light yellow solution at 10mg/ml of Water.
Clear colorless to light yellow solution at 5 mg/ml of Methanol
Names and identifiers

Synonyms:

Swainsonine;           

8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;                  

SWAINSONINE;           

Tridolgosir;

 (1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol; 

Chemical names:

IUPAC: (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

RTECS# NM2408666

EU number
615-797-6
Description

An indolizidine alkaloid from fungus Metharhizium anisopliae,  a potent alpha-mannosidase inhibitor.

Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.

InChl Key
FXUAIOOAOAVCGD-WCTZXXKLSA-N
Canonical SMILES
C1CC(C2C(C(CN2C1)O)O)O
Isomeric SMILES
C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Applications

Swainsonine has a potential for treating cancers such as glioma and gastric carcinoma.
However, a phase II clinical trial of GD0039 (a hydrochloride salt of swainsonine) in 17 patients with renal carcinoma was discouraging.

Swainsonine's activity against tumors is attributed to its stimulation of macrophages.
Swainsonine also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use.
In mice, swainsonine reduces the toxicity of doxorubicin, suggesting that swainsonine might enable use of higher doses of doxorubicin.
Swainsonine may promote restoration of bone marrow damaged by some types of cancer treatments.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Signal to sort
S