Swainsonine

Molecular Formula

C8H15NO3

M.W.

173.20

CAS number

72741-87-8

Details

Source

Metharhizium anisopliae

Fermentek product Code

SWA-001

Brand/grade

For research

Specifications

Appearance

White to beige to slight yellow lyophilizied powder

Purity By TLC

No impurities visible, by multiple methods.

Solubility test

Clear colorless to light yellow solution at 10mg/ml of Water.
Clear colorless to light yellow solution at 5 mg/ml of Methanol

Chemical identification

Names and identifiers

Synonyms:

Swainsonine;

8A,B-INDOLIZIDINE-1,2A,8B-TRIOL;

SWAINSONINE;

Tridolgosir;

(1S,2R,8R,8aR)-octahydro-1,2,8-indolizinetriol;

Chemical names:

IUPAC: (1S,2R,8R,8aR)-1,2,3,5,6,7,8,8a-octahydroindolizine-1,2,8-triol

RTECS# NM2408666

EU number

615-797-6

Description

An indolizidine alkaloid from fungus Metharhizium anisopliae, a potent alpha-mannosidase inhibitor.

Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.

InChl Key

FXUAIOOAOAVCGD-WCTZXXKLSA-N

Canonical SMILES

C1CC(C2C(C(CN2C1)O)O)O

Isomeric SMILES

C1C[C@H]([C@@H]2[C@@H]([C@@H](CN2C1)O)O)O

Further Information

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Protect from moisture!

Retest time

3 Years

Applications

Swainsonine has a potential for treating cancers such as glioma and gastric carcinoma.
However, a phase II clinical trial of GD0039 (a hydrochloride salt of swainsonine) in 17 patients with renal carcinoma was discouraging.

Swainsonine's activity against tumors is attributed to its stimulation of macrophages.
Swainsonine also has potential uses as an adjuvant for anti-cancer drugs and other therapies in use.
In mice, swainsonine reduces the toxicity of doxorubicin, suggesting that swainsonine might enable use of higher doses of doxorubicin.
Swainsonine may promote restoration of bone marrow damaged by some types of cancer treatments.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2015