Cyclopamine
Molecular Formula
C27H41NO2
M.W.
411.62
CAS number
4449-51-8
Details
Source
Veratrum californicim (plant extract)
Fermentek product Code
CLP-001
Brand/grade
For research
Specifications
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
224°C-232°C
Solubility test
Clear colorless solution at 5mg/ml DMSO or Methanol
Chemical identification
Names and identifiers
Synonyms: 11-deoxojervine
RTECS: GY0750000
EU number
628-058-8
Description
Cyclopamine is a natural steroidal jerveratrum alkaloide. Cyclopamine is named after its ability to cause cyclopia(holoprosencephaly) in unborn sheep.
InChl Key
QASFUMOKHFSJGL-LAFRSMQTSA-N
Canonical SMILES
CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1
Isomeric SMILES
C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5CC4=C3C)C)O)C)NC1
Further Information
Solubility ( literature )
Insoluble in water. Freely soluble in Chloroform, Dichloromethane.Fairly soluble in benzene, warm (50ºC-60ºC) ethanol (20 mg/mL ), DMSO (4 mg/ml) and DMF (10 mg/mL). May recrystallize from ethanolic solution in cold.
Compound Classification
- Veratrum Alkaloid
- Hh inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications
Known teratogen. Causes damage to embryos. Women who are or may be pregnant should avoid any contact with Cyclopamine
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Fermentek Product Category
Signal to sort
C
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