1-Deoxynojirimycin

Molecular Formula:

C6H13NO4

CAS number:

19130-96-2

EU number:

606-239-2

Fermentek product code:

DNJ

Source:

Mulberry leaves

Brand/grade:

For research

Specifications

Appearance:

White to Off-White powder

Purity by HPLC:

≥98% ; refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Melting point:

195°C-205°C

Solubility test:

Clear colorless solution at 40mg/ml of water, Clear colorless solution at 10mg/ml of DMSO

Chemical identification

Names and identifiers:

Synonyms:

Duvoglustat
Moranolin

Chemical names:

IUPAC: (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol

ECHA: 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-

RTECS#

EU number 606-239-2

Description:

1-Deoxynojirimycin (1-DNJ) is a natural sugar-analogue, which occurs in mulberry leaves. 1-Deoxynojirimycin is a potent α-glucosidase inhibitor exhibiting anti-hyperglycemic, anti-obese, anti-viral and anti-tumor properties.

Molecular weight:

163.17

InChl Key:

LXBIFEVIBLOUGU-JGWLITMVSA-N

Canonical SMILES:

C1C(C(C(C(N1)CO)O)O)O

Isomeric SMILES:

C1[C@@H]([C@H]([C@@H]([C@H](N1)CO)O)O)O

Further Information

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Supply related information

Supply related comments:

Customs: Other Antibiotics-29419000

Shipped at ambient temperature

Shipped in amber-glass vials

Transport safety: Not Dangerous Goods; Not Regulated

Publications

He H, Yu WG, Yang JP, Ge S, Lu YH (2016)
Multiple Comparisons of Glucokinase Activation Mechanisms of Five Mulberry Bioactive Ingredients in Hepatocyte.
Journal of agricultural and food chemistry 64, 2475-2484 [PubMed:26292150]

Tsuduki T, Kikuchi I, Kimura T, Nakagawa K, Miyazawa T (2013)
Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice.
Food chemistry 139, 16-23 [PubMed:23561072]

Chan KC, Lin MC, Huang CN, Chang WC, Wang CJ (2013)
Mulberry 1-deoxynojirimycin pleiotropically inhibits glucose-stimulated vascular smooth muscle cell migration by activation of AMPK/RhoB and down-regulation of FAK.
Journal of agricultural and food chemistry 61, 9867-9875 [PubMed:24050301]

Li YG, Ji DF, Zhong S, Lin TB, Lv ZQ, Hu GY, Wang X (2013)
1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice.
Scientific reports 3, 1377 [PubMed:23536174]

Special Info

Available since:

2021

Other Fields

Title:

Annex III:

Value:

yes

Title:

Pre-registered substances

Title:

Deprecated CAS

Value:

70956-02-4

Title:

add classific.

Value:

anti-HIV agent ; anti-obesity agent ; hepatoprotective agent ; hypoglycemic agent

Title:

add classific.

Value:

EC 3.2.1.20 (α-glucosidase) inhibitor (CHEBI:67239)