* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
RTECS : CB6712200
Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. Exhibits a broad spectrum of pharmacological benefits, such as anticancer, anti-inflammatory, antivirus, antibacterial and hepatoprotective effects. It is used in searching for novel drug applications
An anthraquinone compound from Aloe Vera and other plants.
Aloe-emodin is a drug candidate for cancer therapy.
- It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
- It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
- It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Supply related information
Oncotarget, 2018, Vol 9, (No 25) pp: 17770-17796
Aloe-emodin as drug candidate for cancer therapy
Nadire Ozenver, Mohamed Saeed, Lutfiye Omur Demirezer, Thomas Efferth