Aloe-emodin

Molecular Formula

C15H10O5

M.W.

270.24

CAS number

481-72-1

MSDS

Download

Details

Source

Aloe Vera (extracted from plant)

Fermentek product Code

ALO-001

Brand/grade

For research

Specifications

Appearance

Brownish-orange powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

218°C-225°C

Solubility test

Clear orange solution at 50 mg/ml of DMSO

Chemical identification

Names and identifiers

Synonyms:

* Aloe-emodin
* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
* 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
* 1,8-Dihydroxy-3-hydroxymethylanthraquinone
* 3-Hydroxymethylchrysazin
* Rhabarberone

RTECS : CB6712200

EU number

207-571-7

Description

Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.

InChl Key

YDQWDHRMZQUTBA-UHFFFAOYSA-N

Canonical SMILES

C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO

Further Information

Compound Classification

An anthraquinone compound from Aloe Vera and other plants.

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Aloe-emodin is a drug candidate for cancer therapy.

It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Supply related information

Transport safety: Not Dangerous Goods; Not Regulated

Special Info

Available since