Cylindrospermopsin

Cylindrospermopsin
Molecular Formula
C15H21N5O7S
M.W.
415.40
CAS number
143545-90-8
MSDS
Source
Cyanobacterium: Cylindrospermopsis ovalisporum
Fermentek product Code
CYL
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥ 98% ; refer to CoA for more data
Purity By TLC
≥ 98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 1mg/ml of Methanol.
Names and identifiers

 

Synonyms:

  • Cylindrospermopsin
  • 6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione

 

Chemical names:

IUPAC:  (2aS,3R,4S,5aS,7R)-7-[(R)-(2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)(hydroxy)methyl]-3-methyl-2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylen-4-yl hydrogen sulfate

 

RTECS: UV9104310

 

EU number
802-929-4
Chemical name
Cylindrospermopsine
Description

Tricyclic alkaloid hepatotoxin from a cyanobacterium.

Cylindrospermopsin (abbreviated to CYN, or CYL) is a cyanotoxin produced by a variety of freshwater cyanobacteria. CYL is a polycyclic uracil derivative containing guanidino and sulfate groups. It is also zwitterionic, making it highly water soluble. CYL is toxic to liver and kidney tissue and is thought to inhibit protein synthesis and to covalently modify DNA and/or RNA.

It is not known whether cylindrospermopsin is a carcinogen, but it appears to have no tumour initiating activity in mice. (source: T3DB )

 

 

InChl Key
LHJPHMKIGRLKDR-VDPNAHCISA-N
Canonical SMILES
CC1C(CC2CC(NC3=NCC1N23)C(C4=CC(=O)NC(=O)N4)O)OS(=O)(=O)O
Isomeric SMILES
[C@@]12(C[C@@H]([C@@H]([C@@]3(N1C(N[C@](C2)([C@H](C4=CC(NC(N4)=O)=O)O)[H])=NC3)[H])C)OS(O)(=O)=O)[H]
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to the SDS for further safety and handling instructions
Ingredient type
Fermentek product
Amber-glass vial
Shipped at ambient temperature
Available since
Title
safety sources
Value
Harmful Algae Blooms in Drinking Water: Removal of Cyanobacterial Cells and ... By Harold W. Walker
Title
safety sources
Value
WHO Guidelines for Drinking-water Quality - Cyanobacterial toxins: Cylindrospermopsin
Title
LD50 oral mouse
Value
6 mg/kg
Title
safety sources
Value
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/cylindrospermopsin_508.pdf
Fermentek Product Category
Cyanobacterial Toxins
Research field: Cancer
Protein synthesis inhibitors
Cancer Related Compounds
Research Area: Stem Cells
Signal to sort
C

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Price
$1.00

Aloe-emodin

Aloe-emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
481-72-1
MSDS
Source
Aloe Vera (extracted from plant)
Fermentek product Code
ALO-001
Brand/grade
For research
Appearance
Brownish-orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
218°C-225°C
Solubility test
Clear orange solution at 50 mg/ml of DMSO
Names and identifiers

Synonyms:

* Aloe-emodin
* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
* 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
* 1,8-Dihydroxy-3-hydroxymethylanthraquinone
* 3-Hydroxymethylchrysazin
* Rhabarberone

 

RTECS : CB6712200

 

EU number
207-571-7
Description

Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.

InChl Key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Compound Classification

 An anthraquinone compound from Aloe Vera and other plants.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Aloe-emodin is a drug candidate for cancer therapy.

  • It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
  • It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
  • It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
from RTECS
Value
Mutagen in bacteria and mammalian cell cultures
Fermentek Product Category
Plant-derived
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein kinase related
Cancer Related Compounds
Anti Tumor agents
Research area: Multi-drug resistance
Research Area: Stem Cells
Signal to sort
A

Quote for

Price
$10,000.00
Aloe_Emodin
Aloe_Emodin

17-DMAG-hydrochloride

17-DMAG-hydrochloride
Molecular Formula
C32H48N4O8.HCl
M.W.
653.20
CAS number
467214-21-7
MSDS
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-002
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
215°C-230°C
Solubility test
Clear purple solution at 1mg / ml H2O
Names and identifiers

Synonyms:

  • 17-DMAG HCl
  • Alvespimycin HCl
  • 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride

IUPAC Name:

[(4E,6E,9S,10E,12S,13R,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride

RTECS: LX8922000

 

Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin Hydrochloride
Description

17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.

17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

InChl Key
DFSYBWLNYPEFJK-LYGDSXLOSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Isomeric SMILES
C[C@H]1CC([C@@H]([C@H](/C=C(/[C@@H](C(/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)\C)OC)OC(=O)N)\C)C)O)OC.Cl
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  • Benzoquinone ansamycin class antibiotic
  • Geldanamycin derivate
  • HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

HSP-90 inhibitor; potential anti-cancer drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF​/SF-​mediated Met tyrosine kinase
Title
Target
Value
ATP-​binding site of amino-​terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
HSP90 inhibitors
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
D

Quote for

Price
$10,000.00
17-DMAG_hydrochloride
17-DMAG_hydrochloride

Salinomycin

Salinomycin
Molecular Formula
C42H70O11
M.W.
751.00
CAS number
53003-10-4
MSDS
Source
Streptomyces sp.
Fermentek product Code
SAL-001
Brand/grade
For research
Appearance
White to slightly yellow lyophilizated powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Procoxacin
  • Coxistac
  • Antibiotic 61477

Chemical names:

IUPAC:

(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

RTECS# VO8620000

 
EU number
258-290-1
Chemical name
Salinomycin
Description

A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example  methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. 

As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.

 

 

InChl Key
KQXDHUJYNAXLNZ-XQSDOZFQSA-N
Canonical SMILES
CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O
Isomeric SMILES
CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O
Solubility ( literature )

Reported to be soluble in methanol (10 mg/mL)

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
reach
Value
On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013.
Title
EU Customs Code CN
Value
29419000
Title
Harmonized Tariff Code
Value
294190
Title
general comment
Value
there is Na Salinomycin w cas 55721-31-8
Title
toxicity by RTECS
Value
LD50 oral mouse 50 mg/kg
Title
Deleted CAS Registry Numbers
Value
37362-39-3 ; 50863-72-4
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Protozoal
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Ionophores
Signal to sort
S

Quote for

Price
$20.00
Salinomycin.gif
Salinomycin.gif

Geldanamycin

Geldanamycin
Molecular Formula
C29H40N2O9
M.W.
560.60
CAS number
30562-34-6
MSDS
Source
Streptomyces Hygroscopicus var Geldanus
Fermentek product Code
GEL-001
Brand/grade
For research
Appearance
Yellow solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
Single spot on TLC plates, by multiple methods.
Melting point
260°C-268°C
Crystallinity
Amorphous
Solubility test
Clear yellow solution at 10 mg/ml in DMSO ; Clear yellow solution at 5 mg/ml in Dichloromethane
Names and identifiers

RTECS LX8920000

IUPAC Name : [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate I

Description

Geldanamycin is a benzoquinone ansamycin antibiotic, which binds to Hsp90 (Heat Shock Protein 90) and alters its function. Geldanamycin is a natural product from which several valuable derivates were synthesized. All derivates share its HSP90 inhibition, and vary in overall toxicity and water solubility.

InChl Key
QTQAWLPCGQOSGP-KSRBKZBZSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

Geldanamycin is soluble in DMSO, Dichloromethane. Geldanamycin is insoluble in water.

Compound Classification

Benzoquinone ansamycin antibiotic ;

 

HSP90 inhibitor ;

Tyrosine Kinase Inhibitor ;

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Research fields
Value
Cancer
Fermentek Product Category
Antibiotics
Research field: Cancer
HSP90 inhibitors
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
G

Quote for

Price
$1.00
Geldanamycin.gif
Geldanamycin.gif

17-DMAG

17-DMAG
Molecular Formula
C32H48N4O8
M.W.
616.75
CAS number
467214-20-6
MSDS
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
152°C-162°C
Solubility test
Clear purple solution at 25mg/ml DMSO; Clear purple solution at 10mg/ml Ethanol
Names and identifiers

Synonyms:

  • 17-DMAG
  • Alvespimycin
  • 17-Dimethylaminoethylamino-17-demethoxygeldanamycin

RTECS: LX8922000

 

Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin
Description

17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.

17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

InChl Key
KUFRQPKVAWMTJO-LMZWQJSESA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  • Benzoquinone ansamycin class antibiotic
  • Geldanamycin derivate
  • HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

HSP-90 inhibitor; potential anti-cancer drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF​/SF-​mediated Met tyrosine kinase
Title
Target
Value
ATP-​binding site of amino-​terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
HSP90 inhibitors
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
D

Quote for

Price
$1.00
17-DMAG
17-DMAG

17-AAG

17-AAG (Tanespimycin)
Molecular Formula
C31H43N3O8
M.W.
585.69
CAS number
75747-14-7
Source
Semisynthetic derivate of Geldanamycin
Fermentek product Code
17A-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
200°C-210°C
Solubility test
Clear purple solution at 10mg/ml Methanol
Names and identifiers

Synonyms

  • Tanespimycin
  • 17-(Allylamino)-17-demethoxy- geldanamycin
  • 17AAG

IUPAC name
[(3S,5S,6R,7S,8E,10R,11S,12E,14E)-21-(allylamino)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate

RTECS #
LX8932000

Chemical name
17-Demethoxy-17-allylaminogeldanamycin;
Description

17AAG, also known as "Tanespimycin", is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

17AAG is less hepatotoxic than Geldanamycin.

 

InChl Key
AYUNIORJHRXIBJ-TXHRRWQRSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

DMSO, Methanol. The solubility of 17-AAG in DMSO is >10 mM. General tips for obtaining a higher concentration: Heating to 37°C and using ultrasonic bath is advisable.

Compound Classification
  • Benzoquinone  ansamycin antibiotic.
  • Geldanamycin derivate.
  • HSP90 inhibitor.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

This compound was mentioned as an anticancer medicine. Geldanamycin derivates all interfere with heat-shock proteins, especially HSP90. 17-AAG belongs to a class of drugs called heat shock protein 90 (Hsp90) inhibitors.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
TSE category
Value
S
Title
Transport information
Value
NDG
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Research field: Cancer
HSP90 inhibitors
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
A

Quote for

Price
$1.00
17-AAG__Tanespimycin
17-AAG__Tanespimycin
Subscribe to Research Area: Stem Cells