Protein Synthesis Inhibitors

Cylindrospermopsin

Cylindrospermopsin
Molecular Formula
C15H21N5O7S
M.W.
415.40
CAS number
143545-90-8
MSDS
Source
Cyanobacterium: Cylindrospermopsis ovalisporum
Fermentek product Code
CYL
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥ 98% ; refer to CoA for more data
Purity By TLC
≥ 98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 1mg/ml of Methanol.
Names and identifiers

 

Synonyms:

  • Cylindrospermopsin
  • 6-[(R)-Hydroxy[(2aS,3R,4S,5aS,7R)-2,2a,3,4,5,5a,6,7-octahydro-3-methyl-4-(sulfooxy)-1H-1,8,8b-triazaacenaphthylen-7-yl]methyl]-2,4(1H,3H)-pyrimidinedione

 

Chemical names:

IUPAC:  (2aS,3R,4S,5aS,7R)-7-[(R)-(2,6-Dioxo-1,2,3,6-tetrahydro-4-pyrimidinyl)(hydroxy)methyl]-3-methyl-2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylen-4-yl hydrogen sulfate

 

RTECS: UV9104310

 

EU number
802-929-4
Chemical name
Cylindrospermopsine
Description

Tricyclic alkaloid hepatotoxin from a cyanobacterium.

Cylindrospermopsin (abbreviated to CYN, or CYL) is a cyanotoxin produced by a variety of freshwater cyanobacteria. CYL is a polycyclic uracil derivative containing guanidino and sulfate groups. It is also zwitterionic, making it highly water soluble. CYL is toxic to liver and kidney tissue and is thought to inhibit protein synthesis and to covalently modify DNA and/or RNA.

It is not known whether cylindrospermopsin is a carcinogen, but it appears to have no tumour initiating activity in mice. (source: T3DB )

 

 

InChl Key
LHJPHMKIGRLKDR-VDPNAHCISA-N
Canonical SMILES
CC1C(CC2CC(NC3=NCC1N23)C(C4=CC(=O)NC(=O)N4)O)OS(=O)(=O)O
Isomeric SMILES
[C@@]12(C[C@@H]([C@@H]([C@@]3(N1C(N[C@](C2)([C@H](C4=CC(NC(N4)=O)=O)O)[H])=NC3)[H])C)OS(O)(=O)=O)[H]
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to the SDS for further safety and handling instructions
Ingredient type
Fermentek product
Amber-glass vial
Shipped at ambient temperature
Available since
Title
safety sources
Value
Harmful Algae Blooms in Drinking Water: Removal of Cyanobacterial Cells and ... By Harold W. Walker
Title
safety sources
Value
WHO Guidelines for Drinking-water Quality - Cyanobacterial toxins: Cylindrospermopsin
Title
LD50 oral mouse
Value
6 mg/kg
Title
safety sources
Value
https://ntp.niehs.nih.gov/ntp/htdocs/chem_background/exsumpdf/cylindrospermopsin_508.pdf
Fermentek Product Category
Cyanobacterial Toxins
Research field: Cancer
Protein synthesis inhibitors
Cancer Related Compounds
Research Area: Stem Cells
Signal to sort
C

Quote for

Price
$1.00

Roridin E

Roridin E
Molecular Formula
C29H38O8
M.W.
514.61
CAS number
16891-85-3
MSDS
Source
Myrothecium sp.
Fermentek product Code
ROE
Brand/grade
For research
Purity by HPLC
≥ 98% ; refer to CoA for more data
Purity By TLC
≥ 98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or DMSO
Names and identifiers

Synonyms:

  • Roridin E
  • Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxyethyl)-, (2'E,7'R(R))-

Chemical names:

IUPAC:  Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxyethyl)-, (2'E,7'R(R))-(1R,3R,8R,12E,17R,18E,20Z,24R,25S,26S)-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,12,18,20-tetraene-26,2'-oxirane]-11,22-dione

T3DB: T3D3711

RTECS# YX9821500

Description

Roridin E is trichothecene toxin produced by molds from Fusarium, Myrothecium, and Stachybotrys genera. 

InChl Key
KEEQQEKLEZRLDS-FLGSVKSYSA-N
Canonical SMILES
CC1=CC2C3(CC1)COC(=O)C=C(CCOC(C=CC=CC(=O)OC4C3(C5(CO5)C(C4)O2)C)C(C)O)C
Isomeric SMILES
CC1=C[C@@H]2[C@@]3(CC1)COC(=O)/C=C(/CCO[C@H](/C=C/C=C\C(=O)O[C@H]4[C@]3([C@]5(CO5)[C@@H](C4)O2)C)[C@@H](C)O)\C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Shipped at ambient temperature
Available since
Fermentek Product Category
Food Safety
Mycotoxins
Trichocothecenes
Cytotoxic agents
Apoptosis related
Protein synthesis inhibitors
Protein kinase related
Anti Parasitic
Anti Viral
Signal to sort
R

Quote for

Price
$1.00
RORIDIN E
RORIDIN E

Fidaxomicin

Fidaxomicin
Molecular Formula
C52H74Cl2O18
M.W.
1 058.00
CAS number
873857-62-6
MSDS
Source
Dactylosporangium aurantiacum (An Actinobecterium)
Fermentek product Code
FID-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-170°C
Solubility test
Clear colorless to faint yellow solution at 1mg/ml of DMSO;
Clear colorless to faint yellow solution at 5 mg/ml of Methanol
Names and identifiers

Synonyms:

  • Dificid,
  • Dificlir, 
  • Clostomicin B1,
  • lipiarmicin,
  • lipiarmycin,
  • lipiarmycin A3, 
  • tiacumicin B

Chemical names:

IUPAC:   [(2R,3S,4S,5S,6R)-6-[[(3E,5E,8S,9E,11S,12R,13E,15E,18S)-12-[(2R,3S,4R,5S)-3,4-dihydroxy-6,6-dimethyl-5-(2-methylpropanoyloxy)oxan-2-yl]oxy-11-ethyl-8-hydroxy-18-[(1R)-1-hydroxyethyl]-9,13,15-trimethyl-2-oxo-1-oxacyclooctadeca-3,5,9,13,15-pentaen-3-yl]methoxy]-4-hydroxy-5-methoxy-2-methyloxan-3-yl] 3,5-dichloro-2-ethyl-4,6-dihydroxybenzoate

RTECS#  Not available

EU number
692-555-6
Chemical name
Fidaxomicin
Description

Fidaxomicin is a narrow spectrum macrocyclic antibiotic, sourced from actinomycete Dactylosporangium aurantiacum. Fidaxomicin is non-systemic, meaning it is minimally absorbed into the bloodstream. This anti-bacterial agent  selectively acts against pathogenic Clostridium difficile bacteria which may infect the colon, while causing minimal damage to the natural intestinal microbial flora.

InChl Key
ZVGNESXIJDCBKN-UUEYKCAUSA-N
Canonical SMILES
CCC1C=C(C(CC=CC=C(C(=O)OC(CC=C(C=C(C1OC2C(C(C(C(O2)(C)C)OC(=O)C(C)C)O)O)C)C)C(C)O)COC3C(C(C(C(O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)C
Isomeric SMILES
CC[C@H]1/C=C(/[C@H](C/C=C/C=C(/C(=O)O[C@@H](C/C=C(/C=C(/[C@@H]1O[C@H]2[C@H]([C@H]([C@@H](C(O2)(C)C)OC(=O)C(C)C)O)O)\C)\C)[C@@H](C)O)\CO[C@H]3[C@H]([C@H]([C@@H]([C@H](O3)C)OC(=O)C4=C(C(=C(C(=C4O)Cl)O)Cl)CC)O)OC)O)\C
Solubility ( literature )

Reportedly, Fidaxomicin is soluble in CHCl3(10 mg/ml), methanol(10 mg/ml), DMSO(1mg/ml); poor water solubility.

Compound Classification

UNSPSC:

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
depreciated CAS
Value
55352-58-4, 56645-60-4, 750595-89-2
Fermentek Product Category
Antibiotics
Cytotoxic agents
Protein synthesis inhibitors
Anti Bacterial
Research field: Signal Transduction
Signal to sort
F

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Price
$1.00

Leptomycin A

Leptomycin A
Molecular Formula
C32H46O6
M.W.
526.70
CAS number
87081-36-5
Source
Streptomyces sp
Fermentek product Code
LPA-001
Brand/grade
For research
Appearance
Lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Antibiotic ATS 1287A
  • Antibiotic PD 118607
  • Jildamycin

Chemical names:

  • Jildamycin
  • Leptomycin A

IUPAC:

(2E,10E,12E,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid

RTECS#: RA5391000

EU number
N.A.
Description

Unsaturated Fatty Acid polyketide with cytotoxic activity. Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.

InChl Key
QECBVZBMGUAZDL-SJMSETAHSA-N
Canonical SMILES
CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
Isomeric SMILES
CC1C=CC(=O)OC1/C=C/C(=C\C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Fermentek Product Category
Antibiotics
Protein synthesis inhibitors
Anti Fungal
Anti Tumor agents
Others
Signal to sort
L

Quote for

Price
$100.00
Leptomycin_A.gif
Leptomycin_A.gif

Enniatin (complex)

Enniatin (complex)
Molecular Formula
C33H57N3O9
M.W.
639.80
CAS number
11113-62-5
Source
Fusarium sp
Fermentek product Code
ENC-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% as complex ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane
or Methanol
Names and identifiers

Synonyms:
Enniatins

Chemical names:
Enniatin complex;

IUPAC:
4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

RTECS : n.a.
 

 

Description

Enniatins are a family of depsipeptides produced by several species of Fusaria. Enniatins have initially been shown to act as ionophores. Later, their effects on acyl-CoA cholesterol transferase, ABC-transporters and the selectivity of their antitumor action are emphasized in the research.

InChl Key
MIZMDSVSLSIMSC-OGLSAIDSSA-N
Canonical SMILES
CC(C)[C@H]1C(=O)OC(C(=O)N([C@H](C(=O)OC(C(=O)N([C@H](C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Compound Classification

Depsipeptide antibiotic.

Ammonium Ionophore.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Mentioned as a replacement for Nonactin, in manufacturing on ammonium specific electrodes.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Cancer
Protein synthesis inhibitors
Anti Protozoal
Ionophores
Signal to sort
E

Quote for

Price
$1.00
Enniatin__complex_.gif
Enniatin__complex_.gif

Virginiamycin S1

Virginiamycin S1
Molecular Formula
C43H49N7O10
M.W.
823.89
CAS number
23152-29-6
Source
Streptomyces virginiae
Fermentek product Code
VIS-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
222°C-235°C
Solubility test
Clear colorless solution at 5 mg/ml of Dichloromethane
Names and identifiers
  • Staphylomycin S
  • N-(3-Hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L- prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2- phenylglycine rho-lactone
EU number
245-462-6
Description

Cyclic polypeptide antibiotic Virginiamycin S1 is a major component of virginiamycin complex, which is used in veterynary medicine to treat Gram-positive infections, and as a growth promoter in young swine and cattle. 

Virginiamycin is originated in Streptomyces virginiae, but also other strains of streptomycettes. Virginiamycin S1 is a cyclic polypeptide antibiotic, of Streptogramin group B class. Reportedly, it targets the 60S ribosomal protein L37 affecting translation, ribosomal structure. It binds to the 23S rRNA

InChl Key
FEPMHVLSLDOMQC-CPKGNLGUSA-N
Canonical SMILES
CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C
Isomeric SMILES
CC[C@H]1C(=O)N2CCC[C@@H]2C(=O)N([C@@H](C(=O)N3CCC(=O)C[C@H]3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C
Solubility ( literature )

Virginiamycin S1 is soluble in ethanol, methanol, DMSO, Dichloromethane, DMF, and sparingly, in water .

Compound Classification

Cyclic peptide antibiotic, Streptogramin group

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein synthesis inhibitors
Signal to sort
V

Quote for

Price
$1.00
Virginiamycin_S1.gif
Virginiamycin_S1.gif

Thiostrepton

Thiostrepton
Molecular Formula
C72H85N19O18S5
M.W.
1 664.89
CAS number
1393-48-2
MSDS
Source
Streptomyces laurentii
Fermentek product Code
TIS-001
Brand/grade
For research
Appearance
White to off-white powder
slightly yellowish cast may be observed on the solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
>210°C (decomposition, not melting.)
Solubility test
Clear colorless solution at 5mg/ml DMSO or Chloroform
Names and identifiers

Synonyms:  Alaninamide, Bryamycin , Thiactin
RTECS      :   XN6300100

EU number
215-734-9
Description

Thiostrepton is a broad spectrum polypeptide antibiotic which targets a wide range of gram positive and gram negative bacteria.

InChl Key
NSFFHOGKXHRQEW-DVRIZHICSA-N
Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Isomeric SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C\C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Solubility ( literature )

Thiostrepton is soluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. It may be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected from light.

Compound Classification

Polypeptide antibiotic
Antimicrobial

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Thiostrepton is used as a reagent for both positive and negative selection of genes involved in nucleotide metabolism. Thiostrepton is highly active against gram-positive bacteria. In its crude form, Thiostrepton is used in veterinary medicine, in mastitis caused by gram-negative organisms and in dermatologic disorders. inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2).

As an antitumoragent Thiostrepton induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. Thiostrepton is a FoxM1 specific inhibitor.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
Change notif 23-Jule-2018
Value
Updated storage condition
Title
update 22-Jan-2019
Value
minor update, shipment conditions
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gram/kg
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein synthesis inhibitors
Anti Bacterial
Cancer Related Compounds
Research field: Signal Transduction
Signal to sort
T

Quote for

Price
$1.00
Thiostrepton.gif
Thiostrepton.gif

Leptomycin B

Leptomycin B
Molecular Formula
C33H48O6
M.W.
540.70
CAS number
87081-35-4
Source
Streptomyces sp.
Fermentek product Code
LPB-001
Brand/grade
For research
Appearance
Lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: 

  • Elactocin
  • Mantuamycin
  • Antibiotic CI 940
  • Antibiotic CL 1957A

RTECS:      RA5390000

EU number
617-954-4
Description

Leptomycin B is an unsaturated, branched-chain fatty acid.

Until 4-jun-2018 Leptomycin had been offered by Fermentek in the form of 1% V/W solution in Methanol/Water mix. Since then, it is offered as lyophylizate.

InChl Key
YACHGFWEQXFSBS-XYERBDPFSA-N
Canonical SMILES
CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
Isomeric SMILES
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
Solubility ( literature )

Leptomycin B is soluble in ethanol, methanol.

Until 4-jun-2018, Fermentek supplied Leptomycin in form of 1% w/v solution in Methanol/water. Since 4-jun-2018 it is as a lyophylisate. 

Compound Classification

Fatty acid antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Retest time
2 Years
Applications

Leptomycin B is an important tool in the study of nuclear export. Leptomycin B is twice as potent as Leptomycin A Leptomycin B (LPB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp. However, recent data (2003) showed that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors. Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
94730-69-5
Title
Change notif 4-jun-2018
Value
Supplied as lyophilisate
Title
comments: safety
Value
The info regarding toxicity/flammability is about the methanol. We offer solid material.
Fermentek Product Category
Research field: Cancer
Protein synthesis inhibitors
Anti Fungal
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
L

Quote for

Price
$1.00
Leptomycin_B.gif
Leptomycin_B.gif

Diacetoxyscirpenol (DAS)

Diacetoxyscirpenol (DAS)
Molecular Formula
C19H26O7
M.W.
366.41
CAS number
2270-40-8
Source
Fusarium sp
Fermentek product Code
DAS-001
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-165°C
Solubility test
Clear colorless solution at 10mg/ml Methanol ; Clear colorless solution at 10mg/ml dichloromethane
Names and identifiers

Synonyms

  • Anguidine,
  • DAS
  • Diacetoxyscirpenol

RTECS YD0112000

 

EU number
218-873-3
Description

Diacetoxyscirpenol (DAS) also known as Anguidine,  is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins.

 DAS inhibits initiation of protein synthesis, causing the death of intensively replicating cells. By the virtue of this effect, DAS possesses teratogenic and anti proliferatory properties. Consequently,  DAS attracts interest as a potential cancer- drug.

 

 

InChl Key
AUGQEEXBDZWUJY-ZLJUKNTDSA-N
Canonical SMILES
CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H]([C@H]([C@H]([C@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification
  • trichothecene mycotoxin
  • Apoptosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
11011-10-2 ; 22135-66-6 ; 25662-95-7 ; 28776-47-8 ; 109547-11-7 ; 145427-91-4 ; 852223-87-1 ;
Title
Transport information
Value
Pg II
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Regulated Mycotoxins
Trichocothecenes
Research field: Cancer
Apoptosis related
Protein synthesis inhibitors
Signal to sort
D

Quote for

Price
$1.00
Diacetoxyscirpenol.gif
Diacetoxyscirpenol.gif

Deoxynivalenol

Deoxynivalenol (DON)
Molecular Formula
C15H20O6
M.W.
296.30
CAS number
51481-10-8
MSDS
Source
Semisynthetic
Fermentek product Code
DON-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
150°C-155°C
Solubility test
Clear colorless solution at 10mg/ml Methanol or Ethyl acetate

Names and identifiers
  • Rd toxin
  • Vomitoxin
  • Deoxynivalenol
  • 4-Deoxynivalenol
  • Dehydronivalenol
  • 4-Desoxynivalenol

RTECS YD0167000

EU number
610-668-0
Description

Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.

InChl Key
LINOMUASTDIRTM-QGRHZQQGSA-N
Canonical SMILES
CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO
Solubility ( literature )

Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.

Compound Classification

trichothecene type B mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
50722-37-7 ; 115825-61-1 ; 1394244-12-2
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Trichocothecenes
Enzyme-inhibitors
Protein synthesis inhibitors
DNA replication inhibitors
Immunosupressors
Immunomodulators
Signal to sort
D

Quote for

Price
$1.00
Deoxynivalenol.gif
Deoxynivalenol.gif
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