Protein Synthesis Inhibitors

Brefeldin A

Brefeldin A
Molecular Formula
C16H24O4
M.W.
280.36
CAS number
20350-15-6
Source
Eupenicillium brefeldianum
Fermentek product Code
BRF-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
198°C-215°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol
Names and identifiers

Synonyms:

  •         Nectrolide;
  •         Synergisidin;
  •         Cyanaein;
  •         Ascotoxin
  •         Cyanein
  •         Decumbin
  •         Brefeldin A

EC# :     606-528-3

 Systematic name:

(1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

RTECS: GY8410000

EU number
606-528-3
Description

Brefeldin A is a macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.

InChl Key
KQNZDYYTLMIZCT-HHMYAMTESA-N
Canonical SMILES
CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
Isomeric SMILES
C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C\C(=O)O1)O)O
Solubility ( literature )

Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate

Compound Classification
  • Macrocyclic lactone antibiotic.
  • Antifungal
  • Antiviral
  • Protein Synthesis Inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus.
Inhibitor of intracellular protein transport and protein secretionA macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotAnimal

No animal ingredients

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
sig
Value
203729
Title
TSE
Value
F
Signal to sort
B

Borrelidin

Borrelidin
Molecular Formula
C28H43NO6
M.W.
489.64
CAS number
7184-60-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
BOR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
106°C-114°C
Solubility test
Clear colorless solution at 10 mg/ml of Methanol or DMSO or Chloroform
Names and identifiers
  • Treponemycin
  • Cyclopentanecarboxylic acid
  • 2-[(4E,6E)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
  • RTECS ED8750000
EU number
811-923-0
Description

Borrelidin is a macrolide-polyketide antibiotic displaying anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties.

InChl Key
OJCKRNPLOZHAOU-UGKRXNSESA-N
Canonical SMILES
CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
Isomeric SMILES
C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C
Solubility ( literature )

Borrelidin is soluble in DMF, DMSO, Ethanol, Ethyl acetate, Methanol

Compound Classification
  • Cyclin-dependent kinase (CDK) inhibitor ;
  • Antiviral agent
  • Anti- Angiogenetic agent
  • Apoptosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Applications

Borrelidin, a potent antifungal agent

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
1403-11-8; 97328-74-0
Title
Transport information
Value
Not hazardous for transport
Title
Inhibitor of:
Value
threonyl aminoacyl-tRNA synthetase; cyclin-dependent kinase (CDK).
Signal to sort
B

Anisomycin

Anisomycin
Molecular Formula
C14H19NO4
M.W.
265.30
CAS number
22862-76-6
Source
Streptomyces griseolus
Fermentek product Code
ANI-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
139°C-145°C
Solubility test
Clear colorless solution at 10mg/ml Ethyl Acetate
Names and identifiers

Synonyms : Flagecidin

IUPAC Name: [(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] acetate

EU number
245-269-7
Description

Anisomycin is a protein synthesis inhibitor. It binds to the 60S ribosomal subunits and prevents the formation of peptide bond, and consequently, the chain elongation.

InChl Key
YKJYKKNCCRKFSL-RDBSUJKOSA-N
Canonical SMILES
CC(=O)OC1C(CNC1CC2=CC=C(C=C2)OC)O
Isomeric SMILES
CC(=O)O[C@@H]1[C@H](CN[C@@H]1CC2=CC=C(C=C2)OC)O
Solubility ( literature )

Anisomycin is soluble in DMSO, Ethyl-Acetate, Dichloromethane. Slightly soluble in water

Compound Classification

Biological action classification

  • Protein Synthesis Inhibitor
  • Nucleic Acid Synthesis Inhibitor

Chemical classification

  • Pyrrolinin class antibiotic
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Originally discovered by Sobin and Tanner in 1954, Anisomycin was identified as an antibiotic active against protozoa such as Trichomonas and fungi and yeasts, and was considered as a potential human anti-candidal and anti-amoebic drug. Sobin, B. A., and F. W. Tanner, Jr. 1954. Anisomycin, a new antiprotozoa antibiotic. J. Am. Chem. Soc. 76:4053. As such, Anisomycin was put by GONZALEZ CONSTANDSE to clinical trials in 1955: Anisomycin in intestinal amebiasis; study of 30 clinical casesPrensa Med Mex. 1956 Sep-Dec;21(7-10):114-5 Anisomycin is also proposed as a potential psychiatric drug, as it is shown to affect protein synthesis an Amygdala, a brain part involved in memory(1). The earliest usage of Anisomycin in research on memory biochemistry was made by Jonec and Walsterlain in 1979 . Again, this property of Anisomycin is ascribed to its ability to inhibit protein synthesis. Effect of inhibitors of protein synthesis on the development of kindled seizures in rats.Jonec V, Walsterlain CG.Exp Neurol. 1979 Dec;66(3):524-32 Recently, publications appear showing the immunomodulating properties on Anisomycin. This discovery leads to researches on the potential use of Anisomycin in transplantation: Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice.Xing F et al,J Immunother. 2008 Nov-Dec;31(9):858-70 In the field of cell-signaling research, Anisomycin is used as an activator of kinase cascades in mammalian cells, especially the stress-activated Protein Kinase (SAPK2/p38MAPK) and p46/54JNK Anisomycin is a selective ingredientof Martin Lewis Agar, a bacteriological solid medium used for isolation of pathogenic Neisseria species. Martin, J. E., Jr., and J. S. Lewis. 1977. Anisomycin: improved antimycotic activity in modified Thayer-Martin medium. Public Health Lab. 35:53-62

Disclaimer
For Research use only
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG III
Title
tse
Value
P
Signal to sort
A