- 2-[(4E,6E)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
Borrelidin is a macrolide-polyketide antibiotic displaying anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties.
Borrelidin is soluble in DMF, DMSO, Ethanol, Ethyl acetate, Methanol
- Cyclin-dependent kinase (CDK) inhibitor ;
- Antiviral agent
- Anti- Angiogenetic agent
- Apoptosis inducer
Borrelidin, a potent antifungal agent
THE JOURNAL OF BIOLOGICAL CHEMISTRY
Vol. 280, No. 1, Issue of January 7, pp. 571–577, 2005
A Unique Hydrophobic Cluster Near the Active Site Contributes to Differences in Borrelidin Inhibition among Threonyl-tRNA Synthetases
Dieter Soll at al
Potent angiogenesis inhibitors derived from borrelidin: SAR and antitumor activities.
Barrie Wilkinson, Steven J. Moss, Isabelle Carletti, William Vousden, Nigel Coates, Carlos Olano, Rose M. Sheridan, Carmen Méndez, Jóse A. Salas, Peter F. Leadlay and Ming-Qiang Zhang
DOI: Published April 2006