Brefeldin A

Molecular Formula

C16H24O4

M.W.

280.36

CAS number

20350-15-6

Details

Source

Eupenicillium brefeldianum

Fermentek product Code

BRF-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

198°C-215°C

Solubility test

Clear colorless solution at 10 mg/ml Methanol

Chemical identification

Names and identifiers

Synonyms:

Nectrolide;
Synergisidin;
Cyanaein;
Ascotoxin
Cyanein
Decumbin
Brefeldin A

EC# : 606-528-3

Systematic name:

(1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

RTECS: GY8410000

EU number

606-528-3

Description

Brefeldin A is a macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.

InChl Key

KQNZDYYTLMIZCT-HHMYAMTESA-N

Canonical SMILES

CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O

Isomeric SMILES

C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C\C(=O)O1)O)O

Further Information

Solubility ( literature )

Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate

Compound Classification

Macrocyclic lactone antibiotic.
Antifungal
Antiviral
Protein Synthesis Inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus.
Inhibitor of intracellular protein transport and protein secretionA macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Warnings