Diacetoxyscirpenol (DAS)

Molecular Formula

C19H26O7

M.W.

366.41

CAS number

2270-40-8

Details

Source

Fusarium sp

Fermentek product Code

DAS-001

Specifications

Appearance

White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

160°C-165°C

Solubility test

Clear colorless solution at 10mg/ml Methanol ; Clear colorless solution at 10mg/ml dichloromethane

Chemical identification

Names and identifiers

Synonyms

Anguidine,
DAS
Diacetoxyscirpenol

RTECS YD0112000

EU number

218-873-3

Description

Diacetoxyscirpenol (DAS) also known as Anguidine, is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins.

DAS inhibits initiation of protein synthesis, causing the death of intensively replicating cells. By the virtue of this effect, DAS possesses teratogenic and anti proliferatory properties. Consequently, DAS attracts interest as a potential cancer- drug.

InChl Key

AUGQEEXBDZWUJY-ZLJUKNTDSA-N

Canonical SMILES

CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C

Isomeric SMILES

CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H]([C@H]([C@H]([C@]34CO4)O2)O)OC(=O)C)C)COC(=O)C

Further Information

Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification

trichothecene mycotoxin
Apoptosis inducer

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Semi-Synthetic

Composition

Ingredient type

Fermentek product

Special Info

Available since

2010