Diacetoxyscirpenol (DAS)

Molecular Formula:

C19H26O7

CAS number:

2270-40-8

EU number:

218-873-3

Fermentek product code:

DAS

Source:

Fusarium sp

Specifications

Appearance:

White powder

Purity by HPLC:

≥98% ; refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Melting point:

160°C-165°C

Solubility test:

Clear colorless solution at 10mg/ml Methanol ; Clear colorless solution at 10mg/ml dichloromethane

Chemical identification

Names and identifiers:

Synonyms

Anguidine
DAS
Diacetoxyscirpenol
12,13-epoxytrichothec-9-ene-3α,4β,15-triol 4,15-diacetate

HSDB 7244

RTECS YD0112000

Description:

Diacetoxyscirpenol (DAS) also known as Anguidine, is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins. DAS inhibits initiation of protein synthesis, causing the death of intensively replicating cells. By the virtue of this effect, DAS possesses teratogenic and anti proliferatory properties. Consequently, DAS attracts interest as a potential cancer- drug.

Molecular weight:

366.41

InChl Key:

AUGQEEXBDZWUJY-ZLJUKNTDSA-N

Canonical SMILES:

CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C

Isomeric SMILES:

CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H]([C@H]([C@H]([C@]34CO4)O2)O)OC(=O)C)C)COC(=O)C

Further Information

Solubility ( literature ):

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification:

trichothecene mycotoxin
Apoptosis inducer

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Expiration time:

Retest time:

Applications:

Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Semi-Synthetic

Composition

Ingredient type:

Fermentek product

Supply related information

Supply related comments:

Customs: Laboratory reagents-38220000

Shipped at ambient temperature

Transport safety: class 6.1 PG II

This compound is on Select Agents and Toxins list.

This compound is on Dual Use list.

Publications

*** This compound is on Select Agents and Toxins List *** of the US Department of Agriculture.
*** HHS and USDA Select Agents and Toxins. 7CFR Part 331, 9 CFR Part 121, and 42 CFR Part 73

Special Info

Available since:

2010

Other Fields

Title:

Deleted CAS Numbers

Value:

11011-10-2 ; 22135-66-6 ; 25662-95-7 ; 28776-47-8 ; 109547-11-7 ; 145427-91-4 ; 852223-87-1 ;