Leptomycin A
Molecular Formula
C32H46O6
M.W.
526.70
CAS number
87081-36-5
Details
Source
Streptomyces sp
Fermentek product Code
LPA-001
Brand/grade
For research
Specifications
Appearance
Lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Chemical identification
Names and identifiers
Synonyms:
- Antibiotic ATS 1287A
- Antibiotic PD 118607
- Jildamycin
Chemical names:
- Jildamycin
- Leptomycin A
IUPAC:
(2E,10E,12E,16Z,18E)-6-hydroxy-3,5,7,9,11,15,17-heptamethyl-19-(3-methyl-6-oxo-2,3-dihydropyran-2-yl)-8-oxononadeca-2,10,12,16,18-pentaenoic acid
RTECS#: RA5391000
EU number
N.A.
Description
Unsaturated Fatty Acid polyketide with cytotoxic activity. Leptomycin A is an inhibitor of CRM1 (exportin 1) that blocks CRM1 interaction with nuclear export signals, preventing the nuclear export of a broad range of proteins.
InChl Key
QECBVZBMGUAZDL-SJMSETAHSA-N
Canonical SMILES
CC1C=CC(=O)OC1C=CC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C
Isomeric SMILES
CC1C=CC(=O)OC1/C=C/C(=C\C(C)C/C=C/C(=C/C(C)C(=O)C(C)C(C(C)C/C(=C/C(=O)O)/C)O)/C)/C
Further Information
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Supply related information
Shipped at ambient temperature
Shipped in PP / PE bottle.
Special Info
Available since
Other Fields
Fermentek Product Category
Signal to sort
L
