- Ammonium Ionophore.
Nonactin from Streptomyces griseus is a mixture of the three homolog macrotetrolide antibiotics: Nonactin, Monactin and Dinactin.
soluble in Methanol, Dichloromethane, Ethyl Acetate, DMSO.
Insoluble in water
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells.
Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria.
Nonactin is used in urea and ammonium specific electrodes.