Variety on immunomodulators, which specifically supresses the immunological response.

Administration of immunosuppressive medications or immunosuppressants is the main method of deliberately induced immunosuppression, in optimal circumstances, immunosuppressive drugs are targeted only at any hyperactive component of the immune system.

People with previous cancer who require immunosuppression are not more likely to have a recurrence, throughout its history, radiation therapy has been used to decrease the strength of the immune system. Dr. Joseph Murray of Brigham and Women's Hospital, was given the Nobel Prize in Physiology or Medicine in 1990 for work on immunosuppression.

Immunosuppressive drugs have the potential to cause immunodeficiency, which can cause increased susceptibility to opportunistic infections and decreased cancer immunosurveillance.

Immunosuppressants may be prescribed when a normal immune response is undesirable, such as in autoimmune diseases.

Steroids were the first immunosuppressant identified, but its side-effects limited its use, the more specific azathioprine was identified in 1960, but it was the discovery of ciclosporin in 1980 (together with azathioprine) that allowed significant expansion of transplantation to less well-matched donor-recipient pairs as well as broad application to lung transplantation, pancreas transplantation, and heart transplantation.

After an organ transplantation, the body will nearly always reject the new organ(s) due to differences in human leukocyte antigen between the donor and recipient. As a result, the immune system detects the new tissue as "foreign", and attempts to remove it by attacking it with white blood cells, resulting in the death of the donated tissue, immunosuppressants are given as an attempt to prevent this rejection; the side-effect is that the body becomes more vulnerable to infections and malignancy.

Prodigiosin hydrochloride

Prodigiosin hydrochloride
Molecular Formula
C20H25N3O·HCl
M.W.
359.89
CAS number
56144-17-3
MSDS
Source
Serratia marcescens
Fermentek product Code
PRD-001
Brand/grade
For research
Appearance
Dark Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml of Methanol, Clear red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Disambiguation:    Do not confuse with Prodigiozan, another antibiotic from the same source.

Chemical names:   2,​2'-​Bi-​1H-​pyrrole, 4-​methoxy-​5-​[(5-​methyl-​4-​pentyl-​2H-​pyrrol-​2-​ylidene)​methyl]​-​, hydrochloride (1:1)

IUPAC:                    (2Z)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-(1H-pyrrol-2-yl)pyrrole;hydrochloride

RTECS                     DW2977000   refers to prodigiosin free base 

EU number
Not listed
Chemical name
4-Methoxy-5-[(E)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
Merck index
14: 7767
Description

Prodigiosin is a antibiotic from Serratia marcescens and some other bacterial species. It displays a wide range of biological activities, making it a promissing candidate drug. Among these are antimalarial, antifungal, anti-cancer, immunosuppressant, and antibiotic properties.

InChl Key
UQRGJSTXVCWXNU-JHMJKTBASA-N
Canonical SMILES
CCCCCC1=C(NC(=C1)C=C2C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Isomeric SMILES
CCCCCC1=C(NC(=C1)/C=C/2\C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Solubility ( literature )

(Data from literature including scientific publications and books, patents and other vendors)

Prodigiosin is soluble in acetonitrile, ethanol, methanol, chloroform, and DMSO. It is insoluble in water.

Compound Classification

UNSPSC

  • 51000000  Drugs and Pharmaceutical Products
  • 51200000  Immunomodulating drugs
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

For research only!

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
depreciated CAS
Value
30814-03-0; 47371-61-9;
Title
Transport
Value
NDG
Fermentek Product Category
Antibiotics
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Mitotic
Anti Fungal
Anti Protozoal
Anti Parasitic
Anti Bacterial
Anti Tumor agents
Immunosupressors
Signal to sort
P

Quote for

Price
$1.00

Emodin

Emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
518-82-1
MSDS
Fermentek product Code
EMO-001
Brand/grade
For research
Appearance
Orange Powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-265°C
Solubility test
Clear yellow to red solution at 50mg/ml of DMSO;
Clear yellow to red solution at 10mg/ml of Ethanol (may need a little warming)
Names and identifiers

Synonyms

  • Archin
  • Emodol
  • Frangula emodin
  • Frangulic acid
  • Rheum emodin

 Chemical names    Emodin

RTECS                    CB7920600

EU number
208-258-8
Chemical name
Emodin
Description

 Emodin is an anthraquinone class compound. It is sourced from a plant Rheum palmatum. It exhibits antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. 

InChl Key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O
Solubility ( literature )

Water Solubility <0.1 g/100 mL at 19ºC ; Practically insoluble in water; soluble in alcohol, aqueous alkali hydroxide solutions (cherry red color), (src: Merck index)

Compound Classification

Emodin has been investigated for the treatment of Polycystic Kidney.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
phys appearance
Value
Emodin appears as orange needles or powder.
Title
CN EU 29146980
Value
Ketones and quinones; Quinones; Other; Other
Title
Usage:
Value
Only for research in the field of cancer
Title
Usage:
Value
Emodin has been investigated for the treatment of Polycystic Kidney
Fermentek Product Category
Plant-derived
Antibiotics
Angiogenesis related
Apoptosis related
Protein kinase related
Cardiovascular agents
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Immunosupressors
Research field: Inflamation
Signal to sort
E

Quote for

Price
$10,000.00
Emodin.gif
Emodin.gif

Triptolide

Triptolide
Molecular Formula
C20H24O6
M.W.
360.40
CAS number
38748-32-2
Source
Tripterygium wilfordii
Fermentek product Code
TRP-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
223°C-230°C
Solubility test
Clear colorless solution at 10mg/ml of Acetonitrile
Names and identifiers

Synonyms:

  • NSC 163062
  • PG490

Chemical names:
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

IUPAC: 
(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-(propan-2-yl)-3,6,10,16-tetraoxaheptacyclo[11.7.0.0^{2,4}.0^{2,9}.0^{5,7}.0^{9,11}.0^{14,18}]icos-14(18)-en-17-one

RTECS#: YK7751000

EU number
683-214-2
Chemical name
Triptolide
Description

Triptolide is a diterpenoid epoxide which is produced by Tripterygium wilfordii, a vine used in traditional Chinese medicine. Triptolide has pharmacological activities including anti-inflammatory, immune-supressing, antiproliferative anti-angiogenetic, and proapoptotic activity. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer.

InChl Key
DFBIRQPKNDILPW-CIVMWXNOSA-N
Canonical SMILES
CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
Isomeric SMILES
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Solubility ( literature )

Reportedly: Insoluble in water. Insoluble in Ethanol. Soluble up to 0.2Molar ( 72 mg/ml) of DMSO

Compound Classification

Chemical classification:  Terpenoid

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport safety
Value
NDG
Title
solubility
Value
mrck DMSO (20 mg/ml); others: 0.2 molar in DMSO
Title
source comment
Value
From plant
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Apoptosis related
Cancer Related Compounds
Anti Tumor agents
Immunosupressors
Signal to sort
T

Quote for

Price
$100.00
Triptolide.gif
Triptolide.gif

Hypericin

Hypericin
Molecular Formula
C30H16O8
M.W.
504.44
CAS number
548-04-9
Source
Hypericium perforatum (plant extract)
Fermentek product Code
HYP-001
Brand/grade
For research
Appearance
Blue – black powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml DMSO
Names and identifiers
  • Cyclo-Werrol
EU number
208-941-0
Description

Natural antidepressant. Anti-retroviral agent. A protein kinaze-C inhibitor.

InChl Key
BTXNYTINYBABQR-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
Solubility ( literature )

Soluble in alkaline aqueous solutions. Soluble in organic bases such as pyridine (red fluorescent solutions) but not in other organic solvents

Compound Classification
  • Perylene analog.
  • Anthraquinone derivative
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Antidepressant. Apoptosis inducer. PKC inhibitor. Antiviral

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS numbers
Value
345224-62-6; 693273-27-7;935869-37-7
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Research field: Cancer
Protein kinase related
Anti Viral
Cancer Related Compounds
Immunosupressors
Immunomodulators
Signal to sort
H

Quote for

Price
$1.00
Hypericin.gif
Hypericin.gif

FK-506

FK506 (Tacrolimus)
Molecular Formula
C44H69NO12
M.W.
804.02
CAS number
104987-11-3
Source
Streptomyces tsukubaensis
Fermentek product Code
FK5-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
125°C-132°C
Solubility test
Clear colorless solution at 10 mg/ml Ethyl Acetate or DMSO
Names and identifiers

Synonyms: FK506, Tacrolimus,

RTECS:       KD4200000

EU number
658-056-2
Chemical name
FK506
Description

FK506 is 23-membered macrolide lactone discovered in 1984, by Kino T, Hatanaka H and Hashimoto M. [reference 2] FK506 exhibits potent inhibitory effect on T- lymphocyte activation. It binds to immunophilins FK506 binding proteins (FKBP-12) and a complex of FKBP-12, calcium, calmodulin and calcineurin is formed, inhibiting phosphatase activity of calcineurin. This prevents dephosphorylation and translocation of nuclear factor of activated T – cells (NF-AT) and inhibits transcription of early T-cell activation gene, Interleukin-2, Tumour Necrosis Factor (TNF-a) and proto-oncogenes; suppressing expression of IL-2 and IL-7 receptor. This results in inhibition of T-lymphocyte activation. FK506 also inhibits the mixed lymphocyte reaction, generation of cytotoxic T-cells and T-cell dependent B-cell activation.

InChl Key
QJJXYPPXXYFBGM-LFZNUXCKSA-N
Canonical SMILES
CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
Isomeric SMILES
C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
Solubility ( literature )

FK506 is soluble in Methanol, Ethanol, Acetone, Ethyl Acetate, Diethyl ether, Chloroform, Dicloromethane. FK506 is sparingly soluble in Hexane, Petroleum ether. FK506 is insoluble in water

Compound Classification

Chemical classification:

Macrolide

Bioactivity classification

Immunosuppressant

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Retest time
3 Years
Applications

FK506 (Tacrolimus) is used as an immunosuppressant at organ transplantations. For experimental uses of FK506 (Tacrolimus) read also United States Patent Application 20090098200

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
toxicity by RTECS
Value
>200mg/kg oral mouse
Fermentek Product Category
Antibiotics
Immunosupressors
Immunomodulators
Signal to sort
F

Quote for

Price
$1.00
FK_506.gif
FK_506.gif

Deoxynivalenol

Deoxynivalenol (DON)
Molecular Formula
C15H20O6
M.W.
296.30
CAS number
51481-10-8
MSDS
Source
Semisynthetic
Fermentek product Code
DON-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
150°C-155°C
Solubility test
Clear colorless solution at 10mg/ml Methanol or Ethyl acetate

Names and identifiers
  • Rd toxin
  • Vomitoxin
  • Deoxynivalenol
  • 4-Deoxynivalenol
  • Dehydronivalenol
  • 4-Desoxynivalenol

RTECS YD0167000

EU number
610-668-0
Description

Deoxynivalenol (DON , Vomitoxin) is a type B trichothecene. It occurs in grains such as wheat, barley, oats, rye, and maize, rice, sorghum. Deoxynivalenol (DON ) is produced by numerous strains of Fusarium and some other fungi. Deoxynivalenol (DON ) poisonings occur both in humans and farm animals. Deoxynivalenol (DON ) is highly toxic, producing a wide range of immunological disturbances and is particularly noted for inducing feed refusal and emesis in pigs, hence the alternative name vomitoxin Deoxynivalenol (DON ) usually co-occurs with other Fusarium toxins, such as Zearalenone, Nivalenol and its derivates, as well as the group of fumonisins.

InChl Key
LINOMUASTDIRTM-QGRHZQQGSA-N
Canonical SMILES
CC1=CC2C(C(C1=O)O)(C3(CC(C(C34CO4)O2)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3(C[C@H]([C@H]([C@@]34CO4)O2)O)C)CO
Solubility ( literature )

Deoxynivalenol (DON ) is soluble in common polar organic solvents as acetonitrile, methanol and ethyl acetate, slightly soluble in water.

Compound Classification

trichothecene type B mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

The main toxic effect of Deoxynivalenol (DON ) is inhibition of protein synthesis via binding to the ribosome.In agricultural R&D, DON is widely used to select crops strains with increased resistance against Fusarium.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
50722-37-7 ; 115825-61-1 ; 1394244-12-2
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Trichocothecenes
Enzyme-inhibitors
Protein synthesis inhibitors
DNA replication inhibitors
Immunosupressors
Immunomodulators
Signal to sort
D

Quote for

Price
$1.00
Deoxynivalenol.gif
Deoxynivalenol.gif

Ascomycin

Ascomycin
Molecular Formula
C43H69NO12
M.W.
792.01
CAS number
104987-12-4
Source
Streptomyces hygroscopicus subsp. ascomyceticus
Fermentek product Code
ASC-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
159°C-164°C
Solubility test
Ascomycin gives clear colorless solution at 10mg/ml Ethyl Acetate or 10mg/ml DMSO
Names and identifiers

 Synonyms

  • Immunomycin
  • FK520

RTECS KD4185000

EU number
435-850-5
Description

Ascomycin, also known as FK520, is a potent immunosuppressant.

Ascomycin inhibits allogenic T-lymphocyte proliferation.

InChl Key
ZDQSOHOQTUFQEM-PKUCKEGBSA-N
Canonical SMILES
CCC1C=C(CC(CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC1=O)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC)C)C
Isomeric SMILES
CC[C@@H]1/C=C(\C[C@@H](C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC)C)/C
Solubility ( literature )

DMSO, Methanol, Ethanol, EtOAc (Ethyl Acetate)

Compound Classification
  • macrolide
  • immunosuppressant
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Ascomycin is used in the research of immunological phenomena, such as organs transplantation, allergy, and the like. To our best knowledge, Ascomycin is neither used nor approved for clinical use of any kind, although related or similar compounds might serve as drug components. Specifically, Ascomycin from Fermentek is has no pharmacological use whatsoever. It is only offered for research, to universities and other research embodiments, to be used by qualified scientists only.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Cancelled CAS numbers
Value
11011-38-4 ; 126340-36-1 ; 133876-12-7 ; 136457-58-4 ; 137767-75-0 ; 148400-02-6 ; 159430-76-9
Fermentek Product Category
Antibiotics
Immunosupressors
Immunomodulators
Research field: Immunology
Signal to sort
A

Quote for

Price
$1.00
Ascomycin.gif
Ascomycin.gif
Subscribe to Immunosupressors