17-DMAG-hydrochloride
Molecular Formula
C32H48N4O8.HCl
M.W.
653.20
CAS number
467214-21-7
MSDS
Details
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-002
Brand/grade
For research
Specifications
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
215°C-230°C
Solubility test
Clear purple solution at 1mg / ml H2O
Chemical identification
Names and identifiers
Synonyms:
- 17-DMAG HCl
- Alvespimycin HCl
- 17-Dimethylaminoethylamino-17-demethoxygeldanamycin Hydrochloride
IUPAC Name:
[(4E,6E,9S,10E,12S,13R,16R)-19-[2-(dimethylamino)ethylamino]-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate;hydrochloride
RTECS: LX8922000
Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin Hydrochloride
Description
17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.
17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.
InChl Key
DFSYBWLNYPEFJK-LYGDSXLOSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC.Cl
Isomeric SMILES
C[C@H]1CC([C@@H]([C@H](/C=C(/[C@@H](C(/C=C/C=C(/C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)\C)OC)OC(=O)N)\C)C)O)OC.Cl
Further Information
Solubility ( literature )
DMSO, Methanol, Ethanol
Compound Classification
- Benzoquinone ansamycin class antibiotic
- Geldanamycin derivate
- HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications
HSP-90 inhibitor; potential anti-cancer drug
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Composition
Ingredient type
Fermentek product
Supply related information
Shipped at ambient temperature
Shipped in PP / PE bottle.
Special Info
Available since
Other Fields
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF/SF-mediated Met tyrosine kinase
Title
Target
Value
ATP-binding site of amino-terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Signal to sort
D
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