IUPAC Name : [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate I
Geldanamycin is a benzoquinone ansamycin antibiotic, which binds to Hsp90 (Heat Shock Protein 90) and alters its function. Geldanamycin is a natural product from which several valuable derivates were synthesized. All derivates share its HSP90 inhibition, and vary in overall toxicity and water solubility.
Geldanamycin is soluble in DMSO, Dichloromethane. Geldanamycin is insoluble in water.
Benzoquinone ansamycin antibiotic ;
HSP90 inhibitor ;
Tyrosine Kinase Inhibitor ;
Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors.