Salinomycin

Molecular Formula:

C42H70O11

CAS number:

53003-10-4

EU number:

258-290-1

Fermentek product code:

Source:

Streptomyces sp.

Brand/grade:

For research

Specifications

Appearance:

White to slight yellow lyophilizate

Purity by HPLC:

≥98% ; refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Solubility test:

Clear colorless solution at 10mg/ml of DMSO

Chemical identification

Names and identifiers:

Synonyms:

Procoxacin
Coxistac
Antibiotic 61477

Chemical names:

IUPAC:

(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

RTECS# VO8620000

Chemical name:

Salinomycin

Description:

A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.

Molecular weight:

751.00

InChl Key:

KQXDHUJYNAXLNZ-XQSDOZFQSA-N

Canonical SMILES:

CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O

Isomeric SMILES:

CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O

Further Information

Solubility ( literature ):

Reported to be soluble in methanol (10 mg/mL)

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Expiration time:

Retest time:

Applications:

While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Publications

Gupta, P.B., Onder, T.T., Jiang, G.
Identification of selective inhibitors of cancer stem cells by high-throughput screening.
Cell 138, 645-59 (2009).

Ewen Callaway
Drug shows cancer stem cells not invulnerable

New Scientist /health 13 August 2009

Cord Naujokat; Dominik Fuchs; Gerhard Opelz
Salinomycin in cancer: A new mission for an old agent
https://doi.org/10.3892/mmr_00000296 Pages: 555-559

Special Info

Available since:

2020

Other Fields

Title:

Transport information

Value:

Pg III

Title:

reach

Value:

On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013.

Title:

EU Customs Code CN

Value:

29419000

Title:

Harmonized Tariff Code

Value:

294190

Title:

general comment

Value:

there is Na Salinomycin w cas 55721-31-8

Title:

toxicity by RTECS

Value:

LD50 oral mouse 50 mg/kg

Title:

Deleted CAS Registry Numbers

Value:

37362-39-3 ; 50863-72-4

Quote for

Salinomycin

Specifications

Chemical identification

Further Information

Composition

Publications

Special Info

Other Fields

Related products

Nigericin-sodium-salt-28643-80-3.png

Quote for