Salinomycin
Molecular Formula
C42H70O11
M.W.
751.00
CAS number
53003-10-4
MSDS
Source
Streptomyces sp.
Fermentek product Code
SAL-001
Brand/grade
For research
Appearance
White to slightly yellow lyophilizated powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Procoxacin
  • Coxistac
  • Antibiotic 61477

Chemical names:

IUPAC:

(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

RTECS# VO8620000

 
EU number
258-290-1
Chemical name
Salinomycin
Description

A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example  methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. 

As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.

 

 

InChl Key
KQXDHUJYNAXLNZ-XQSDOZFQSA-N
Canonical SMILES
CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O
Isomeric SMILES
CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O
Solubility ( literature )

Reported to be soluble in methanol (10 mg/mL)

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
reach
Value
On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013.
Title
EU Customs Code CN
Value
29419000
Title
Harmonized Tariff Code
Value
294190
Title
general comment
Value
there is Na Salinomycin w cas 55721-31-8
Title
toxicity by RTECS
Value
LD50 oral mouse 50 mg/kg
Title
Deleted CAS Registry Numbers
Value
37362-39-3 ; 50863-72-4
Signal to sort
S