Specifications
Chemical identification
Synonyms:
- Procoxacin
- Coxistac
- Antibiotic 61477
Chemical names:
IUPAC:
(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid
RTECS# VO8620000
A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.
Further Information
Reported to be soluble in methanol (10 mg/mL)
While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.
Composition
Publications
- Gupta, P.B., Onder, T.T., Jiang, G.
- Identification of selective inhibitors of cancer stem cells by high-throughput screening.
- Cell 138, 645-59 (2009).
- Ewen Callaway
- Drug shows cancer stem cells not invulnerable
- New Scientist /health 13 August 2009
- Cord Naujokat; Dominik Fuchs; Gerhard Opelz
- Salinomycin in cancer: A new mission for an old agent
- https://doi.org/10.3892/mmr_00000296 Pages: 555-559
