Myriocin
Molecular Formula
C21H39NO6
M.W.
401.54
CAS number
35891-70-4
MSDS
Source
Mycelia sterilia (fungus)
Fermentek product Code
MYR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
164°C-184°C
Solubility test
Clear colorless solution at 2mg/ml of Methanol (slight heating),
Clear colorless solution at 5mg/ml of DMSO (slight heating)
Names and identifiers
  • Myriocin
  • Thermozymocidin,
  • ISP-I
  • (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
EU number
636-862-5
Description

Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer.

InChl Key
ZZIKIHCNFWXKDY-GNTQXERDSA-N
Canonical SMILES
CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O
Isomeric SMILES
CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
Solubility ( literature )

Myriocin is slightly soluble in DMSO, alcohols.Myriocin is insoluble in water and in most organic solvents.

Compound Classification
  • amino-acid antibiotic
  • immunosupressor
  • serine palmitoyltransferase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Myriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids. Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: class 6.1 PG III
Available since
Title
Toxicity oral mouse LD50
Value
300 miligram/kg
Signal to sort
M