Enzyme inhibitors:

These compounds block the action of miscelaneous enzymes. We intentionally did not include proteine kinaze inhibitors into this category, preferring creation of a separate category for these.

Citreoviridin

Citreoviridin
Molecular Formula
C23H30O6
M.W.
402.48
CAS number
25425-12-1
Source
Penicillium sp.
Fermentek product Code
CIR-001
Brand/grade
For research
Appearance
Yellow to Orange-yellow powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
107°C-112°C
Solubility test
Clear yellow solution at 10mg/ml of DMSO, Methanol or Dichloromethane
Names and identifiers

Synonyms

  • Citreoviridin A
  • 4-Methoxy-5-methyl-6-(7-methyl-8-(tetrahydro-3,4-dihydroxy-2,4,5-trimethyl-2-furyl)-1,3,5,7-octatetraenyl)-2H-pyran-2-one
  • IUPAC Name: 6-[(1E,3E,5E,7E)-8-[(2S,3R,4R,5R)-3,4-Dihydroxy-2,4,5-trimethyloxolan-2-yl]-7-methylocta-1,3,5,7-tetraenyl]-4-methoxy-5-methylpyran-2-one

 RTECS: UQ1235000

EU number
636-737-5
Chemical name
Citreoviridin
Description

Citreoviridin is a neurotoxic mycotoxin from Penicillium citeoviride, Penicillium toxicarium, Penicillium ochrosalmoneum, Penicillium ochrosalmoneum, Aspergillus terreus, and several other related fungi. Citreoviridin is believed to be the cause of the Acute Cardiac Beri-Beri disease. Naturally, It is formed on rice improperly stored.

InChl Key
JLSVDPQAIKFBTO-OMCRQDLASA-N
Canonical SMILES
CC1C(C(C(O1)(C)C=C(C)C=CC=CC=CC2=C(C(=CC(=O)O2)OC)C)O)(C)O
Isomeric SMILES
C[C@@H]1[C@]([C@H]([C@](O1)(C)/C=C(\C)/C=C/C=C/C=C/C2=C(C(=CC(=O)O2)OC)C)O)(C)O
Solubility ( literature )

Citreoviridin is soluble in benzene, ethanol, chloroform, ether, dichloromethane. Citreoviridin is hardly soluble in water (enough to give it yellow color) and hexane

Compound Classification

Aurovertin class mycotoxin

Comment: Aurovertins are very toxic and complex pyrone derivatives of fungal origin . They bind to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation. They are used as biochemical tools.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Applications

As other Aurovertin group members, Citreoviridin binds to and inhibit mitochondrial ATPase, thereby uncoupling oxidative phosphorylation.

Citreoviridin, a mycotoxin that has been shown to inhibit the mitochondrial ATP synthetase system. It inhibits soluble ATPase, ADP-stimulated respiration in isolated rat liver mitochondria, and ATP-driven reduction of NAD+ by succinate (KD = 2 µM). Citreoviridin has been used to target ectopic ATPase activity in cancer cells in order to modulate the metabolic activity associated with tumorigenesis.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Antibiotics
Enzyme-inhibitors
Signal to sort
C

Quote for

Price
$1.00
Citreoviridin.gif
Citreoviridin.gif

Chelerythrine chloride

Chelerythrine chloride
Molecular Formula
C21H18NO4∙Cl
M.W.
383.82
CAS number
3895-92-9
Source
Chelidonium majus
Fermentek product Code
CHE-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
202°C-208°C
Solubility test
Clear yellowish solution at 5mg/ml Methanol
Names and identifiers

EINECS 223-444-9

1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride

Chelerythrine hydrochloride

EU number
223-444-9
Description

Chelerythrine: A benzophenanthridine alkaloid. A potent, selective, and cell-permeable PKC inhibitor.Chelerythrine is very closely related to sanguinarine. Unlike sanguinarine which is found in the green biomass of Chelidonium, Chelerythrine mainly occurs in its roots.

InChl Key
WEEFNMFMNMASJY-UHFFFAOYSA-M
Canonical SMILES
C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
Solubility ( literature )

Methanol, Water, DMSO

Compound Classification

Benzophenanthridine alkaloid

PKC inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Oral Toxicity Mouse
Value
No data.
Title
Transport safety information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Signal to sort
C

Quote for

Price
$1.00
Chelerythrine_Chloride.gif
Chelerythrine_Chloride.gif

Cerulenin

Cerulenin
Molecular Formula
C12H17NO3
M.W.
223.27
CAS number
17397-89-6
MSDS
Source
Cephalosporium caerulens
Fermentek product Code
CER-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml of Dichloromethane
Names and identifiers

Synonyms

  • Cerulenin
  • Helicocerin

IUPAC Name: (2R,3S)-3-[(4E,7E)-Nona-4,7-dienoyl]oxirane-2-carboxamide

Systematic name: (2R,3S)-3-[(4E,7E)-4,7-Nonadienoyl]-2-oxiranecarboxamide

RTECS: JR1670000

EU number
241-424-8
Chemical name
7,10-Dodecadienamide, 2,3-epoxy-4-oxo-
Description

Cerulenin: an antifungal antibiotic, fatty acids and sterols biosynthesis inhibitor.

InChl Key
GVEZIHKRYBHEFX-NQQPLRFYSA-N
Canonical SMILES
CC=CCC=CCCC(=O)C1C(O1)C(=O)N
Isomeric SMILES
C/C=C/C/C=C/CCC(=O)[C@@H]1[C@@H](O1)C(=O)N
Solubility ( literature )

Cerulenin is soluble in DMSO, Methanol, Ethanol, Dichloromethane, Acetone, Benzene and most common solvents. Concentrations up to 20 mg/ml can be achieved. Slightly soluble in H2O. Concentrations up to 0.2 mg/ml are achievable.Not soluble in Petrol Ether.Attention: Cerulenin is unstable in aqueous solutions, and very unstable in basic solutions

Compound Classification

 

  • Fatty acid antibiotic.
  • Apoptosis inducer
  • Antifungal antibiotic
  • Mycobacteria inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

Cerulenin was originally proposed as antifungal antibiotic. Cerulenin is used as a biochemical tool. Cerulenin has been shown to cause dramatic weight loss in animals. Cerulenin blocks synthesis of fatty acids and sterols by binding to the enzyme fatty-acid-synthase. In some tumor lines, this triggers apoptosis., an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FAS pathway.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Oral Toxicity Mouse
Value
547 mg/kg ; category 4
Title
Deleted CAS Numbers
Value
11052-24-7; 23557-85-9
Title
Transport information
Value
Not regulated/not hazardous
Title
stability comments
Value
in higher pH, not stable. use some acidifier
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Anti Bacterial
Signal to sort
C

Quote for

Price
$1.00
Cerulenin.gif
Cerulenin.gif

Borrelidin

Borrelidin
Molecular Formula
C28H43NO6
M.W.
489.64
CAS number
7184-60-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
BOR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
106°C-114°C
Solubility test
Clear colorless solution at 10 mg/ml of Methanol or DMSO or Chloroform
Names and identifiers
  • Treponemycin
  • Cyclopentanecarboxylic acid
  • 2-[(4E,6E)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
  • RTECS ED8750000
EU number
811-923-0
Description

Borrelidin is a macrolide-polyketide antibiotic displaying anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties.

InChl Key
OJCKRNPLOZHAOU-UGKRXNSESA-N
Canonical SMILES
CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
Isomeric SMILES
C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C
Solubility ( literature )

Borrelidin is soluble in DMF, DMSO, Ethanol, Ethyl acetate, Methanol

Compound Classification
  • Cyclin-dependent kinase (CDK) inhibitor ;
  • Antiviral agent
  • Anti- Angiogenetic agent
  • Apoptosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Applications

Borrelidin, a potent antifungal agent

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
1403-11-8; 97328-74-0
Title
Transport information
Value
Not hazardous for transport
Title
Inhibitor of:
Value
threonyl aminoacyl-tRNA synthetase; cyclin-dependent kinase (CDK).
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein synthesis inhibitors
Anti Protozoal
Anti Bacterial
Anti Viral
Cancer Related Compounds
Signal to sort
B

Quote for

Price
$1.00
Borrelidin.gif
Borrelidin.gif

Bafilomycin A1

Bafilomycin A1
Molecular Formula
C35H58O9
M.W.
622.83
CAS number
88899-55-2
MSDS
Source
Streptomyces griseus
Fermentek product Code
BFA-001
Brand/grade
For research
Appearance
Yellow to white powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
150°C-166°C
Solubility test
Clear colorless to yellow solution at 5mg/ml Methanol or DMSO
Names and identifiers

IUPAC Name: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one

EU number
621-324-4
Description

Bafilomycin A1 is toxic macrolide antibiotic acts as a specific inhibitor of vacuolar-type H+-ATPase. It acts as autophagy Inhibitor

InChl Key
XDHNQDDQEHDUTM-JQWOJBOSSA-N
Canonical SMILES
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)O)O)O)OC)C
Isomeric SMILES
C[C@H]1C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)O)O)O)OC)/C
Solubility ( literature )

Soluble in 100% ethanol, methanol or DMSO.

Compound Classification

Macrolide antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
1.5 Years
Applications

Bafilomycin A1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms. Bafilomycin A1 is useful in distinguishing among different types of ATPases. Bafilomycin A1 can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. Antibacterial, Antifungal, Antineoplastic, Immunosuppressive Bafilomycin A1 has been shown to decrease multi-drug resistance.

Bafilomycin A1, inhibits vacuolar-​ATPase.
It is a potassium ionophore that impairs mitochondrial functions.
It activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria.
Bafilomycin A1 has been commonly used as a method of inhibition of infection by viruses known or suspected to follow the path of receptor-​mediated endocytosis and low-​pH-​mediated membrane fusion
Vacuolar ATPase inhibitors overcome Bcl-​xL-​mediated chemoresistance through restoration of a caspase-​independent apoptotic pathway.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
storage
Value
TRC,Merck: under inert gas+hygros+light
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Anti Protozoal
Immunomodulators
Research area: Multi-drug resistance
Ionophores
Signal to sort
B

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Price
$1.00
Bafilomycin_A1.gif
Bafilomycin_A1.gif

Apicidin

Apicidin
Molecular Formula
C34H49N5O6
M.W.
623.80
CAS number
183506-66-3
Source
Fusarium sp.
Fermentek product Code
API-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
187°C-193°C
Solubility test
Clear colorless solution at 1 mg /ml Ethanol or DMSO
Names and identifiers

Synonyms:

  • apicidin C

IUPAC name:

  • (3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone

RTECS XJ6094046 

EU number
635-755-0
Description

Apicidin is a mycotoxin which may occur naturally, as a result of Fusarium fungi growing on improperly stored foods.

Apicidin is a potent cell permeable inhibitor of histone deacetylase.

 

InChl Key
JWOGUUIOCYMBPV-GMFLJSBRSA-N
Canonical SMILES
CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Solubility ( literature )

Ethanol, DMSO, Dichloromethane. Slightly soluble in water, methanol.

Compound Classification
  • Cyclic peptide antibiotic
  • Mycotoxin
  • Antiprotozoal
  • HDAC inhibitor
  • Angiogenesis inhibitor
Retest time
3 Years
Applications

Cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. An histone deacetylase inhibitor, Anti-angiogenic; Apoptosis inductor.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
research fields
Value
Systemic lupus erythematosus; Autoimmune diseases; Rheumatoid arthritis; Histone deacetylation;
Title
Safety comments
Value
RTECS only specifies mutagenity. Whoever says it is toxic, has no data to support
Fermentek Product Category
Antibiotics
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Protozoal
Research field: Signal Transduction
Ionophores
Others
Signal to sort
A

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Price
$1.00
Apicidin.gif
Apicidin.gif

Alternariol monomethyl ether

Alternariol monomethyl ether
Molecular Formula
C15H12O5
M.W.
272.25
CAS number
23452-05-3
MSDS
Source
Alternaria alternata
Fermentek product Code
AME-001
Brand/grade
For research
Appearance
Off-white to light pink powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless solution at 1mg/ml Acetone.
Clear colorless solution at 1mg/ml Methanol (slight heating).
Names and identifiers

Alternate names

  • AME
  • Djalonensone
  • Alternariol monomethyl ether
  • Alternariol methyl ether
  • Alternariol-9-methyl ether

RTECS : HP8755000

EU number
636-657-0
Description

Alternariol monomethyl ether (AME) is a natural mycotoxin originated in Alternaria alternata fungi . It inhibits  Cholinesterase, and posesses  antifungal and phytotoxic properties.

InChl Key
LCSDQFNUYFTXMT-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=CC2=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O
Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification

Pyrrolidinone mycotoxin

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Non hazardous for shipment.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CAS number validated
Value
26894-49-5; 641-38-3
Title
Deleted CAS Numbers
Value
31273-73-1; 916665-00-4; 11003-13-7
Fermentek Product Category
Food Safety
Mycotoxins
Alternaria toxins
Other mycotoxins
Antibiotics
Cytotoxic agents
Enzyme-inhibitors
Anti Bacterial
Anti Tumor agents
DNA replication inhibitors
Signal to sort
A

Quote for

Price
$1.00
Alternariol_monomethyl_ether.gif
Alternariol_monomethyl_ether.gif

Alamethicin

Alamethicin
Molecular Formula
C92H150N22O25
M.W.
1 964.30
CAS number
27061-78-5
MSDS
Source
Trichoderma viride
Fermentek product Code
ALA-001
Brand/grade
For research
Appearance
Off White to Beige powder
Purity by HPLC
4 peaks, complies to standard
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
252°C-272°C
Solubility test
Clear colorless solution at 10mg/ml DMSO or Methanol
Names and identifiers

 

Synonyms: Antibiotic U 22324

RTECS: AY1900000

EU number
608-040-6
Description

Alamethicin is a channel-forming ionophore. Chemically, it is a peptide of 20 amino acids. The product consists of a mixture of several isoforms, which may be slightly different in the amino-acids sequences, but possess the same activity.

 

InChl Key
LGHSQOCGTJHDIL-UTXLBGCNSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=CC=C2)CO)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C3CCCN3C(=O)C(C)(C)NC(=O)C
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CC=CC=C2)CO)NC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@@H]3CCCN3C(=O)C(C)(C)NC(=O)C
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  1. Peptide antibiotic
  2. Channel forming Ionophore
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Can mimic nerve action potential across artificial membranes

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS numbers
Value
11051-59-5; 55739-76-9
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Anti Bacterial
Research field: Signal Transduction
Ionophores
Signal to sort
A

Quote for

Price
$1.00
Alamethicin
Alamethicin

17-DMAG

17-DMAG
Molecular Formula
C32H48N4O8
M.W.
616.75
CAS number
467214-20-6
MSDS
Source
Semisynthetic Derivate of Geldanamycin
Fermentek product Code
17D-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
152°C-162°C
Solubility test
Clear purple solution at 25mg/ml DMSO; Clear purple solution at 10mg/ml Ethanol
Names and identifiers

Synonyms:

  • 17-DMAG
  • Alvespimycin
  • 17-Dimethylaminoethylamino-17-demethoxygeldanamycin

RTECS: LX8922000

 

Chemical name
17-dimethylaminoethylamino-17-demethoxy-geldanamycin
Description

17-DMAG, also known as Alvespimycin, is a semisynthetic derivate of Geldanamycin, of less hepatotoxicity, improved water solubility.

17-DMAG is an ansamycin antibiotic which binds to Hsp90 (Heat Shock Protein 90) and alters it function.

InChl Key
KUFRQPKVAWMTJO-LMZWQJSESA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCCN(C)C)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  • Benzoquinone ansamycin class antibiotic
  • Geldanamycin derivate
  • HSP90 inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

HSP-90 inhibitor; potential anti-cancer drug

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Harmonized Tariff Code
Value
294190
Title
Transport safety information
Value
Not hazardous for transport
Title
Target
Value
HGF​/SF-​mediated Met tyrosine kinase
Title
Target
Value
ATP-​binding site of amino-​terminal domain region of HSP 90
Title
CN code
Value
29419000
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
HSP90 inhibitors
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
D

Quote for

Price
$1.00
17-DMAG
17-DMAG
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