Apicidin
Molecular Formula
C34H49N5O6
M.W.
623.80
CAS number
183506-66-3
Details
Source
Fusarium sp.
Fermentek product Code
API-001
Brand/grade
For research
Specifications
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
187°C-193°C
Solubility test
Clear colorless solution at 1 mg /ml Ethanol or DMSO
Chemical identification
Names and identifiers
Synonyms:
- apicidin C
IUPAC name:
- (3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone
RTECS XJ6094046
EU number
635-755-0
Description
Apicidin is a mycotoxin which may occur naturally, as a result of Fusarium fungi growing on improperly stored foods.
Apicidin is a potent cell permeable inhibitor of histone deacetylase.
InChl Key
JWOGUUIOCYMBPV-GMFLJSBRSA-N
Canonical SMILES
CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Further Information
Solubility ( literature )
Ethanol, DMSO, Dichloromethane. Slightly soluble in water, methanol.
Compound Classification
- Cyclic peptide antibiotic
- Mycotoxin
- Antiprotozoal
- HDAC inhibitor
- Angiogenesis inhibitor
Retest time
3 Years
Applications
Cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. An histone deacetylase inhibitor, Anti-angiogenic; Apoptosis inductor.
Disclaimer
Refer to MSDS for further safety and handling instructions.
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Transport information
Value
Not hazardous for transport
Title
research fields
Value
Systemic lupus erythematosus; Autoimmune diseases; Rheumatoid arthritis; Histone deacetylation;
Title
Safety comments
Value
RTECS only specifies mutagenity. Whoever says it is toxic, has no data to support
Fermentek Product Category
Signal to sort
A
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