Apoptosis is defined as a process of deliberate cell suicide in a multicellular organism. It is one of the main types of programmed cell death (PCD), and involves an orchestrated series of biochemical events leading to a characteristic cell morphology and death.

The apoptotic process is executed in such a way as to safely dispose of dead cells and fragments.

Apoptosis is a crucial element of the ontogenesis of multicellular organisms. Any aberration in it may lead to neoplastic events, to cancer and to death of the entire organism. Therefore, the Fermentek "Apoptosis related products” are of use in biological and medical research. Some have been the basis for the development of novel drugs.

HC toxin

HC toxin
Molecular Formula
C21H32N4O6
M.W.
436.50
CAS number
83209-65-8
MSDS
Source
Helminthosporium carbonum
Fermentek product Code
HCT-001
Brand/grade
For research
Appearance
White lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Acetonitrile
Names and identifiers

Synonyms:

  • HC-Toxin

  • Helminthosporium Carbonum Toxin I

Chemical names:

IUPAC: (3S,6R,9S,14aR)-3,6-Dimethyl-9-{6-[(2S)-2-oxiranyl]-6-oxohexyl}decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetrone

RTECS#

EU number
804-302-0
Chemical name
Cyclo(2-amino-8-oxo-9,10-epoxydecanoic acid-prolyl-alanyl-alanine)
Description

Cyclic tetrapeptide of structure cyclo(D-Pro-L-Ala-D-Ala-L-Aeo), where Aeo stands for 2-amino-9,10-epoxi-8-oxodecanoic acid. HC toxin is a potent, cell-permeable  inhibitor of histone deacetylase (HDAC).

InChl Key
GNYCTMYOHGBSBI-KVUCBBCISA-N
Canonical SMILES
CC1C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C)CCCCCC(=O)C3CO3
Isomeric SMILES
C[C@@H]1C(=O)N[C@H](C(=O)N2CCC[C@@H]2C(=O)N[C@H](C(=O)N1)C)CCCCCC(=O)C3CO3
Compound Classification

Cyclic oligopeptide

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Registry Numbers
Value
82653-17-6; 89363-02-0; 110114-88-0
Fermentek Product Category
Enzyme-inhibitors
Apoptosis related
Anti Mitotic
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Others
Signal to sort
H

Quote for

Price
$100.00
HC_toxin.gif
HC_toxin.gif

Triptolide

Triptolide
Molecular Formula
C20H24O6
M.W.
360.40
CAS number
38748-32-2
Source
Tripterygium wilfordii
Fermentek product Code
TRP-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
223°C-230°C
Solubility test
Clear colorless solution at 10mg/ml of Acetonitrile
Names and identifiers

Synonyms:

  • NSC 163062
  • PG490

Chemical names:
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

IUPAC: 
(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-(propan-2-yl)-3,6,10,16-tetraoxaheptacyclo[11.7.0.0^{2,4}.0^{2,9}.0^{5,7}.0^{9,11}.0^{14,18}]icos-14(18)-en-17-one

RTECS#: YK7751000

EU number
683-214-2
Chemical name
Triptolide
Description

Triptolide is a diterpenoid epoxide which is produced by Tripterygium wilfordii, a vine used in traditional Chinese medicine. Triptolide has pharmacological activities including anti-inflammatory, immune-supressing, antiproliferative anti-angiogenetic, and proapoptotic activity. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer.

InChl Key
DFBIRQPKNDILPW-CIVMWXNOSA-N
Canonical SMILES
CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
Isomeric SMILES
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Solubility ( literature )

Reportedly: Insoluble in water. Insoluble in Ethanol. Soluble up to 0.2Molar ( 72 mg/ml) of DMSO

Compound Classification

Chemical classification:  Terpenoid

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport safety
Value
NDG
Title
solubility
Value
mrck DMSO (20 mg/ml); others: 0.2 molar in DMSO
Title
source comment
Value
From plant
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Apoptosis related
Cancer Related Compounds
Anti Tumor agents
Immunosupressors
Signal to sort
T

Quote for

Price
$100.00
Triptolide.gif
Triptolide.gif

Hydrolyzed Fumonisin B1 (Aminopentol)

Hydrolyzed Fumonisin B1 (Aminopentol)
Molecular Formula
C22H47NO5
M.W.
405.61
CAS number
145040-09-1
Source
Semisynthetic
Fermentek product Code
HFB-001
Brand/grade
For research
Appearance
Brown to yellow film
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear brown solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Aminopentol;
  • AP1

Chemical names:

IUPAC:

  • (2S,3S,5R,10R,12S,14S,15R,16R)-2-Amino-12,16-dimethyl-3,5,10,14,15-icosanepentol

 

RTECS#

  • not available.
EU number
Not registered.
Chemical name
Aminopentanol
Description

Hydrolyzed fumonisin B1 (aka aminopentol) is a mycotoxin which occurs naturaly together with fumonisin B1. It may be formed from fumonisin B1 by hydrolysis of the O-acyl bonds. 

InChl Key
UWWVLQOLROBFTD-GADKELDLSA-N
Canonical SMILES
CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)O)O
Isomeric SMILES
CCCC[C@@H](C)[C@H]([C@H](C[C@@H](C)C[C@@H](CCCC[C@H](C[C@@H]([C@H](C)N)O)O)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotGMO

Product natural

Ingredient type
Fermentek product
Transport safety: not regulated.
Available since
Title
Special tests done
Value
NMR: complies.
Title
HPLC
Value
lot 001: 99.6% by elsd
Title
ECHA inventory
Value
as at nov-8-2018, no EC number.
Title
Transport
Value
NDG
Title
safety general
Value
Not hazardous
Fermentek Product Category
Mycotoxins
Apoptosis related
Signal to sort
H

Quote for

Price
$500.00
Hydrolyzed_Fumonisin_B1.gif
Hydrolyzed_Fumonisin_B1.gif

Salinomycin

Salinomycin
Molecular Formula
C42H70O11
M.W.
751.00
CAS number
53003-10-4
MSDS
Source
Streptomyces sp.
Fermentek product Code
SAL-001
Brand/grade
For research
Appearance
White to slightly yellow lyophilizated powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Procoxacin
  • Coxistac
  • Antibiotic 61477

Chemical names:

IUPAC:

(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

RTECS# VO8620000

 
EU number
258-290-1
Chemical name
Salinomycin
Description

A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example  methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. 

As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.

 

 

InChl Key
KQXDHUJYNAXLNZ-XQSDOZFQSA-N
Canonical SMILES
CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O
Isomeric SMILES
CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O
Solubility ( literature )

Reported to be soluble in methanol (10 mg/mL)

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
reach
Value
On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013.
Title
EU Customs Code CN
Value
29419000
Title
Harmonized Tariff Code
Value
294190
Title
general comment
Value
there is Na Salinomycin w cas 55721-31-8
Title
toxicity by RTECS
Value
LD50 oral mouse 50 mg/kg
Title
Deleted CAS Registry Numbers
Value
37362-39-3 ; 50863-72-4
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Protozoal
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Ionophores
Signal to sort
S

Quote for

Price
$20.00
Salinomycin.gif
Salinomycin.gif

Tropodithietic acid (TDA)

Tropodithietic acid (TDA)
Molecular Formula
C8H4O3S2
M.W.
212.25
CAS number
750590-18-2
Source
Phaeobacter gallaeciensis
Fermentek product Code
TDA-001
Brand/grade
For research
Appearance
Orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
207°C-213°C
Solubility test
Clear yellow solution at 1 mg/ml of Dichloromethane.
Clear yellow solution at 0.5 mg/ml of Methanol
Names and identifiers

Synonyms:             TDA

Chemical names:   Tropodithietic acid

IUPAC:                    3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid

RTECS#                   Not available

 

EU number
806-061-7
Chemical name
Tropodithietic acid
Description

A sulphur containing antibiotic from marine bacteria, responsible for the probiotic proprties of some of these.  Tropodithietic acid It is active against Gram-positive and Gram-negative bacteria, some phytopathogens and mycoplasma. It also has anti-plasmodium activity.

InChl Key
BLFCMITWMARUSM-UHFFFAOYSA-N
Canonical SMILES
C1=CC(=O)C(=C2C(=C1)SS2)C(=O)O
Solubility ( literature )

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

Warning or harmful

  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    • Respiratory tract irritation
    • Narcotic effects
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
source
Value
Phaeobacter gallaeciensis
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Protozoal
Anti Bacterial
Signal to sort
T

Quote for

Price
$100.00
Tropodithietic_acid.gif
Tropodithietic_acid.gif

Concanamycin A (Folimycin)

Concanamycin A (Folimycin)
Molecular Formula
C46H75NO14
M.W.
866.09
CAS number
80890-47-7
Source
Streptomyces sp.
Fermentek product Code
CON-001
Brand/grade
For research
Appearance
White crystals
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Concamycin A
  • Folimycin
  • Concanamycin

Comment: Many other suppliers, as well as PUBCHEM, CHEMSPIDER and publications, consider Folimycin and Concanamycin A to be synonyms, while SCIFINDER considers these compounds to be different.

IUPAC: 

3-O-(4-O-Carbamoyl-2,6-dideoxy-β-D-arabino-hexopyranosyl)-2,4-dideoxy-1-C-{4-[(4E,6E,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen- 2-yl]-3-hydroxy-2-pentanyl}-4-methyl-5-[(1E)-1-propen-1-yl]-β-D-threo-pentopyranose

RTECS# CB9732000

 

EU number
620-709-4
Chemical name
Concanamycin A
Description

Macrolide type antibiotic, ATPase inhibitor, having antiproliferative, antifungal and antimalarial effects.

InChl Key
DJZCTUVALDDONK-HQMSUKCRSA-N
Canonical SMILES
CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
Isomeric SMILES
CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
Solubility ( literature )

Concanamycin A is reported to be soluble in chloroform, methanol, ethanol, acetone, ethyl acetate, and DMSO.

Concanamycin A is not soluble in water.

 

 

 

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Reportedly, OK to freeze; Frozen stock solutions in DMSO are stable 1 year
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
CN code
Value
--
Title
Depreciated CAS Registry Numbers
Value
66771-59-3
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Angiogenesis related
Apoptosis related
Anti Fungal
Anti Protozoal
Anti Viral
Vasodilator Agents
Anti Tumor agents
Immunomodulators
Research field: Inflamation
Signal to sort
C

Quote for

Price
$100.00
Concanamycin_A.gif
Concanamycin_A.gif

Oligomycin C

Oligomycin C
Molecular Formula
C45H74O10
M.W.
775.06
CAS number
11052-72-5
Source
Streptomyces diastatochromogenes
Fermentek product Code
OLC-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
195°C-205°C
Solubility test
Clear colorless solution at 5 mg/ml of Methanol or Acetonitrile
Names and identifiers

Synonyms: 12-Deoxyoligomycin A

Chemical names: Oligomycin C

IUPAC:

(1S,4E,5'R,6R,6'R,7S,8R,10S,11R,12R,14R,15R,16S,18E,20E,22S,25R,27S,28R,29S)-22-Ethyl-7,11,15-trihydroxy-6'-[(2S)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H- spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-pyran]-3,9,13-trione 

RTECS#  RK3335000

EU number
234-276-0
InChl Key
CMMLZMMKTYEOKV-RDKHTNMBSA-N
Canonical SMILES
CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)C)C)O)C)C)O)C)C
Isomeric SMILES
CC[C@@H]\1CC[C@H]2[C@H]([C@H]([C@@H]([C@]3(O2)CC[C@@H]([C@@H](O3)C[C@@H](C)O)C)C)OC(=O)/C=C/[C@@H]([C@H]([C@@H](C(=O)[C@@H]([C@H]([C@@H](C(=O)[C@H]([C@H]([C@@H](C/C=C/C=C1)C)O)C)C)O)C)C)O)C)C
Solubility ( literature )

Soluble in pure ethanol, in methanol, in DMF, and in DMSO.

 Not soluble in water

Compound Classification

Macrolide antibiotic

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Applications

inhibitor of cell regulatory volume decrease (RVD)

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Enzyme-inhibitors
Apoptosis related
Signal to sort
O

Quote for

Price
$1.00
Oligomycin_C.gif
Oligomycin_C.gif

Destruxin B

Destruxin B
Molecular Formula
C30H51N5O7
M.W.
593.76
CAS number
2503-26-6
Source
Metarhizium anisopliae
Fermentek product Code
DSB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-240°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane; Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Chemical names:

IUPAC:

RTECS# HH1500100

EU number
not on EC
Description

natural product

 

 

InChl Key
GNBHVMBELHWUIF-UHFFFAOYSA-N
Canonical SMILES
CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NCCC(=O)OC(C(=O)N2CCCC2C(=O)N1)CC(C)C)C)C)C(C)C)C
Compound Classification

chemical:

Natural cyclic depsipeptide 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
NDG
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Antibiotics
Research field: Cancer
Apoptosis related
Anti Tumor agents
Research area: Multi-drug resistance
Signal to sort
D

Quote for

Price
$1.00
Destruxin_B.gif
Destruxin_B.gif

Enniatin A

Enniatin A
Molecular Formula
C36H63N3O9
M.W.
681.90
CAS number
2503-13-1
Source
Fusarium sp.
Fermentek product Code
ENA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
121°C-125°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

Synonyms:

Chemical names:  Fusafungine ;   Enniatin-A

IUPAC: (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

A Fusarium produced depsipeptide ionophore

RTECS#  

Condensed IUPAC:  cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal]

EU number
215-737-5
Description

Enniatin A is a least abundant commponent of the Enniatin-complex. It has been recently made available as a pure compound, thanks to the most advanced preparative HPLC methods.

InChl Key
TWHBYJSVDCWICV-BHZTXFQCSA-N
Canonical SMILES
CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)CC)C)C(C)C)C(C)CC)C)C(C)C
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)[C@@H](C)CC)C)C(C)C)[C@@H](C)CC)C)C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMSO, DMF.

Compound Classification

Chemical classification:  Cyclic depsipeptide.

Biological classification:

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Natural enniatins occure as a mixture of several related analogs, known as "Enniatins", or "Enniatin complex". 

Enniatins occure in nature in the mycelia of some Fusarium species. Being cyclic and hydrophopic molecules, enniatins are able to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin has not previously been available for investigation.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
2503-13-1; 4530-29-4
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Immunomodulators
Ionophores
Signal to sort
E

Quote for

Price
$1.00
Enniatin_A.gif
Enniatin_A.gif

Veratridine

Veratridine
Molecular Formula
C36H51NO11
M.W.
673.79
CAS number
71-62-5
Source
Plant extract (Schoenocaulon officinale)
Fermentek product Code
VER-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-180°C
Solubility test
Clear colorless solution at 10mg/ml of DMSO or Methanol
Names and identifiers

Synonyms:   Veratrin (Amorphous)

Chemical names:  4,9-epoxycevane-3β,4α,12,14,16β,17,20-heptol 3-veratrate

IUPAC:   (3β,4α,16β)-4,12,14,16,17,20-Hexahydroxy-4,9-epoxycevan-3-yl 3,4-dimethoxybenzoate    

RTECS#  YX5600000

 

EU number
200-758-4
Description

Veratridine, plant-derived alkaloid is a potent modulator of voltage dependent Na+channels and hence, of transmitter release. Veratridine reduces the single channel conductance and increases the persistent opening propability.

InChl Key
FVECELJHCSPHKY-YFUMOZOISA-N
Canonical SMILES
CC1CCC2C(C3(C(CC4(C5CCC6C7(C5(CC4(C3CN2C1)O)OC6(C(CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
Isomeric SMILES
C[C@H]1CC[C@H]2[C@@]([C@]3([C@H](C[C@]4([C@@H]5CC[C@H]6[C@]7([C@]5(C[C@]4([C@@H]3CN2C1)O)O[C@@]6([C@H](CC7)OC(=O)C8=CC(=C(C=C8)OC)OC)O)C)O)O)O)(C)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
EU CN 29397990
Value
Alkaloids, natural or reproduced by synthesis, and their salts, ethers, esters and other derivatives; plant origin ; other;other
Title
CN FER 29419000
Value
Antibiotics other; other
Title
CN FER recommendation
Value
ONLY for research in the field of Cancer
Fermentek Product Category
Plant-derived
Research field: Cancer
Apoptosis related
Signal to sort
V

Quote for

Price
$1.00
Veratridine.gif
Veratridine.gif
Subscribe to Apoptosis related