Apoptosis is defined as a process of deliberate cell suicide in a multicellular organism. It is one of the main types of programmed cell death (PCD), and involves an orchestrated series of biochemical events leading to a characteristic cell morphology and death.

The apoptotic process is executed in such a way as to safely dispose of dead cells and fragments.

Apoptosis is a crucial element of the ontogenesis of multicellular organisms. Any aberration in it may lead to neoplastic events, to cancer and to death of the entire organism. Therefore, the Fermentek "Apoptosis related products” are of use in biological and medical research. Some have been the basis for the development of novel drugs.

Chaetoglobosin A

Chaetoglobosin A
Molecular Formula
C32H36N2O5
M.W.
528.64
CAS number
50335-03-0
MSDS
Source
Chaetomium globosum
Fermentek product Code
CHA-001
Brand/grade
For research
Appearance
Yellow to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
165°C-170°C
Solubility test
Clear yellow solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Chaetoglobosins;
  • Chaetoglobosin A;
  • CHAETOGLOBOSIN A;
  • CHAETOGLOBOSIN;
  • CHAETOGLOBOSINB;

Chemical names:

IUPAC:

(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trion e

 

RTECS#:

  • HA530500
EU number
not assigned
Chemical name
Chaetoglobosin A
Description

Antibiotic agent.

Phytotoxin. Cytochalasin analog

  • Targets filamentous actin and induces apoptosis.
  • Shows cytotoxic effects against cancer cell lines.
  • Shows antibacterial and nematicidal effects.
  • Induces tissue necrosis in vivo
InChl Key
OUMWCYMRLMEZJH-VOXRAUTJSA-N
Canonical SMILES
CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
Isomeric SMILES
C[C@H]1[C@H]2[C@@H](NC(=O)[C@@]23[C@@H](/C=C/CC(/C=C(/[C@H](C(=O)/C=C/C3=O)O)\C)C)[C@H]4[C@@]1(O4)C)CC5=CNC6=CC=CC=C65
Solubility ( literature )

Soluble in DMSO , Ethanol, Methanol

Compound Classification

Chemical classification:

  • Indole Alkaloids

Bioactivity classiification:

  • antibacterial
  • cytotoxic
  • Apoptosos inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS
Value
Rodent - rat; Oral LD50 - = >400 mg/kg
Signal to sort
C

Chaetocin

Chaetocin
Molecular Formula
C30H28N6O6S4
M.W.
696.84
CAS number
28097-03-2
Source
From Chaetomium sp
Fermentek product Code
CHT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 25 mg/ml DMSO
Names and identifiers

Synonyms

  • Chetocin
  • Chaetocin
  • (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone

RTECS: FM3032000

EU number
636-696-3
Description

A fungal metabolite which inhibits G9a histone methyltransferase.

InChl Key
PZPPOCZWRGNKIR-PNVYSBBASA-N
Canonical SMILES
CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Isomeric SMILES
c12c(N[C@@H]3N4[C@@]5(C[C@@]23[C@@]23c6c(N[C@@H]2N2[C@@]7(C3)C(N([C@@](C2=O)(SS7)CO)C)=O)cccc6)C(N([C@@](CO)(C4=O)SS5)C)=O)cccc1
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
31794-18-0
Title
Inhibitor of:
Value
G9a histone methyltransferase
Title
Transport information
Value
Not hazardous for transport
Title
Research Areas
Value
HIV
Signal to sort
C

Dimethylamino Parthenolide (DMAPT)

Dimethylamino Parthenolide (DMAPT)
Molecular Formula
C17H27NO3
M.W.
293.40
CAS number
795195-09-7
Source
Synthetic
Fermentek product Code
DMP-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
145°C-153°C
Solubility test
Clear colorless solution at 10 mg/ml Ethanol or DMSO or Dichloromethane.
Description

DMAPT is water soluble semi-synthetic derivate of Parthenolide.

InChl Key
UJNSFDHVIBGEJZ-ONGJMVGKSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(C(=O)O3)CN(C)C)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@@H](O2)[C@@H]3[C@@H](CC1)[C@@H](C(=O)O3)CN(C)C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid moisture.
Retest time
3 Years
Applications

DMAPT has been reported as antiviral, anti HIV, anti Hepatitis C virus

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Signal to sort
D

Thapsigargin

Thapsigargin
Molecular Formula
C34H50O12
M.W.
650.75
CAS number
67526-95-8
MSDS
Source
Thapsia garganica
Fermentek product Code
THP-001
Brand/grade
For research
Appearance
White to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Acetonitrile
Names and identifiers

Synonyms: octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester

RTECS  RH0352700 

EU number
614-076-3
Description

Thapsigargin is a cell-permeable, tumor promoting sesquiterpene lactone. A tight-binding inhibitor of intracellular calcium (SERCA) pumps (sarco/endoplasmic reticulum Ca2+ ATPase). Chemically it is classified as a sesquiterpene lactone antibiotic.

A study from the University of Nottingham showed promising results for its use against Covid-19 and other coronavirus.

 

InChl Key
IXFPJGBNCFXKPI-FSIHEZPISA-N
Canonical SMILES
CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
Isomeric SMILES
CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
Solubility ( literature )

DMSO, Acetonitril, Ethanol, Methanol, Dichloromethane

Compound Classification
  • Sesquiterpene lactone
  • SERCA inhibitor
  • Apoptosis related antibiotic
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
TSE category
Value
V
Signal to sort
T

Tenuazonic acid (Cu salt)

Tenuazonic acid – Copper salt
Molecular Formula
C20H28CuN2O6
M.W.
455.99
CAS number
76569-74-9
MSDS
Source
Alternaria sp.
Fermentek product Code
TNZ-001
Brand/grade
For research
Appearance
Light blue-greenish powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear blue-green solution at 10mg/ml Dichloromethane
Names and identifiers

Synonyms:

  • 3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

RTECS: UY7425000
 

 

Description

Tenuazonic acid is a natural mycotoxin, inhibitor of protein synthesis. Tenuazonic acid is offered as its Cuprum salt. 

 

InChl Key
LLXUERDQXVXQAY-UHFFFAOYSA-N
Canonical SMILES
CCC(C)C1C(=C(C(=O)N1)C(=O)C)O.CCC(C)C1C(=C(C(=O)N1)C(=O)C)O.[Cu]
Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification
  • Pyrrolidinone mycotoxin
  • Tenuazonic Acid Copper Salt is an antineoplastic agent and mycotoxin. It Inhibits protein synthesis, though which it has been shown inhibiting TPA-induced ornithine decarboxylase activity. Lack of ornithine decarboxylase has been shown to eventually cause DNA damage induced apoptosis. It has also been shown to inhibit photosystem II.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

This is a potential antineoplastic agent

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since

T2 Toxin

Molecular Formula
C24H34O9
M.W.
466.52
CAS number
21259-20-1
MSDS
Source
Fusarium tricinctum
Fermentek product Code
T2T-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml Dichloromethane
Names and identifiers

Synonyms

  • Fusariotoxin T2
  • T2 TOXIN
  • MYCOTOXIN T2
  • 8-(3-Methylbutyryloxy)-diacetoxyscirpenol
  • Trichothec-9-ene-3.alpha.,8.alpha.,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate

RTECS: YD0100000

 

EU number
244-297-7
Chemical name
T2 TOXIN
Description

T2 Toxin: A trichothecene group mycotoxin, of the most important Fusarium toxins.

InChl Key
BXFOFFBJRFZBQZ-QYWOHJEZSA-N
Canonical SMILES
CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Ethyl Acetate. Slightly soluble in petroleum ether; very slightly soluble in water.

Compound Classification

Trichothecene Mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

T-2 toxin has been reported to be used to increase blood-brain barrier permeability in rats.

T-2 Toxin induces DNA damage and cell death on prolonged administration.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Signal to sort
T

Staurosporine

Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Signal to sort
S

Puromycin dihydrochloride

Puromycin dihydrochloride
Molecular Formula
C22H29N7O5·(HCl)2
M.W.
544.43
CAS number
58-58-2
MSDS
Source
Streptomyces alboniger
Fermentek product Code
PUR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
≥160°C (dec.)
Solubility test
Clear, slightly brown solution at 50mg/ml of water
Names and identifiers

Synonyms: 

  • Stylomycin
  • Achromycin

IUAPC name: 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine dihydrochloride

RTECS AU7355000

EU number
200-388-3
Chemical name
Adenosine, 3'-​[[(2S)​-​2-​amino-​3-​(4-​methoxyphenyl)​-​1-​oxopropyl]​amino]​-​3'-​deoxy-​N,​N-​dimethyl-​, hydrochloride (1:2)
Description

Puromycin is a protein synthesis inhibitor. It causes premature chain termination.

InChl Key
RYSMHWILUNYBFW-UHFFFAOYSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)N)O
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Compound Classification
  • Nucleoside antibiotic.
  • Protein synthesis inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Puromycin is an antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase. Puromycin is also a Antineoplastic agent. Puromycin possesses antoprotozoal activities (against Trypanozoma)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Puromycin is available also in "Animal-Free version", please inquire.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
RTECS verified toxicity LD50 oral mouse
Value
LD50 720 mg/ml
Signal to sort
P

Puromycin Aminonucleoside

Puromycin Aminonucleoside
Molecular Formula
C12H18N6O3
M.W.
294.30
CAS number
58-60-6
MSDS
Source
Semisynthetic (from Puromycin)
Fermentek product Code
PAN-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear colorless solution at 50 mg/ml DMSO;
Clear colorless solution at 10 mg/ml water
Names and identifiers

RTECS: AU7337000

EU number
200-387-8
Description

Puromycin Aminonucleoside is a puromycin analog which does not inhibit protein synthesis or induce apoptosis

InChl Key
MKSVFGKWZLUTTO-FZFAUISWSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Solubility ( literature )

Water

Compound Classification
  • Nucleoside antibiotic
  • Protein synthesis inhibitor

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
28315-29-9 ; 54833-68-0 ; 136680-68-7
Title
Transport information
Value
Not hazardous for transport
Signal to sort
P

Patulin

Patulin
Molecular Formula
C7H6O4
M.W.
154.10
CAS number
149-29-1
MSDS
Source
Penicillium expansum
Fermentek product Code
PAT-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
105°C-113°C
Solubility test
Clear colorless solution at 10mg/ml DMSO
Names and identifiers

Synonyms:

  • Clavacin
  • Claviformin
  • Mycoin
  • Penicidin
  • Expansin
  • Leucopin
  • Gigantin

IUPAC name: 4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

HSDB: 3522

RTECS#: LV2625000

EU number
205-735-2
Description

Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase.

InChl Key
ZRWPUFFVAOMMNM-UHFFFAOYSA-N
Canonical SMILES
C1C=C2C(=CC(=O)O2)C(O1)O
Solubility ( literature )

Patulin is soluble in DMSO, Methanol, Ethanol, water

Compound Classification
  • Lactone Mycotoxin
  • Cell signaling reagent;
  • apopotosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Retest time
3 Years
Applications

Patulin was suggested as a remedy against common cold and reached clinical trials step in 1943 in Great Britain. However Patulin was found to be inefficient as such.(International Journal of Epidemiology 2004;33:243–246)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Signal to sort
P