Thapsigargin
Molecular Formula
C34H50O12
M.W.
650.75
CAS number
67526-95-8
MSDS
Source
Thapsia garganica
Fermentek product Code
THP-001
Brand/grade
For research
Appearance
White to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Acetonitrile
Names and identifiers

Synonyms: octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester

RTECS  RH0352700 

EU number
614-076-3
Description

Thapsigargin is a cell-permeable, tumor promoting sesquiterpene lactone. A tight-binding inhibitor of intracellular calcium (SERCA) pumps (sarco/endoplasmic reticulum Ca2+ ATPase). Chemically it is classified as a sesquiterpene lactone antibiotic.

A study from the University of Nottingham showed promising results for its use against Covid-19 and other coronavirus.

 

InChl Key
IXFPJGBNCFXKPI-FSIHEZPISA-N
Canonical SMILES
CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O
Isomeric SMILES
CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
Solubility ( literature )

DMSO, Acetonitril, Ethanol, Methanol, Dichloromethane

Compound Classification
  • Sesquiterpene lactone
  • SERCA inhibitor
  • Apoptosis related antibiotic
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
TSE category
Value
V
Signal to sort
T