Puromycin dihydrochloride
Molecular Formula
C22H29N7O5·(HCl)2
M.W.
544.43
CAS number
58-58-2
MSDS
Source
Streptomyces alboniger
Fermentek product Code
PUR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
≥160°C (dec.)
Solubility test
Clear, slightly brown solution at 50mg/ml of water
Names and identifiers

Synonyms: 

  • Stylomycin
  • Achromycin

IUAPC name: 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine dihydrochloride

RTECS AU7355000

EU number
200-388-3
Chemical name
Adenosine, 3'-​[[(2S)​-​2-​amino-​3-​(4-​methoxyphenyl)​-​1-​oxopropyl]​amino]​-​3'-​deoxy-​N,​N-​dimethyl-​, hydrochloride (1:2)
Description

Puromycin is a protein synthesis inhibitor. It causes premature chain termination.

InChl Key
RYSMHWILUNYBFW-UHFFFAOYSA-N
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)N)O
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Compound Classification
  • Nucleoside antibiotic.
  • Protein synthesis inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Other vendors may recommend higher temperatures for storage.
Applications

Puromycin is an antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase. Puromycin is also a Antineoplastic agent. Puromycin possesses antoprotozoal activities (against Trypanozoma)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Puromycin is available also in "Animal-Free version", please inquire.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
RTECS verified toxicity LD50 oral mouse
Value
LD50 720 mg/ml
Signal to sort
P