Chaetoglobosin A
Molecular Formula
C32H36N2O5
M.W.
528.64
CAS number
50335-03-0
MSDS
Details
Source
Chaetomium globosum
Fermentek product Code
CHA-001
Brand/grade
For research
Specifications
Appearance
Yellow to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
165°C-170°C
Solubility test
Clear yellow solution at 10mg/ml of Methanol
Chemical identification
Names and identifiers
Synonyms:
- Chaetoglobosins;
- Chaetoglobosin A;
- CHAETOGLOBOSIN A;
- CHAETOGLOBOSIN;
- CHAETOGLOBOSINB;
Chemical names:
IUPAC:
(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trion e
RTECS#:
- HA530500
EU number
not assigned
Chemical name
Chaetoglobosin A
Description
Antibiotic agent.
Phytotoxin. Cytochalasin analog
- Targets filamentous actin and induces apoptosis.
- Shows cytotoxic effects against cancer cell lines.
- Shows antibacterial and nematicidal effects.
- Induces tissue necrosis in vivo
InChl Key
OUMWCYMRLMEZJH-VOXRAUTJSA-N
Canonical SMILES
CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
Isomeric SMILES
C[C@H]1[C@H]2[C@@H](NC(=O)[C@@]23[C@@H](/C=C/CC(/C=C(/[C@H](C(=O)/C=C/C3=O)O)\C)C)[C@H]4[C@@]1(O4)C)CC5=CNC6=CC=CC=C65
Further Information
Solubility ( literature )
Soluble in DMSO , Ethanol, Methanol
Compound Classification
Chemical classification:
- Indole Alkaloids
Bioactivity classiification:
- antibacterial
- cytotoxic
- Apoptosos inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS
Value
Rodent - rat; Oral LD50 - = >400 mg/kg
Fermentek Product Category
Signal to sort
C
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