Staurosporine

Molecular Formula

C28H26N4O3

M.W.

466.53

CAS number

62996-74-1

MSDS

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Details

Source

Streptomyces staurosporeus

Fermentek product Code

STA-001

Specifications

Appearance

Off-white to light yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

255°C-275°C

Solubility test

Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO

Chemical identification

Names and identifiers

Synonyms: Antibiotic AM 2282;

RTECS: KD5084000 ; attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number

613-127-7

Chemical name

Staurosporine

Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C. Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key

HKSZLNNOFSGOKW-FYTWVXJKSA-N

Canonical SMILES

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Isomeric SMILES

C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Further Information

Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification

Chemical classification: Indolocarbazole alkaloid
Bio-activity: PKC inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
May participate in antigen-induced T-cell activation;
Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Supply related information

Shipped at ambient temperature

Shipped in PP / PE bottle.

Special Info