Apoptosis is defined as a process of deliberate cell suicide in a multicellular organism. It is one of the main types of programmed cell death (PCD), and involves an orchestrated series of biochemical events leading to a characteristic cell morphology and death.

The apoptotic process is executed in such a way as to safely dispose of dead cells and fragments.

Apoptosis is a crucial element of the ontogenesis of multicellular organisms. Any aberration in it may lead to neoplastic events, to cancer and to death of the entire organism. Therefore, the Fermentek "Apoptosis related products” are of use in biological and medical research. Some have been the basis for the development of novel drugs.

Antimycin A (complex)

Antimycin A (complex)
Molecular Formula
C28H40N2O9 (for Antimycin A1)
M.W.
548.62
CAS number
1397-94-0
MSDS
Source
Streptomyces sp.
Fermentek product Code
ANT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% (a mixture of subunits) ; refer to CoA for more data
Melting point
135°C-144°C
Solubility test
Clear colorless solution at 50mg/ml of Ethanol (slight heating)
Names and identifiers

Synonyms:

  • Antimycin  A
  • Antimycins A
  • Antipiricullin
  • Fintrol
  • Virosin

Chemical names:

IUPAC:  3-[(3-Formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl 3-methylbutanoate

RTECS#  CD0350000

EU number
634-284-8
Description

Antimycin A is a complex of related macrocyclic lactones, predominantly A1 to A4, isolated from several species of Streptomyces, first reported in the early 1950s for potent antifungal activity. There are over 20 known analogues in the antimycin A class, mostly involving variation of the fatty acid ester chain length or adjacent alkyl starting unit. Antimycin A binds to cytochrome C reductase at the Qi site, inhibiting the oxidation of ubiquinol to ubiquinone. Antimycin A is widely used as a bioprobe of respiration and other applications with over 5,000 literature citations.

Some of data brought in this page, such as Molecular Weight, relates to Antimycin A1

 

 

InChl Key
UIFFUZWRFRDZJC-RBVQMQRASA-N
Canonical SMILES
CCCCCCC1C(C(OC(=O)C(C(OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Isomeric SMILES
CCCCCCC1[C@H]([C@@H](OC(=O)[C@H]([C@H](OC1=O)C)NC(=O)C2=C(C(=CC=C2)NC=O)O)C)OC(=O)CC(C)C
Solubility ( literature )

(lit) Antimycin A is soluble in DMSO at 2 mg/mL and in 95% ethanol at 50 mg/mL. It is also freely soluble in ether, acetone, and chloroform. It is insoluble in water.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
CN code
Value
29419000
Title
Deleted CAS Numbers
Value
37330-19-1; 50858-98-5
Title
special link
Value
www.cdc.gov/niosh-rtecs/CD55730.html
Title
toxicity by RTECS
Value
LD50 Oral rat = 28 mg/kg; mouse oral 55 mg/kg;
Title
PG
Value
2
Title
Eco-toxicity
Value
very toxic to bone fish
Title
TSCA
Value
on extremely hazardous subst list
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Anti Tumor agents
Signal to sort
A

Quote for

Price
$100.00
Ansamitocin_P3.gif
Ansamitocin_P3.gif

Withaferin A

Withaferin A
Molecular Formula
C28H38O6
M.W.
470.60
CAS number
5119-48-2
Source
Withania somnifera (a plant)
Fermentek product Code
WIT-001
Appearance
White to off-white or slightly yellow crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
225°C-235°C
Solubility test
Clear colorless solution at 20 mg/ml DMSO;
Clear colorless solution at 10 mg/ml Methanol
Names and identifiers

Synonyms

  • Withaferin E
  • 5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone

RTECS: KE7288500

 

EU number
Not available (as at June 2019)
Chemical name
Withaferin A
Description

Withaferin A is a cell-permeable steroidal lactone from a medicinal plant Withania somnifera, a plant known in traditional Indian medicine.

InChl Key
DBRXOUCRJQVYJQ-CKNDUULBSA-N
Canonical SMILES
CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO
Isomeric SMILES
CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO
Solubility ( literature )

Methanol, Ethanol, DMSO

Compound Classification
  • Ergosterol analog
  • inhibitor of angiogenesis
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Withaferin A has shown significant anticancer activity in animal studies. Withaferin A is an angiogenesis inhibitor . Withaferin A has immunomodulating properties. Withaferin A has radiosensitizing effect on cancer cells. Withaferin A has been reported to induce neuronal regeneration.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein kinase related
Signal to sort
W

Quote for

Price
$1.00
Withaferin_A.gif
Withaferin_A.gif

Roridin E

Roridin E
Molecular Formula
C29H38O8
M.W.
514.61
CAS number
16891-85-3
MSDS
Source
Myrothecium sp.
Fermentek product Code
ROE
Brand/grade
For research
Purity by HPLC
≥ 98% ; refer to CoA for more data
Purity By TLC
≥ 98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or DMSO
Names and identifiers

Synonyms:

  • Roridin E
  • Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxyethyl)-, (2'E,7'R(R))-

Chemical names:

IUPAC:  Verrucarin A, 2',3'-didehydro-7'-deoxo-2'-deoxy-7'-(1-hydroxyethyl)-, (2'E,7'R(R))-(1R,3R,8R,12E,17R,18E,20Z,24R,25S,26S)-17-[(1R)-1-hydroxyethyl]-5,13,25-trimethylspiro[2,10,16,23-tetraoxatetracyclo[22.2.1.03,8.08,25]heptacosa-4,12,18,20-tetraene-26,2'-oxirane]-11,22-dione

T3DB: T3D3711

RTECS# YX9821500

Description

Roridin E is trichothecene toxin produced by molds from Fusarium, Myrothecium, and Stachybotrys genera. 

InChl Key
KEEQQEKLEZRLDS-FLGSVKSYSA-N
Canonical SMILES
CC1=CC2C3(CC1)COC(=O)C=C(CCOC(C=CC=CC(=O)OC4C3(C5(CO5)C(C4)O2)C)C(C)O)C
Isomeric SMILES
CC1=C[C@@H]2[C@@]3(CC1)COC(=O)/C=C(/CCO[C@H](/C=C/C=C\C(=O)O[C@H]4[C@]3([C@]5(CO5)[C@@H](C4)O2)C)[C@@H](C)O)\C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Shipped at ambient temperature
Available since
Fermentek Product Category
Food Safety
Mycotoxins
Trichocothecenes
Cytotoxic agents
Apoptosis related
Protein synthesis inhibitors
Protein kinase related
Anti Parasitic
Anti Viral
Signal to sort
R

Quote for

Price
$1.00
RORIDIN E
RORIDIN E

Prodigiosin hydrochloride

Prodigiosin hydrochloride
Molecular Formula
C20H25N3O·HCl
M.W.
359.89
CAS number
56144-17-3
MSDS
Source
Serratia marcescens
Fermentek product Code
PRD-001
Brand/grade
For research
Appearance
Dark Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml of Methanol, Clear red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Disambiguation:    Do not confuse with Prodigiozan, another antibiotic from the same source.

Chemical names:   2,​2'-​Bi-​1H-​pyrrole, 4-​methoxy-​5-​[(5-​methyl-​4-​pentyl-​2H-​pyrrol-​2-​ylidene)​methyl]​-​, hydrochloride (1:1)

IUPAC:                    (2Z)-3-methoxy-2-[(5-methyl-4-pentyl-1H-pyrrol-2-yl)methylidene]-5-(1H-pyrrol-2-yl)pyrrole;hydrochloride

RTECS                     DW2977000   refers to prodigiosin free base 

EU number
Not listed
Chemical name
4-Methoxy-5-[(E)-(5-methyl-4-pentyl-2H-pyrrol-2-ylidene)methyl]-1H,1'H-2,2'-bipyrrole
Merck index
14: 7767
Description

Prodigiosin is a antibiotic from Serratia marcescens and some other bacterial species. It displays a wide range of biological activities, making it a promissing candidate drug. Among these are antimalarial, antifungal, anti-cancer, immunosuppressant, and antibiotic properties.

InChl Key
UQRGJSTXVCWXNU-JHMJKTBASA-N
Canonical SMILES
CCCCCC1=C(NC(=C1)C=C2C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Isomeric SMILES
CCCCCC1=C(NC(=C1)/C=C/2\C(=CC(=N2)C3=CC=CN3)OC)C.Cl
Solubility ( literature )

(Data from literature including scientific publications and books, patents and other vendors)

Prodigiosin is soluble in acetonitrile, ethanol, methanol, chloroform, and DMSO. It is insoluble in water.

Compound Classification

UNSPSC

  • 51000000  Drugs and Pharmaceutical Products
  • 51200000  Immunomodulating drugs
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

For research only!

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
depreciated CAS
Value
30814-03-0; 47371-61-9;
Title
Transport
Value
NDG
Fermentek Product Category
Antibiotics
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Mitotic
Anti Fungal
Anti Protozoal
Anti Parasitic
Anti Bacterial
Anti Tumor agents
Immunosupressors
Signal to sort
P

Quote for

Price
$1.00

Aloe-emodin

Aloe-emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
481-72-1
MSDS
Source
Aloe Vera (extracted from plant)
Fermentek product Code
ALO-001
Brand/grade
For research
Appearance
Brownish-orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
218°C-225°C
Solubility test
Clear orange solution at 50 mg/ml of DMSO
Names and identifiers

Synonyms:

* Aloe-emodin
* 9,10-Anthracenedione, 1,8-dihydroxy-3-(hydroxymethyl)-
* 1,8-Dihydroxy-3-(hydroxymethyl)-9,10-anthracenedione
* 1,8-Dihydroxy-3-hydroxymethylanthraquinone
* 3-Hydroxymethylchrysazin
* Rhabarberone

 

RTECS : CB6712200

 

EU number
207-571-7
Description

Aloe-emodin is a hydroxyanthraquinone found naturally in Aloe vera and in other aloe plants. It exhibits antibacterial, antiviral, anti-inflammatory and hepatoprotective effects. recently it gains interest as a candidate anti-cancer agent.

InChl Key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)CO
Compound Classification

 An anthraquinone compound from Aloe Vera and other plants.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Aloe-emodin is a drug candidate for cancer therapy.

  • It induces apoptosis in human oral squamous cell carcinoma SCC15 cells ;
  • It exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential
  • It induced DNA damage and inhibited DNA repair gene expression in SCC-4 human tongue cancer cells.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
from RTECS
Value
Mutagen in bacteria and mammalian cell cultures
Fermentek Product Category
Plant-derived
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein kinase related
Cancer Related Compounds
Anti Tumor agents
Research area: Multi-drug resistance
Research Area: Stem Cells
Signal to sort
A

Quote for

Price
$10,000.00
Aloe_Emodin
Aloe_Emodin

Bongkrekic acid (as solution)

Bongkrekic acid (as solution)
Molecular Formula
C28H38O7
M.W.
486.60
CAS number
11076-19-0
MSDS
Source
Pseudomonas gladioli
Fermentek product Code
BON-001
Brand/grade
For research
Appearance
Clear colorless solution
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Names and identifiers

Synonyms:

  • Bongkrekic Acid
  • Flavotoxin A

Chemical names:

IUPAC:

  • (6R,17S)-20-(carboxymethyl)-6-methoxy-2,5,17-trimethyldocosa-2,4,8,10,14,18,20-heptaenedioic acid

RTECS    

EU number
Not assigned
Chemical name
Bongkrekic acid
Description

Supplied as 1mg/ml solution dissolved in 0.01M Tris buffer pH 7.5. 

InChl Key
SHCXABJSXUACKU-WUTQZGRKSA-N
Canonical SMILES
CC(CC=CCCC=CC=CCC(C(=CC=C(C)C(=O)O)C)OC)C=CC(=CC(=O)O)CC(=O)O
Isomeric SMILES
CC(C/C=C/CC/C=C/C=C\CC(/C(=C\C=C(/C)\C(=O)O)/C)OC)/C=C/C(=C\C(=O)O)/CC(=O)O
Solubility ( literature )
  • Solubility in Water: ~ 1 mg/ml
  • Solubility Notes: ~100 mg/ml in DMSO
Compound Classification
  • Chemical classification:
  • Polyunsaturated tricarboxylic acid

Bioactivity:

  • Glutathione transferase inhibitor
  • ATP/ADP translocase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Applications

 Bongcrekic acid is an inhibitor of adenine nucleotide translocator, which inhibits apoptosis, and is thus an important tool for the mechanistic investigation of apoptosis.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Ingredient amount
1 mg/ml in 0.01M Tris buffer pH 7.5
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
CAS ambiguity
Value
# 60132-21-0 belongs to Isobongkrekic acid . http://www.molbase.com/en/cas-60132-21-0.html
Title
oral LD50
Value
oral LD50 of the purified Flavotoxin A in mice 3.16 mg/kg
Title
More identity comments; Hu WJ et al; Biomed Environ Sci 2 (1): 65-71 (1989)
Value
Therefore, Flavotoxin A and bongkrekic acid are the same organic chemical compound; the molecular formula is C28H38O7. The oral LD50 of the purified Flavotoxin A in mice was 3.16 mg/kg (1.53-6.15 mg/kg).
Title
Deleted CAS Registry Numbers
Value
11002-93-0, 12715-13-8, 32839-39-7
Title
oral LD50
Value
ANOTHER SOURCE: MOUSE LDL0=6.85 mg/kg PMID:6391376
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Cytotoxic agents
Enzyme-inhibitors
Apoptosis related
Anti Fungal
Anti Bacterial
Anti Tumor agents
Signal to sort
B

Quote for

Price
$100.00
Bongkrekic_acid.gif
Bongkrekic_acid.gif

Shikonin

Shikonin
Molecular Formula
C16H16O5
M.W.
288.30
CAS number
517-89-5
MSDS
Source
Alkanna sp.
Fermentek product Code
SHA-001
Brand/grade
For research
Appearance
Bordeaux brown powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 1mg/ml of Methanol;
Clear dark red solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Shikonin
  • Isoarnebin 4
  • Tokyo Violet
  • Shikonin S
  • 5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone
  • HSDB 8100

Chemical names:  Shikonin

IUPAC:  5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione

RTECS#:   QL8000200

 
EU number
610-730-7
Description

A naphthoquinone extracted from  Lithospermum erythrorhizon.

InChl Key
NEZONWMXZKDMKF-SNVBAGLBSA-N
Canonical SMILES
CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Isomeric SMILES
CC(=CC[C@H](C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
Compound Classification

UNSPSC 41116011  

E - Medical, Laboratory & Test Equipment & Supplies & Pharmaceuticals

  • 41000000 - Laboratory and Measuring and Observing and Testing Equipment
  • 41110000 - Measuring and observing and testing instruments
  • 41116000 - Clinical and diagnostic analyzer reagents analyzer reagents
  • 41116011 - Microbiology analyzer reagents
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gm/kg
Title
Deleted CAS Registry Numbers
Value
874325-10-7; 876010-87-6
Fermentek Product Category
Plant-derived
Pyruvate kinase inhibitor
pyruvate kinase M2 specific inhibitor
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Mitotic
Anti Bacterial
Anti Tumor agents
Research field: Inflamation
Signal to sort
S

Quote for

Price
$411.00
Shikonin-517-89-5
Shikonin.gif
Shikonin-517-89-5
Shikonin.gif

Emodin

Emodin
Molecular Formula
C15H10O5
M.W.
270.24
CAS number
518-82-1
MSDS
Fermentek product Code
EMO-001
Brand/grade
For research
Appearance
Orange Powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-265°C
Solubility test
Clear yellow to red solution at 50mg/ml of DMSO;
Clear yellow to red solution at 10mg/ml of Ethanol (may need a little warming)
Names and identifiers

Synonyms

  • Archin
  • Emodol
  • Frangula emodin
  • Frangulic acid
  • Rheum emodin

 Chemical names    Emodin

RTECS                    CB7920600

EU number
208-258-8
Chemical name
Emodin
Description

 Emodin is an anthraquinone class compound. It is sourced from a plant Rheum palmatum. It exhibits antibacterial, anti-neoplastic, anti-inflammatory and anti-angiogenesis properties. 

InChl Key
RHMXXJGYXNZAPX-UHFFFAOYSA-N
Canonical SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)O
Solubility ( literature )

Water Solubility <0.1 g/100 mL at 19ºC ; Practically insoluble in water; soluble in alcohol, aqueous alkali hydroxide solutions (cherry red color), (src: Merck index)

Compound Classification

Emodin has been investigated for the treatment of Polycystic Kidney.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
phys appearance
Value
Emodin appears as orange needles or powder.
Title
CN EU 29146980
Value
Ketones and quinones; Quinones; Other; Other
Title
Usage:
Value
Only for research in the field of cancer
Title
Usage:
Value
Emodin has been investigated for the treatment of Polycystic Kidney
Fermentek Product Category
Plant-derived
Antibiotics
Angiogenesis related
Apoptosis related
Protein kinase related
Cardiovascular agents
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Immunosupressors
Research field: Inflamation
Signal to sort
E

Quote for

Price
$10,000.00
Emodin.gif
Emodin.gif

Puromycin dihydrochloride animal free

Puromycin dihydrochloride animal free
Molecular Formula
C22H29N7O5·(HCl)2
M.W.
471.52
CAS number
58-58-2
MSDS
Source
Streptomyces alboniger
Fermentek product Code
PUR-002
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
≥160°C (dec.)
Solubility test
Clear, slightly brown colorless solution at 50mg/ml of Water
Names and identifiers

Synonyms: 

  • Stylomycin
  • Achromycin

Chemical names:

IUAPC name: 3'-deoxy-N,N-dimethyl-3'-[(O-methyl-L-tyrosyl)amino]adenosine dihydrochloride

RTECS#  AU7355000

EU number
200-388-3
Chemical name
Adenosine, 3'-​[[(2S)​-​2-​amino-​3-​(4-​methoxyphenyl)​-​1-​oxopropyl]​amino]​-​3'-​deoxy-​N,​N-​dimethyl-​, hydrochloride (1:2)
Description
  • This version of Puromycin has been prepared without using animal raw materials.
  • Puromycin is a protein synthesis inhibitor. It causes premature chain termination.
InChl Key
C22H29N7O5·(HCl)2
Canonical SMILES
CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)N)O
Isomeric SMILES
CN(C)C1=NC=NC2=C1N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)NC(=O)[C@H](CC4=CC=C(C=C4)OC)N)O.Cl.Cl
Compound Classification
  • Nucleoside antibiotic.
  • Protein synthesis inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Puromycin is an antibiotic used for selecting mammalian cell lines, which have been transformed by vectors that express puromycin-N-acetyl-transferase. Puromycin is also a Antineoplastic agent. Puromycin possesses antoprotozoal activities (against Trypanozoma)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotAnimal

No animal ingredients

NotGMO

Product natural

Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Antib-29419000
Available since
Title
EC safety - REACH; preregistered ; ANNEX III
Value
suspected : carcinogen, mutagen, toxic for reproduction
Fermentek Product Category
Antibiotics
Apoptosis related
Anti Bacterial
Signal to sort
P

Quote for

Price
$100,000.00
Puromycin_dihydrochloride_Animal_Free.gif
Puromycin_dihydrochloride_Animal_Free.gif

Celastrol (Tripterin)

Celastrol (Tripterin)
Molecular Formula
C29H38O4
M.W.
450.61
CAS number
34157-83-0
MSDS
Source
Tripterygium wilfordii
Fermentek product Code
CEL-001
Brand/grade
For research
Appearance
Red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-220°C
Solubility test
Clear red solution at 10mg/ml DMSO,
Clear red solution at 10mg/ml Ethanol
Names and identifiers

Synonyms:

  • Tripterin
  • Celastrol

Chemical names:

RTECS: YJ7900000

 
EU number
636-472-5
Description

Celastrol is a chemical compound isolated from the root extracts of Tripterygium wilfordii and Celastrus regelii. Celastrol is a pentacyclic triterpenoid and belongs to the family of quinone methides. In mice, celastrol increases expression of IL1R1, which is the receptor for the cytokine interleukin-1. Celastrol is an antioxidant, anti-inflammatory and immunosuppressive agent. 

InChl Key
KQJSQWZMSAGSHN-JJWQIEBTSA-N
Canonical SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
Isomeric SMILES
CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)O)C)C)C)C)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Protect from moisture!
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
HSP90 inhibitors
Angiogenesis related
Apoptosis related
Anti Viral
Anti Tumor agents
Research field: Inflamation
Research field: Signal Transduction
Signal to sort
T

Quote for

Price
$10,000.00
Celastrol__Tripterin_.gif
Celastrol__Tripterin_.gif
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