Withaferin A

Molecular Formula

C28H38O6

M.W.

470.60

CAS number

5119-48-2

Details

Source

Withania somnifera (a plant)

Fermentek product Code

WIT-001

Specifications

Appearance

White to off-white or slightly yellow crystalline solid.

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

225°C-235°C

Solubility test

Clear colorless solution at 20 mg/ml DMSO;
Clear colorless solution at 10 mg/ml Methanol

Chemical identification

Names and identifiers

Synonyms

Withaferin E
5,6-epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dienoic acid delta-lactone

RTECS: KE7288500

EU number

Not available (as at June 2019)

Chemical name

Withaferin A

Description

Withaferin A is a cell-permeable steroidal lactone from a medicinal plant Withania somnifera, a plant known in traditional Indian medicine.

InChl Key

DBRXOUCRJQVYJQ-CKNDUULBSA-N

Canonical SMILES

CC1=C(C(=O)OC(C1)C(C)C2CCC3C2(CCC4C3CC5C6(C4(C(=O)C=CC6O)C)O5)C)CO

Isomeric SMILES

CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO

Further Information

Solubility ( literature )

Methanol, Ethanol, DMSO

Compound Classification

Ergosterol analog
inhibitor of angiogenesis

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Retest time

3 Years

Applications

Withaferin A has shown significant anticancer activity in animal studies. Withaferin A is an angiogenesis inhibitor . Withaferin A has immunomodulating properties. Withaferin A has radiosensitizing effect on cancer cells. Withaferin A has been reported to induce neuronal regeneration.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2008