Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

Valinomycin

Valinomycin
Molecular Formula
C54H90N6O18
M.W.
1 111.32
CAS number
2001-95-8
MSDS
Source
Streptomyces fulvissimus
Fermentek product Code
VAL-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
186°C-190°C
Solubility test
Clear colorless solution at 50mg/ml Dicloromethane or DMSO
Names and identifiers

Synonyms: Potassium ionophore I

HSDB: 6423

EINECS: 217-896-6

RTECS: YV9468000

EU number
217-896-6
Description

Valinomycin is a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and chemically related to the enniatins.

 

InChl Key
FCFNRCROJUBPLU-UHFFFAOYSA-N
Canonical SMILES
CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
Isomeric SMILES
C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
Compound Classification

cyclic oligopeptide Ionophore

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Being a Potassium selective ionophore, valinomycin is used in specific potassium measurment electrodes.Valinomycin is an apoptosis inducer. It is used as a tool in membrane research.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Hazard. Pg I
Title
Deleted CAS numbers
Value
134-16-7; 11005-80-4; 32398-05-3
Title
Inventory Status canada
Value
On NDSL Canada Gazette, Part I, January 31, 1998
Title
regulatory india
Value
List of Hazardous Chemicals, 2000.
Title
regulatory USA
Value
40 CFR Part 302 ; 40 CFR Part 355
Fermentek Product Category
Antibiotics
Anti Bacterial
Ionophores
Signal to sort
V

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Price
$1.00
Valinomycin.gif
Valinomycin.gif

Tunicamycin (complex)

Tunicamycin (complex)
Molecular Formula
C39H64N4O16 (for n=10, "Tunicamycin VII")
CAS number
11089-65-9
MSDS
Source
Streptomyces chartreusis
Fermentek product Code
TUN-001
Brand/grade
For research
Appearance
Off white to tan powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
4 spots matching standard, no other spots, by multiple methods.
Melting point
≥210°C
Solubility test
Clear solution at 5mg/ml of Methanol,
Clear solution at 50mg/ml of DMSO
Names and identifiers

RTECS: YO7980200

EU number
601-012-4
Description

Tunicamycin is a mixture of homologous nucleoside antibiotics.
The main homologs differ in the length of the fatty chain moiety.
The following table defines the four main Tunicamycin homologs.

  • Tunicamycin A, aka Tunicamycin V, n=9, mw=817;
  • Tunicamycin B, aka Tunicamycin VII, n=10, mw=831;
  • Tunicamycin C, aka Tunicamycin II, n=8, mw=845;
  • Tunicamycin D, aka Tunicamycin X, n=11, mw=859
Solubility ( literature )
  • Tunicamycin is soluble in DMSO, alkaline water, hot methanol.
  • Practically insoluble in acetone, ethyl acetate.
  • Unstable in acidic solutions
Compound Classification
  • nucleoside antibiotic
  • antiviral
  • inhibitor of glucosylation of proteins
  • tunicamycin causes cell cycle arrest in G1 phase
  • Tunicamycin has anti-angiogenesis properties.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Tunicamycins inhibit protein glycosylation. They arrest cell cycle in late G1As Tunicamycin affects cell membrane permeability, it was shown to increase production of antibiotics, such as streptomycin PRODUCT USE A tool to study glycoprotein synthesis in a wide variety of biological systems. Family of nucleoside antibiotics produced by Streptomyces lysosuperificus. Tunicamycin interferes with glycoprotein synthesis in yeast and mammalian systems and enhances antiviral and anticellular activity of interferon. Possesses cell - surface altering activity. Inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP -N- acetylglucosamine to dolichol monophosphate and thereby blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi and viruses.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
Deleted CAS Registry Numbers
Value
11118-26-6
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Protein kinase related
Anti Bacterial
Anti Viral
Research field: Signal Transduction
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Trichostatin A

Trichostatin A
Molecular Formula
C17H22N2O3
M.W.
302.37
CAS number
58880-19-6
MSDS
Source
Streptomyces platensis
Fermentek product Code
TRA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
138°C-150°C
Solubility test
Clear colorless solution at 5mg/ml Methanol; Clear yellow solution at 20mg/ml DMSO
Names and identifiers

Synonyms:

  • 2,​4-​Heptadienamide, 7-​[4-​(dimethylamino)​phenyl]​-​N-​hydroxy-​4,​6-​dimethyl-​7-​oxo-​, (2E,​4E,​6R)​-
  • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • TSA
  • (R)-(+)-Trichostatin A

 

 

EU number
611-758-2
Description

Trichostatin A is an antifungal antibiotic.

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC)

InChl Key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Canonical SMILES
CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Isomeric SMILES
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Solubility ( literature )

DMSO, Ethanol

Compound Classification

HDAC inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Signal to sort
T
Trichostatin_A.gif
Trichostatin_A.gif

Thiostrepton

Thiostrepton
Molecular Formula
C72H85N19O18S5
M.W.
1 664.89
CAS number
1393-48-2
MSDS
Source
Streptomyces laurentii
Fermentek product Code
TIS-001
Brand/grade
For research
Appearance
White to off-white powder
slightly yellowish cast may be observed on the solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
>210°C (decomposition, not melting.)
Solubility test
Clear colorless solution at 5mg/ml DMSO or Chloroform
Names and identifiers

Synonyms:  Alaninamide, Bryamycin , Thiactin
RTECS      :   XN6300100

EU number
215-734-9
Description

Thiostrepton is a broad spectrum polypeptide antibiotic which targets a wide range of gram positive and gram negative bacteria.

InChl Key
NSFFHOGKXHRQEW-DVRIZHICSA-N
Canonical SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)C(=CC)NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Isomeric SMILES
CCC(C)C1C(=O)NC(C(=O)NC(=C)C(=O)NC(C(=O)NC23CCC(=NC2C4=CSC(=N4)C(C(OC(=O)C5=NC6=C(C=CC(C6O)N1)C(=C5)C(C)O)C)NC(=O)C7=CSC(=N7)C(NC(=O)C8CSC(=N8)/C(=C\C)/NC(=O)C(NC(=O)C9=CSC3=N9)C(C)O)C(C)(C(C)O)O)C1=NC(=CS1)C(=O)NC(=C)C(=O)NC(=C)C(=O)N)C)C
Solubility ( literature )

Thiostrepton is soluble in chloroform, dichloromethane, dioxane, pyridine, glacial acetic acid, DMF. Practically insoluble in water, the lower alcohols, nonpolar organic solvents, diluted aqeous acids or bases. It may be dissolved by methanolic acid or base, but with decomposition. Working solution of 1% in DMSO is unstable and should be freshly prepared and protected from light.

Compound Classification

Polypeptide antibiotic
Antimicrobial

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Thiostrepton is used as a reagent for both positive and negative selection of genes involved in nucleotide metabolism. Thiostrepton is highly active against gram-positive bacteria. In its crude form, Thiostrepton is used in veterinary medicine, in mastitis caused by gram-negative organisms and in dermatologic disorders. inhibits bacterial protein synthesis. Inhibits mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery and the activity of initiation factor 2 (IF-2).

As an antitumoragent Thiostrepton induces cell cycle arrest and apoptosis in breast cancer cells via downregulation of FOXM1 expression. Thiostrepton is a FoxM1 specific inhibitor.

Disclaimer
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: Not Dangerous Goods; Not Regulated
Transport safety: not regulated.
Available since
Title
Change notif 23-Jule-2018
Value
Updated storage condition
Title
update 22-Jan-2019
Value
minor update, shipment conditions
Title
toxicity by RTECS
Value
LD50 oral mouse >1 gram/kg
Fermentek Product Category
Antibiotics
Research field: Cancer
Protein synthesis inhibitors
Anti Bacterial
Cancer Related Compounds
Research field: Signal Transduction
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Thiostrepton.gif
Thiostrepton.gif

Thiolutin

Thiolutin
Molecular Formula
C8H8N2O2S2
M.W.
228.29
CAS number
87-11-6
Source
Streptomyces luteosporeus
Fermentek product Code
THL-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear yellow solution at 1mg/ml DMSO
Names and identifiers

RTECS JP1355000

Farcinicin,

Propiopyvothine,

Acetopyrrothine

Description

Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.

InChl Key
MHMRAFONCSQAIA-UHFFFAOYSA-N
Canonical SMILES
CC(=O)NC1=C2C(=CSS2)N(C1=O)C
Solubility ( literature )

Thiolutin is soluble in Dichloromethane or Methanol, DMSO (0.5%)Water solubility: 0.2 gram /Liter

Compound Classification

dithiolopyrrolonePyrrolidinone antibioticRNA polymeraseinhibitorangiogenesis inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications

Inhibitor of DNA-primed RNA polimerase and DNA polimerase. Apoptosis inducer. Antineoplastic drug

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Antibiotics
Angiogenesis related
Signal to sort
T

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Price
$1.00
Thiolutin.gif
Thiolutin.gif

Tentoxin

Tentoxin
Molecular Formula
C22H30N4O4
M.W.
414.50
CAS number
28540-82-1
Source
Alternaria alternata
Fermentek product Code
TEN-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
171°C-180°C
Solubility test
Clear colorless solution at 10mg/ml DMSO or Methanol
Names and identifiers

UPAC Name: (3S,6S,12Z)-12-benzylidene-1,6,7-trimethyl-3-(2-methylpropyl)-1,4,7,10-tetrazacyclododecane-2,5,8,11-tetrone

Description

Cyclic peptide from fungus Alternaria

InChl Key
SIIRBDOFKDACOK-LFXZBHHUSA-N
Canonical SMILES
CC1C(=O)NC(C(=O)N(C(=CC2=CC=CC=C2)C(=O)NCC(=O)N1C)C)CC(C)C
Isomeric SMILES
C[C@H]1C(=O)N[C@H](C(=O)N(/C(=C\C2=CC=CC=C2)/C(=O)NCC(=O)N1C)C)CC(C)C
Solubility ( literature )

Tentoxin is soluble in Ethanol (10 mg/ml), with heat as needed;

soluble in Water, Dichloromethane, DMSO

Compound Classification

Cyclic peptide chloroplast ATP synthase  inhibitor

Storage, handling
Refrigerate upon arrival, at +2°C to +8°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Tentoxin was used to eliminate polyphenol oxidase (PPO) activity from seedlings of higher plants.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Mycotoxins
Alternaria toxins
Antibiotics
Cytotoxic agents
Signal to sort
T

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Tentoxin.gif
Tentoxin.gif

Streptozotocin

Streptozotocin
Molecular Formula
C8H15N3O7
M.W.
265.22
CAS number
18883-66-4
Source
Streptomyces sp.
Fermentek product Code
STZ-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
120°C-125°C
Solubility test
Clear colorless solution at 50mg/ml Water, Clear colorless solution at 10mg/ml Ethanol
Names and identifiers

Streptozocin, Streptozotocin, ZanosarD-Glucopyranose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-

 

RTECS: LZ5775000

EU number
242-646-8
Description

Streptozotocin is a natural glucosamine nitrosourea antibiotic.

InChl Key
ZSJLQEPLLKMAKR-UHFFFAOYSA-N
Canonical SMILES
CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
Solubility ( literature )

Water soluble 5g/L at 25°C

Compound Classification

glucosamine nitrosourea antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Streptozocin is used to induce Type 1 diabetes for medical research.Streptozotocin is used in medicine since 1982 as a drug against certain cancers of the Langerhans Islets. It is cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS Registry Numbers
Value
11006-80-7 37793-00-3 132769-73-4
Fermentek Product Category
Antibiotics
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Streptozotocin.gif
Streptozotocin.gif

Staurosporine

Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Anti Fungal
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
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Staurosporine.gif
Staurosporine.gif

Sinefungin

Sinefungin
Molecular Formula
C15H23N7O5
M.W.
381.39
CAS number
58944-73-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
SN
Brand/grade
For research
Appearance
White to yellow powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥96% ; refer to CoA for more data
Solubility test
Clear colorless solution at 20mg/ml of water
Names and identifiers

Synonym:

RTECS: HE3140000

UPAC Name: (2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid

 

 
EU number
637-385-5
Description

Natural antibiotic containing adenine, sugar hydroxyl and amino groups; exhibiting Antifungal ,Antimalarial and Antiprotozoal properties.

InChl Key
LMXOHSDXUQEUSF-YECHIGJVSA-N
Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)CC(CCC(C(=O)O)N)N)O)O
Isomeric SMILES
C1=NC2=C(C(=N1)N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)C[C@H](CC[C@@H](C(=O)O)N)N)O)O
Solubility ( literature )

Good water solubility. Soluble in ethanol, methanol, DMF or DMSO (lit.)

Compound Classification

Chemical class:

  • Adenosine analog
  • Nucleoside antibiotic

Biological activity:

  • Antifungal 
  • Antimalarial
  • Antiprotozoal

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Applications

Sinefungin derivatives as inhibitors and structure probes of protein lysine methyltransferase SETD2 Antifungal Antimalarials Antiprotozoal

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS oral mouse LD50
Value
1 gram/kg
Fermentek Product Category
Antibiotics
Anti Protozoal
Anti Bacterial
Anti Viral
Research field: Signal Transduction
Signal to sort
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Sinefungin.gif
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Rapamycin

Rapamycin
Molecular Formula
C51H79NO13
M.W.
914.17
CAS number
53123-88-9
Source
Streptomyces hygroscopicus subsp hygroscopicus
Fermentek product Code
RAP-001
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
170-185°C
Solubility test
Clear colorless solution at 200mg/ml DMSO
Names and identifiers

Synonyms: RAPA, Rapamune, Sirolimus, RPM, Antibiotic AY 22989

RTECS: VE6250000

EU number
610-965-5
Description

Rapamycin (Sirolimus) is a macrolide compound that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus (Rapamycin) is a potent immunosuppressant. Sirolimus (Rapamycin) possesses both antifungal and antineoplastic properties.

InChl Key
QFJCIRLUMZQUOT-HPLJOQBZSA-N
Canonical SMILES
CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC
Isomeric SMILES
C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC
Solubility ( literature )

Methanol, DMSO

Compound Classification

macrolide immunosuppressor

Storage, handling
-20°C. Protect from light and moisture. Hygroscopic.
Retest time
3 Years
Applications

Research applications: Rapamycin Sirolimus inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways. Rapamycin Sirolimus inhibits T-lymphocyte activation / proliferation occuring in response to antigenic and cytokine (Interleukin IL-2, IL-4, and IL-15) stimulation by a mechanism that is distinct from that of other immunosuppressing agents. Sirolimus also inhibits antibody production.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Anti Fungal
Anti Bacterial
Immunomodulators
Signal to sort
R

Quote for

Price
$1.00
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