Destruxin B
Details
Specifications
Chemical identification
natural product
Further Information
chemical:
Natural cyclic depsipeptide
Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.
natural product
chemical:
Natural cyclic depsipeptide
Synonyms:
Chemical names:
IUPAC:
(3S,7R,11E)-7,14,16-Trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one
RTECS# DM2560000
Alpha-Zearalenol is a synthetic derivative of the macrolactone mycotoxin zearalenone, which is also manufactured by Fermentek by the method of fungal fermentation.. Alpha-Zearalenol is estrogenically active and demonstrates induction of premature uterine growth, increase of nuclear estrogen receptor levels, and a five fold increase of ornithine decarboxylase level (ODC). The increase of ODC level was 20-fold more pronounced with Alpha-Zearalenol than zearalenone, and Alpha-Zearalenol demonstrated three times more potent estrogenic activity than zearalenone.
Synonyms:
Chemical names:
IUPAC:
(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trion e
RTECS#:
Antibiotic agent.
Phytotoxin. Cytochalasin analog
Soluble in DMSO , Ethanol, Methanol
Chemical classification:
Bioactivity classiification:
Synonyms:
(S)-ar-Turmerone
IUPAC Name:
(6S)-2-Methyl-6-(4-methylphenyl)-2-hepten-4-one
Disambiguation:
CAS [532-65-0] means S-ar-Turmerone, while CAS [82508-15-4] belongs to a closely related compound TURMERON, which has two hydrogenes more.
Disambiguation:
Turmerin, an oligo-peptide, from Curcuma longa roots, not to be mistaken for Turmerone, a small molecule of the same source
REACH No. :
A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.
Natural antibiotic of herbal origin, known as potent anti-venom against snake bites; Reported to enhance stem-cells proliferation; Reported as a factor in the regeneration of neural cells and brain damage. Reported to have anti-inflammatory properties.
(S)-ar-Turmerone is an anti-tumor and immune activating agent, which maintains a cytotoxic effect in cancer cells. Also, an antimicrobial agent.
Hexane, Petrol ether, Ethanol, Methanol
Sesquiterpene type natural antibiotic.
Known as potent anti-venom against snake bites; Reported to enhance stem-cells proliferation; Reported as a factor in the regeneration of neural cells and brain damage. Reported to have anti-inflammatory properties.
IUPAC/Chemical name: (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one
Synonyms
KT5555 is a multi targeted tyrosine kinase inhibitor.
Chemical classification
Bioactivity classification
It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).
Synonyms
RTECS: UQ4730500
HSDB 7246
Roquefortine C is a mycotoxin produced by various fungi, particularly species from the Penicillium genus. It was first isolated from a strain of Penicillium roqueforti, a species commercially used to make Roquefort, Danish Blue, Stilton and Gorgonzola cheeses.
Soluble in 100% ethanol, methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (poor).
IUPAC:
(2S)-4-({(1S,2R,4aS,6R,8aR)-1,6-Dimethyl-2-[(1E)-1-propen-1-yl]-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl}carbonyl)-5-hydroxy-2-(hydroxymethyl)-1-methyl-1,2-dihydro-3H-pyrrol-3-one
RTECS KD7986000
Antibiotic from Fusarium equiseti; derivative of N-methyl-2,4-pyrollidone
Equisetin is reported to be soluble in DMF or DMSO, moderately soluble in methanol or ethanol and poorly soluble in water.
Equisetin solubility as reported in an original patent,
Elemental analysis: C, 70.95; H, 8.39; N, 3.14;
Chemical classification:
Tetramic acid class antibiotic.
Classification by Bioactivity:
HIV-integrase inhibitor
Equisetin inhibits some ATPases, and affects several energy related mitochondrial enzymes.
Equisetin was also shown to inhibit (in-vitro) HIV-1 integrase.
Mixed Calcium-Magnesium salt of A23187 (Calcimycin) is prepared chemically from A23187 (Calcimycin).
Used in cell activation experiments when calcium dose-response data are not required.
Cyclic polypeptide antibiotic Virginiamycin S1 is a major component of virginiamycin complex, which is used in veterynary medicine to treat Gram-positive infections, and as a growth promoter in young swine and cattle.
Virginiamycin is originated in Streptomyces virginiae, but also other strains of streptomycettes. Virginiamycin S1 is a cyclic polypeptide antibiotic, of Streptogramin group B class. Reportedly, it targets the 60S ribosomal protein L37 affecting translation, ribosomal structure. It binds to the 23S rRNA
Virginiamycin S1 is soluble in ethanol, methanol, DMSO, Dichloromethane, DMF, and sparingly, in water .
Cyclic peptide antibiotic, Streptogramin group
Synonyms: Streptogramin A; Mikamycin A; Staphilomycin; Ostreogrycin A; Virginiamycin M1 Pristinamycin IIA;
Virginiamycin M1 is a macrolide antibiotic which interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner.
Activity of Virginiamycin M1 at the ribosome blocks translation and produces a bacteriostatic effect.
With addition of Virginiamycin S1 the two antibiotics produce a synergistic bacteriocidal effect.
Virginiamycin M1 is soluble in ethanol (3-4%) , methanol (3-4%), DMSO, Dichloromethane, DMF, and sparingly, in water.
Cyclic peptide antibiotic, of Streptogramin group