Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

Destruxin B

Destruxin B
Molecular Formula
C30H51N5O7
M.W.
593.76
CAS number
2503-26-6
Source
Metarhizium anisopliae
Fermentek product Code
DSB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-240°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane; Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

Chemical names:

IUPAC:

RTECS# HH1500100

EU number
not on EC
Description

natural product

 

 

InChl Key
GNBHVMBELHWUIF-UHFFFAOYSA-N
Canonical SMILES
CCC(C)C1C(=O)N(C(C(=O)N(C(C(=O)NCCC(=O)OC(C(=O)N2CCCC2C(=O)N1)CC(C)C)C)C)C(C)C)C
Compound Classification

chemical:

Natural cyclic depsipeptide 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since

alpha Zearalenol

alpha Zearalenol
Molecular Formula
C18H24O5
M.W.
320.38
CAS number
36455-72-8
MSDS
Source
Semisynthetic
Fermentek product Code
ZLA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
163°C-170°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Alpha-Zearalenol;
  • Trans-Zearalenol,
  • α-Zearalenol; 
  • a-Zearalenol

Chemical names:

  • Alpha-Zearalenol;

IUPAC:

(3S,7R,11E)-7,14,16-Trihydroxy-3-methyl-3,4,5,6,7,8,9,10-octahydro-1H-2-benzoxacyclotetradecin-1-one

RTECS#  DM2560000

EU number
828-728-1
Description

Alpha-Zearalenol is a synthetic derivative of the macrolactone mycotoxin zearalenone, which is also manufactured by Fermentek by the method of fungal fermentation.. Alpha-Zearalenol is estrogenically active and demonstrates induction of premature uterine growth, increase of nuclear estrogen receptor levels, and a five fold increase of ornithine decarboxylase level (ODC). The increase of ODC level was 20-fold more pronounced with Alpha-Zearalenol than zearalenone, and Alpha-Zearalenol demonstrated three times more potent estrogenic activity than zearalenone.

InChl Key
FPQFYIAXQDXNOR-QDKLYSGJSA-N
Canonical SMILES
CC1CCCC(CCCC=CC2=CC(=CC(=C2C(=O)O1)O)O)O
Isomeric SMILES
C[C@H]1CCC[C@@H](CCC/C=C/C2=CC(=CC(=C2C(=O)O1)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
NDG
Signal to sort
A

Chaetoglobosin A

Chaetoglobosin A
Molecular Formula
C32H36N2O5
M.W.
528.64
CAS number
50335-03-0
MSDS
Source
Chaetomium globosum
Fermentek product Code
CHA-001
Brand/grade
For research
Appearance
Yellow to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
165°C-170°C
Solubility test
Clear yellow solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Chaetoglobosins;
  • Chaetoglobosin A;
  • CHAETOGLOBOSIN A;
  • CHAETOGLOBOSIN;
  • CHAETOGLOBOSINB;

Chemical names:

IUPAC:

(1E,4S,5E,7R,9E,11aR,14S,14aR,15S,15aR,16aS,16bR)-7-Hydroxy-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-4,7,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-8,11,12(13H)-trion e

 

RTECS#:

  • HA530500
EU number
not assigned
Chemical name
Chaetoglobosin A
Description

Antibiotic agent.

Phytotoxin. Cytochalasin analog

  • Targets filamentous actin and induces apoptosis.
  • Shows cytotoxic effects against cancer cell lines.
  • Shows antibacterial and nematicidal effects.
  • Induces tissue necrosis in vivo
InChl Key
OUMWCYMRLMEZJH-VOXRAUTJSA-N
Canonical SMILES
CC1CC=CC2C3C(O3)(C(C4C2(C(=O)C=CC(=O)C(C(=C1)C)O)C(=O)NC4CC5=CNC6=CC=CC=C65)C)C
Isomeric SMILES
C[C@H]1[C@H]2[C@@H](NC(=O)[C@@]23[C@@H](/C=C/CC(/C=C(/[C@H](C(=O)/C=C/C3=O)O)\C)C)[C@H]4[C@@]1(O4)C)CC5=CNC6=CC=CC=C65
Solubility ( literature )

Soluble in DMSO , Ethanol, Methanol

Compound Classification

Chemical classification:

  • Indole Alkaloids

Bioactivity classiification:

  • antibacterial
  • cytotoxic
  • Apoptosos inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
toxicity by RTECS
Value
Rodent - rat; Oral LD50 - = >400 mg/kg
Signal to sort
C

Turmerone, (S)-ar-

(S)-ar-Turmerone
Molecular Formula
C15H20O
M.W.
216.30
CAS number
532-65-0
Source
Curcuma longa (extracted from plant)
Fermentek product Code
ART-001
Brand/grade
For research
Appearance
Yellowish oil
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution 10mg in 1ml of Ethanol or Petroleum ether
Names and identifiers

Synonyms:
(S)-ar-Turmerone

IUPAC Name:
(6S)-2-Methyl-6-(4-methylphenyl)-2-hepten-4-one

Disambiguation:  
CAS [532-65-0] means S-ar-Turmerone, while CAS [82508-15-4] belongs to a closely related compound TURMERON, which has two hydrogenes more.

Disambiguation: 
Turmerin, an oligo-peptide,  from Curcuma longa roots, not to be mistaken for Turmerone, a small molecule of the same source

REACH No. :
A registration number is not available for this substance as the substance or its uses are exempted from registration, the annual tonnage does not require a registration or the registration is envisaged for a later registration deadline.

EU number
664-010-2
Chemical name
2-Hepten-4-one, 2-methyl-6-(4-methylphenyl)-, (S)-
Description

Natural antibiotic of herbal origin, known as potent anti-venom against snake bites; Reported to enhance stem-cells proliferation; Reported as a factor in the regeneration of neural cells and brain damage. Reported to have anti-inflammatory properties.

(S)-ar-Turmerone is an anti-tumor and immune activating agent, which maintains a cytotoxic effect in cancer cells. Also, an antimicrobial agent.

InChl Key
NAAJVHHFAXWBOK-ZDUSSCGKSA-N
Canonical SMILES
CC1=CC=C(C=C1)C(C)CC(=O)C=C(C)C
Isomeric SMILES
CC1=CC=C(C=C1)[C@@H](C)CC(=O)C=C(C)C
Solubility ( literature )

Hexane, Petrol ether, Ethanol, Methanol

Compound Classification

Sesquiterpene type natural antibiotic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Known as potent anti-venom against snake bites; Reported to enhance stem-cells proliferation; Reported as a factor in the regeneration of neural cells and brain damage. Reported to have anti-inflammatory properties.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III; Environmentally hazardous;
Fermentek Product Category
Signal to sort
T

KT5555 (Lestaurtinib)

KT5555 (Lestaurtinib)
Molecular Formula
C26H21N3O4
M.W.
439.50
CAS number
111358-88-4
Source
Semisynthetic
Fermentek product Code
LES-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
233°C-243°C
Solubility test
Clear colorless solution at 20mg/ml DMSO
Names and identifiers

IUPAC/Chemical name:  (5S,6S,8R)-6-hydroxy-6-(hydroxymethyl)-5-methyl-7,8,14,15-tetrahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacen-13(6H)-one

Synonyms

  • KT5555
  • Lestaurtinib

 

 

Description

KT5555 is a multi targeted tyrosine kinase inhibitor.

InChl Key
UIARLYUEJFELEN-LROUJFHJSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O
Compound Classification

Chemical classification

  • Indole alcaloids - Carbazoles - Staurosporine-derivates

Bioactivity classification

  • Enzyme inhibitors
  • Proteine kinase inhibitors / Tyrosine kinase inhibitors
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
Retest time
3 Years
Applications

It is used for the treatment of pancreatic cancer and acute myelogenous leukaemia (AML).

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
CN code
Value
29349990
Title
CN code
Value
NO!!!
Title
inert gas storage
Value
after merck, TRC, carbosynth
Signal to sort
K

Roquefortine C

Roquefortine C
Molecular Formula
C22H23N5O2
M.W.
389.50
CAS number
58735-64-1
Source
Penicillium roqueforti
Fermentek product Code
RQC-001
Brand/grade
For research
Appearance
White to slightly yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml Methanol or DMSO
Names and identifiers

Synonyms

  • Roquefortine
  • Roquefortin
  • roquefortine C
  • Rorifone

RTECS: UQ4730500

HSDB 7246

Description

Roquefortine C is a mycotoxin produced by various fungi, particularly species from the Penicillium genus. It was first isolated from a strain of Penicillium roqueforti, a species commercially used to make Roquefort, Danish Blue, Stilton and Gorgonzola cheeses.

InChl Key
SPWSUFUPTSJWNG-CXUHLZMHSA-N
Canonical SMILES
CC(C)(C=C)C12CC3C(=O)NC(=CC4=CN=CN4)C(=O)N3C1NC5=CC=CC=C25
Isomeric SMILES
CC(C)(C=C)C12CC3C(=O)N/C(=C/C4=CN=CN4)/C(=O)N3C1NC5=CC=CC=C25
Solubility ( literature )

Soluble in 100% ethanol, methanol (10 mg/ml), DMSO (10 mg/ml), DMF, and water (poor).

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings
Ingredient type
Fermentek product
Available since
Title
Transport Information
Value
Not Dangerous Goods
Title
toxicity by RTECS
Value
Rodent - mouse ; intraoeritoneal LD50 = 15 mg/kg; no other data
Signal to sort
R

Equisetin

Equisetin
Molecular Formula
C22H31NO4
M.W.
373.49
CAS number
57749-43-6
MSDS
Source
Fusarium equiseti
Fermentek product Code
EQU-001
Brand/grade
For research
Appearance
Light tan to tan or off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml of Methanol or DMSO
Names and identifiers

IUPAC:

(2S)-4-({(1S,2R,4aS,6R,8aR)-1,6-Dimethyl-2-[(1E)-1-propen-1-yl]-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl}carbonyl)-5-hydroxy-2-(hydroxymethyl)-1-methyl-1,2-dihydro-3H-pyrrol-3-one

RTECS KD7986000

EU number
303-396-6
Description

Antibiotic from Fusarium equiseti; derivative of N-methyl-2,4-pyrollidone

InChl Key
QNQBPPQLRODXET-HMHJLHGTSA-N
Canonical SMILES
CC=CC1C=CC2CC(CCC2C1(C)C(=C3C(=O)C(N(C3=O)C)CO)O)C
Isomeric SMILES
C/C=C/[C@@H]1C=C[C@@H]2C[C@@H](CC[C@H]2[C@]1(C)/C(=C\3/C(=O)[C@@H](N(C3=O)C)CO)/O)C
Solubility ( literature )

Equisetin is reported to be soluble in DMF or DMSO, moderately soluble in methanol or ethanol and poorly soluble in water.

Equisetin solubility as reported in an original patent,

  • in acetone of 660 mg./ml.,
  • in ethanol of 330 mg./ml.,
  • in methanol of 220 mg./ml.,
  • in hexane of 0.8 mg./ml.,
  • in water of 0.3 mg./ml.

Elemental analysis: C, 70.95; H, 8.39; N, 3.14;

Compound Classification

Chemical classification:

Tetramic acid class antibiotic.

Classification by Bioactivity:

HIV-integrase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Equisetin inhibits some ATPases, and affects several energy related mitochondrial enzymes.

Equisetin was also shown to inhibit (in-vitro) HIV-1 integrase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Amber-glass vial.
Available since
Title
Transport
Value
Not regulated
Title
Animal rawmat
Value
No
Signal to sort
E

A23187 Ca-Mg

A23187 Ca-Mg
CAS number
This mixture has no CAS number assigned to it.
Source
Semisynthetic
Fermentek product Code
ACM-001
Brand/grade
For research
Appearance
White powder
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
280°C-305°C
Solubility test
Clear colorless solution at 10mg/ml Dichloromethane
Description

Mixed Calcium-Magnesium salt of A23187 (Calcimycin) is prepared chemically from A23187 (Calcimycin).

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend +3 to +8°C storage.
Retest time
3 Years
Applications

Used in cell activation experiments when calcium dose-response data are not required.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient Other
(A23187)2 Mg
Ingredient type
Fermentek product
Ingredient amount
50%
Ingredient Other
(A23187)2 Ca;
Ingredient type
Fermentek product
Ingredient amount
50%
Title
Transport information
Value
Not hazardous for transport
Title
sig
Value
100106
Title
TSE category
Value
S
Title
TSE category
Value
S
Fermentek Product Category
Signal to sort
A

Virginiamycin S1

Virginiamycin S1
Molecular Formula
C43H49N7O10
M.W.
823.89
CAS number
23152-29-6
Source
Streptomyces virginiae
Fermentek product Code
VIS-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
222°C-235°C
Solubility test
Clear colorless solution at 5 mg/ml of Dichloromethane
Names and identifiers
  • Staphylomycin S
  • N-(3-Hydroxypicolinoyl)-L-threonyl-D-alpha-aminobutyryl-L- prolyl-N-methyl-L-phenylalanyl-4-oxo-L-pipecoloyl-L-2- phenylglycine rho-lactone
EU number
245-462-6
Description

Cyclic polypeptide antibiotic Virginiamycin S1 is a major component of virginiamycin complex, which is used in veterynary medicine to treat Gram-positive infections, and as a growth promoter in young swine and cattle. 

Virginiamycin is originated in Streptomyces virginiae, but also other strains of streptomycettes. Virginiamycin S1 is a cyclic polypeptide antibiotic, of Streptogramin group B class. Reportedly, it targets the 60S ribosomal protein L37 affecting translation, ribosomal structure. It binds to the 23S rRNA

InChl Key
FEPMHVLSLDOMQC-CPKGNLGUSA-N
Canonical SMILES
CCC1C(=O)N2CCCC2C(=O)N(C(C(=O)N3CCC(=O)CC3C(=O)NC(C(=O)OC(C(C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C
Isomeric SMILES
CC[C@H]1C(=O)N2CCC[C@@H]2C(=O)N([C@@H](C(=O)N3CCC(=O)C[C@H]3C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(=O)N1)NC(=O)C4=C(C=CC=N4)O)C)C5=CC=CC=C5)CC6=CC=CC=C6)C
Solubility ( literature )

Virginiamycin S1 is soluble in ethanol, methanol, DMSO, Dichloromethane, DMF, and sparingly, in water .

Compound Classification

Cyclic peptide antibiotic, Streptogramin group

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Signal to sort
V

Virginiamycin M1

Virginiamycin M1
Molecular Formula
C28H35N3O7
M.W.
525.59
CAS number
21411-53-0
MSDS
Source
Streptomyces virginiae
Fermentek product Code
VIM-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
165°C-170°C (decompose)
Solubility test
Clear colorless to light yellow solution at 5 mg/ml of Dichloromethane
Names and identifiers

Synonyms:    Streptogramin A; Mikamycin A;  Staphilomycin; Ostreogrycin A; Virginiamycin M1 Pristinamycin IIA;

EU number
244-376-6
Description

Virginiamycin M1 is a macrolide antibiotic which interacts with the bacterial 50S ribosome, inhibiting its function in a reversible manner.
Activity of Virginiamycin M1 at the ribosome blocks translation and produces a bacteriostatic effect.
With addition of Virginiamycin S1 the two antibiotics produce a synergistic bacteriocidal effect.

InChl Key
DAIKHDNSXMZDCU-FQTGFAPKSA-N
Canonical SMILES
CC1C=CC(=O)NCC=CC(=CC(CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)OC1C(C)C)O)C
Isomeric SMILES
C[C@@H]1/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)CC2=NC(=CO2)C(=O)N3CCC=C3C(=O)O[C@@H]1C(C)C)O)/C
Solubility ( literature )

Virginiamycin M1 is soluble in ethanol (3-4%) , methanol (3-4%), DMSO, Dichloromethane, DMF, and sparingly, in water.

Compound Classification

Cyclic peptide antibiotic, of Streptogramin group

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Signal to sort
V