Details
Specifications
Chemical identification
IUPAC:
(2S)-4-({(1S,2R,4aS,6R,8aR)-1,6-Dimethyl-2-[(1E)-1-propen-1-yl]-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl}carbonyl)-5-hydroxy-2-(hydroxymethyl)-1-methyl-1,2-dihydro-3H-pyrrol-3-one
RTECS KD7986000
Antibiotic from Fusarium equiseti; derivative of N-methyl-2,4-pyrollidone
Further Information
Equisetin is reported to be soluble in DMF or DMSO, moderately soluble in methanol or ethanol and poorly soluble in water.
Equisetin solubility as reported in an original patent,
- in acetone of 660 mg./ml.,
- in ethanol of 330 mg./ml.,
- in methanol of 220 mg./ml.,
- in hexane of 0.8 mg./ml.,
- in water of 0.3 mg./ml.
Elemental analysis: C, 70.95; H, 8.39; N, 3.14;
Chemical classification:
Tetramic acid class antibiotic.
Classification by Bioactivity:
HIV-integrase inhibitor
Equisetin inhibits some ATPases, and affects several energy related mitochondrial enzymes.
Equisetin was also shown to inhibit (in-vitro) HIV-1 integrase.
Composition
Supply related information
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