Valinomycin

Molecular Formula:

C54H90N6O18

CAS number:

2001-95-8

EU number:

217-896-6

Fermentek product code:

VAL

Source:

Streptomyces fulvissimus

Brand/grade:

For research

Specifications

Appearance:

White powder

Purity by HPLC:

≥96% ; by ELSD, refer to CoA for more data

Purity By TLC:

≥98% ; refer to CoA for more data

Melting point:

186°C-190°C

Solubility test:

Clear colorless solution at 50mg/ml Dicloromethane or DMSO

Chemical identification

Names and identifiers:

Synonyms: Potassium ionophore I

HSDB: 6423

EINECS: 217-896-6

RTECS: YV9468000

Description:

Valinomycin is a cyclododecadepsipeptide ionophore antibiotic produced by Streptomyces fulvissimus and chemically related to the enniatins.

Molecular weight:

1 111.32

InChl Key:

FCFNRCROJUBPLU-UHFFFAOYSA-N

Canonical SMILES:

CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C

Isomeric SMILES:

C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C

Further Information

Compound Classification:

cyclic oligopeptide Ionophore

Storage, handling:

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Other vendors may recommend higher temperatures for storage.

Applications:

Valinomycin is a potassium ionophore, research reagent in the field of cell membrane biophysics. It possesses antifungal, antibacterial and antiviral properties.

As an antiviral agent, Valinomycin is considered for the treatment of Coronavirus diseases.
As an antibacterial agent, it is considered to be used in bio-diesel manufacturing.
As a potassium ionophore, valinomycin acts as a nonmetallic agent in potassium selective electrodes.
Valinomycin acts as an apoptosis inducer

Disclaimer:

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type:

Fermentek product

Publications

Zhang, Dong; Ma, Zhi; Chen, Hanchi; Lu, Yuele; Chen, Xiaolong (October 2020)
Valinomycin as a potential antiviral agent against coronaviruses: A review
Biomedical Journal Volume 43, Issue 5, October 2020, Pages 414-423
https://www.sciencedirect.com/science/article/pii/S2319417020301402
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Joko T. Wibowo, Matthias Y. Kellermann, Matthias Köck, Masteria Y. Putra, Tutik Murniasih, Kathrin I. Mohr, Joachim Wink, Dimas F. Praditya Eike Steinmann, Peter J. Schupp
Anti-Infective and Antiviral Activity of Valinomycin and Its Analogues from a Sea Cucumber-Associated Bacterium, Streptomyces sp
Mar Drugs. 2021 Feb; 19(2): 81
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912928/

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Sayed S. Daoud; R. L. Juliano
Reduced Toxicity and Enhanced Antitumor Effects in Mice of the Ionophoric Drug Valinomycin When Incorporated in Liposomes
Cancer Res (1986) 46 (11): 5518–5523.
https://aacrjournals.org/cancerres/article/46/11/5518/490254/Reduced-Toxicity-and-Enhanced-Antitumor-Effects-in

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Zachary J. Sandler, Mason R. Firpo, Oreoluwa S. Omoba, Michelle N. Vu, Vineet D. Menachery, Bryan C. Mounce
Novel Ionophores Active against La Crosse Virus Identified through Rapid Antiviral Screening
ASM Journals. Antimicrobial Agents and Chemotherapy. Vol. 64, No. 6
https://journals.asm.org/doi/10.1128/aac.00086-20

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Special Info

Available since:

2003

Other Fields

Title:

Transport information

Value:

Hazard. Pg I

Title:

Deleted CAS numbers

Value:

134-16-7; 11005-80-4; 32398-05-3

Title:

Inventory Status canada

Value:

On NDSL Canada Gazette, Part I, January 31, 1998

Title:

regulatory india

Value:

List of Hazardous Chemicals, 2000.

Title:

regulatory USA

Value:

40 CFR Part 302 ; 40 CFR Part 355