Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

Meleagrin

Meleagrin
Molecular Formula
C23H23N5O4
M.W.
433.46
CAS number
71751-77-4
Source
Penicillium chrysogenum
Fermentek product Code
MEG-001
Brand/grade
For research
Appearance
Light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear light yellow solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: 6-O-Methyloxaline

Chemical names:

IUPAC: (3E,7aS,12aR)-6-hydroxy-3-(1H-imidazol-4-ylmethylidene)-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione

RTECS#

Chemical name
Meleagrin
Description

Meleagrin, a fungal alcaloide antibiotic, posesses antitumor and antibiotic activity. Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase.

Meleagrin, CAS 71751-77-4, the fungal alcaloide, should not be confused with the low molecular weight peptide cas 121272-63-7, which is isolated from turkey also called meleagrin.

 

InChl Key
JTJJJLSLKZFEPJ-YVLHZVERSA-N
Canonical SMILES
CC(C)(C=C)C12C=C(C(=O)N3C1(NC(=O)C3=CC4=CN=CN4)N(C5=CC=CC=C25)OC)O
Isomeric SMILES
CC(C)(C=C)[C@]12C=C(C(=O)N\3[C@@]1(NC(=O)/C3=C\C4=CN=CN4)N(C5=CC=CC=C25)OC)O
Solubility ( literature )

Ethanol, methanol, DMF or DMSO. Poor water solubility

Compound Classification

Alcaloide antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Inhibitor of:  Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Lot 001 special tests
Value
NMR: complies with structure
Title
Transport information
Value
Not dangerous goods.
Title
Enzyme affected
Value
A Fabl inhibitor
Title
Research fields
Value
Immunology, Inflamation,
Title
madcow category
Value
V=veg fermentation
Signal to sort
M

Tropodithietic acid (TDA)

Tropodithietic acid (TDA)
Molecular Formula
C8H4O3S2
M.W.
212.25
CAS number
750590-18-2
Source
Phaeobacter gallaeciensis
Fermentek product Code
TDA-001
Brand/grade
For research
Appearance
Orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
207°C-213°C
Solubility test
Clear yellow solution at 1 mg/ml of Dichloromethane.
Clear yellow solution at 0.5 mg/ml of Methanol
Names and identifiers

Synonyms:             TDA

Chemical names:   Tropodithietic acid

IUPAC:                    3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid

RTECS#                   Not available

 

EU number
806-061-7
Chemical name
Tropodithietic acid
Description

A sulphur containing antibiotic from marine bacteria, responsible for the probiotic proprties of some of these.  Tropodithietic acid It is active against Gram-positive and Gram-negative bacteria, some phytopathogens and mycoplasma. It also has anti-plasmodium activity.

InChl Key
BLFCMITWMARUSM-UHFFFAOYSA-N
Canonical SMILES
C1=CC(=O)C(=C2C(=C1)SS2)C(=O)O
Solubility ( literature )

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

Warning or harmful

  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    • Respiratory tract irritation
    • Narcotic effects
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
source
Value
Phaeobacter gallaeciensis
Signal to sort
T

Concanamycin A (Folimycin)

Concanamycin A (Folimycin)
Molecular Formula
C46H75NO14
M.W.
866.09
CAS number
80890-47-7
Source
Streptomyces sp.
Fermentek product Code
CON-001
Brand/grade
For research
Appearance
White crystals
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Concamycin A
  • Folimycin
  • Concanamycin

Comment: Many other suppliers, as well as PUBCHEM, CHEMSPIDER and publications, consider Folimycin and Concanamycin A to be synonyms, while SCIFINDER considers these compounds to be different.

IUPAC: 

3-O-(4-O-Carbamoyl-2,6-dideoxy-β-D-arabino-hexopyranosyl)-2,4-dideoxy-1-C-{4-[(4E,6E,14E,16Z)-11-ethyl-10,12-dihydroxy-3,17-dimethoxy-7,9,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6,14,16-tetraen- 2-yl]-3-hydroxy-2-pentanyl}-4-methyl-5-[(1E)-1-propen-1-yl]-β-D-threo-pentopyranose

RTECS# CB9732000

 

EU number
620-709-4
Chemical name
Concanamycin A
Description

Macrolide type antibiotic, ATPase inhibitor, having antiproliferative, antifungal and antimalarial effects.

InChl Key
DJZCTUVALDDONK-HQMSUKCRSA-N
Canonical SMILES
CCC1C(C(CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C=CC)C)OC3CC(C(C(O3)C)OC(=O)N)O)O)O)OC)C)C)O
Isomeric SMILES
CC[C@H]1[C@H]([C@@H](C/C(=C/C=C/[C@@H]([C@H](OC(=O)/C(=C/C(=C/[C@H]([C@H]1O)C)/C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)OC(=O)N)O)O)O)OC)/C)C)O
Solubility ( literature )

Concanamycin A is reported to be soluble in chloroform, methanol, ethanol, acetone, ethyl acetate, and DMSO.

Concanamycin A is not soluble in water.

 

 

 

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Reportedly, OK to freeze; Frozen stock solutions in DMSO are stable 1 year
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
CN code
Value
--
Title
Depreciated CAS Registry Numbers
Value
66771-59-3
Signal to sort
C

10,11-Dehydrocurvularin

10,11-Dehydrocurvularin
Molecular Formula
C16H18O5
M.W.
290.31
CAS number
21178-57-4
MSDS
Source
Penicillium citrinum
Fermentek product Code
DEH-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-223°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Trans-Dehydrocurvularin
  • Dehydrocurvularin
  • 10,11-dehydrocurvularin
  • alpha,beta-Dehydrocurvularin
  • 1095588-70-7

Comment: There are two CAS Registration numbers, corresponding to the name  Dehydrocurvularin1095588-70-7, 21178-57-4 These numbers are not "synonyms." The represent two stereo isomers.

Chemical names: 10,11-Dehydrocurvularin

IUPAC:  (5S,9E)-13,15-dihydroxy-5-methyl-4-oxabicyclo[10.4.0]hexadeca-1(12),9,13,15-tetraene-3,11-dione                             

RTECS#

Chemical name
10,11-Dehydrocurvularin
Description

10,11-Dehydrocurvularin is an inhibitor of cell division shown to have antimalarial activity, antibacterial proprerties.

 

InChl Key
AVIRMQMUBGNCKS-RWCYGVJQSA-N
Canonical SMILES
CC1CCCC=CC(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Isomeric SMILES
C[C@H]1CCC/C=C/C(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Compound Classification

Natural antibiotic, anti-bacterial, antifungal, phytotoxic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport.
Signal to sort
D

Filipin III

Filipin III
Molecular Formula
C35H58O11
M.W.
654.83
CAS number
480-49-9
Source
Streptomyces filipinensis
Fermentek product Code
FLP-002
Brand/grade
For research
Appearance
White to slight yellow
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Desoxylagosin
  • Filimarisin
  • Filipin

Chemical names:

IUPAC: (17E,19E,21E,23E,25E)-4,6,8,10,12,14,16,27-octahydroxy-3-(1-hydroxyhexyl)-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one

RTECS# RN9800000

EU number
637-175-3
Description

Filipin III, a polyene (pentaene) macrocyclic lactone broad spectrum antifungal antibiotic,  also exhibits antitumor and antiviral activities. It acts by binding cell membrane sterols, disrupting membrane integrity.  Filipin III, the most abundant component of  Filipin complex is offered in pure form.

InChl Key
IMQSIXYSKPIGPD-YQRUMEKGSA-N
Canonical SMILES
CCCCCC(C1C(CC(CC(CC(CC(CC(CC(C(=CC=CC=CC=CC=CC(C(OC1=O)C)O)C)O)O)O)O)O)O)O)O
Isomeric SMILES
CCCCCC(C1C(CC(CC(CC(CC(CC(CC(/C(=C/C=C/C=C/C=C/C=C/C(C(OC1=O)C)O)/C)O)O)O)O)O)O)O)O
Compound Classification

 

Warning! This substance causes serious eye irritation, causes skin irritation and may cause respiratory irritation.

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings
Ingredient type
Fermentek product
Available since

Curvularin

Curvularin
Molecular Formula
C16H20O5
M.W.
292.33
CAS number
10140-70-2
Source
Penicillium citrinum
Fermentek product Code
CUR-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
201°C-208°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

Chemical names: Curvularin;

IUPAC:  (4S)-11,13-Dihydroxy-4-methyl-4,5,6,7,8,9-hexahydro-2H-3-benzoxacyclododecine-2,10(1H)-dione                             

RTECS  n.a.

EU number
806-033-4
Chemical name
Curvularin
Description

Curvularin, an antibiotic from penicillium fungus, when added to cattle feed, may promote growth and increase feed efficiency.

InChl Key
VDUIGYAPSXCJFC-UHFFFAOYSA-N
Canonical SMILES
CC1CCCCCC(=O)C2=C(C=C(C=C2CC(=O)O1)O)O
Solubility ( literature )

Curvularin is reported to be soluble in ethanol, methanol, DMF and DMSO.

Compound Classification

Natural antibiotic, anti-bacterial, antifungal, phytotoxic.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
1401-99-6
Fermentek Product Category
Signal to sort
C

Filipin complex

Filipin complex
Molecular Formula
C35H58O11
M.W.
654.80
CAS number
11078-21-0
Source
Streptomyces filipinensis
Fermentek product Code
FLP-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥95% as complex ; refer to CoA for more data
Solubility test
Clear to hazy yellow solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:   

  • 14-Deoxylagosin
  • Filimirasin
  • Filipin complex
  • Filmirisin

Chemical names:

IUPAC:

RTECS# LK4400000

EU number
631-260-9
Description

A complex of polyene (pentaene) macrocyclic lactones antibiotics obtained from Streptomyces filipinensis. Filipin complex is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities. Filipin complex acts by binding cell membrane sterols, disrupting membrane integrity.inhibits mitochondrial respiration.
In the product of Fermentek, Filipin III is the most abundant component of  the bulk complex (>>70%) of the complex.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Animal rawmat
Value
No
Signal to sort
F

alpha Zearalanol

alpha Zearalanol
Molecular Formula
C18H26O5
M.W.
322.40
CAS number
26538-44-3
MSDS
Source
Semisynthetic
Fermentek product Code
ZAL-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
180°C-185°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:      Zeranol;    α-Zearalanol; 

Chemical names:   

IUPAC: 6-(6,10-Dihydroxyundecyl)-beta-resorcylic acid, mu-lactone;

RTECS#  DM2520000

EU number
247-769-0
Description

Alpha-Zearalanol is a minor analogue of the zearalenone family of mycotoxins.

InChl Key
DWTTZBARDOXEAM-TZMCWYRMSA-N
Canonical SMILES
CC1CCCC(CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Isomeric SMILES
C[C@@H]1CCC[C@@H](CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Compound Classification

Macrolide.

Mycotoxin - Zearalenone group

Fito-estrogen

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Phytoestrogen alpha-zearalanol  improves vascular function  in  ovariectomized  hyperhomocvsteinemic  rats. 

 

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS Registry Numbers
Value
5975-81-5 | 21307-30-2 | 24507-00-4 | 39487-91-7 | 40036-43-9
Signal to sort
A

beta Zearalanol

beta Zearalanol
Molecular Formula
C18H26O5
M.W.
322.40
CAS number
42422-68-4
MSDS
Source
Semisynthetic
Fermentek product Code
ZBL-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
151°C-159°C
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:          

  • estrogen P 1560
  • taleranol

Chemical names:

  • β- Zearalanol

IUPAC:                

  • (7S,11S)-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(14),15,17-trien-13-one

RTECS#  DM2540000

 

EU number
636-982-8
Chemical name
beta Zearalanol
Description

Beta-Zearalanol, also known as taleranol, is a minor analogue of the zearalenone family of resorcinyl macrocyclic lactones, produced by several species of Fusarium. Like the other zearalenones, Beta-zearalanol exhibits estrogenic activity in animals.

 

 
InChl Key
DWTTZBARDOXEAM-JSGCOSHPSA-N
Canonical SMILES
CC1CCCC(CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Isomeric SMILES
C[C@H]1CCC[C@H](CCCCCC2=CC(=CC(=C2C(=O)O1)O)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Title
Transport information
Value
Not hazardous for transport
Title
validations
Value
SCIFINDER formula,structure, CAS validated
Signal to sort
B

Altenuene

Altenuene
Molecular Formula
C15H16O6
M.W.
292.28
CAS number
29752-43-0
MSDS
Source
Alternaria sp.
Fermentek product Code
ALT-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
185°C-190°C
Solubility test
Clear colorless solution at 5mg/ml of Acetone or Methanol
Names and identifiers

Synonyms:

Chemical names:

Systematic name: 6H-Dibenzo(b,d)pyran-6-one, 2,3,4,4a-tetrahydro-2,3,7-trihydroxy-9-methoxy-4a-methyl-, (2-alpha,3-beta,4a-beta)-(+-)-

IUPAC: (2S,3S,4aS)-2,3,7-Trihydroxy-9-methoxy-4a-methyl-2,3,4,4a-tetrahydro-6H-benzo[c]chromen-6-one                              

RTECS#  HP8758000

EU number
814-111-4
Description

Mycotoxin from Alternaria moulds.

InChl Key
MMHTXEATDNFMMY-WBIUFABUSA-N
Canonical SMILES
CC12CC(C(C=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O)O
Isomeric SMILES
C[C@]12C[C@@H]([C@H](C=C1C3=CC(=CC(=C3C(=O)O2)O)OC)O)O
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS Numbers
Value
916665-00-4; 31273-73-1;
Title
CAS comments
Value
Two distinct compounds: 889101-41-1 (-)(-)Altenuene from alternaria and 29752-43-0
Signal to sort
A