Thiolutin is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. It was found to inhibit in vitro RNA synthesis directed by all three yeast RNA polymerases (I, II, and III). Thiolutin is also an inhibitor of mannan and glucan formation in Saccharomyces cerevisiae and used for the analysis of mRNA stability. Studies have shown that thiolutin inhibits adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin and thus suppresses tumor cell-induced angiogenesis in vivo.
Thiolutin is soluble in Dichloromethane or Methanol, DMSO (0.5%)Water solubility: 0.2 gram /Liter
dithiolopyrrolonePyrrolidinone antibioticRNA polymeraseinhibitorangiogenesis inhibitor
Inhibitor of DNA-primed RNA polimerase and DNA polimerase. Apoptosis inducer. Antineoplastic drug