Mycotoxins are defined as naturally occurring substances produced by filamentous fungi (moulds) that arouse toxic response when introduced in low amounts to animals through a natural pathway. These fungi are referred to as “toxigenic” fungi. They grow naturally as a form of contaminants on some food crops, majorly cereals, nuts and fruit. Conventionally, toxigenic fungi which contaminate crops have been classified into two groups: “field” and “storage” fungi. Field fungi (such as Cladosporium, Fusarium and Alternaria spp.) get to plants during the developmental stage of the plant; while storage fungi (e.g., Aspergillus and Penicillium spp.) proliferate during the storage period.

Mycotoxins, which are low weight secondary metabolites, produce harmful substances called Mycotoxicoses in animals which invariably impact public health. The toxicity effects of Mycotoxins could be acute or chronic, or both. The most toxic of these, is Aflatoxins. Aflatoxins B1, B2, G1 and G2 are a critical concern. A low-level exposure to Aflatoxin for a long term has been associated with different liver diseases such as cancer, jaundice, cirrhosis and hepatis. Also, they are genotoxic (DNA-damaging) carcinogenic and immunosuppressants. Ochratoxin A is another type of mycotoxin that is teratogenic (reproductive), immunosuppressant, and had been proved to have connection with kidney diseases. Other toxigenic fungi are associated with protein synthesis inhibition, genotoxic, and immune dysfunction.

Fermentek is a global leader in the production of high-standard reference material for Mycotoxins for food safety analysis and research. The company offers more than 60 types of Mycotoxins manufactured from various different microorganisms, divided into nine known Mycotoxin families. These products are formulated into a powdered form or standard solutions with high purity characterized by their melting points, TLC & HPLC. 

mycotoxins

T2 toxin Tetraol

T2 toxin Tetraol
Molecular Formula
C15H22O6
M.W.
298.33
CAS number
34114-99-3
MSDS
Source
Semisynthetic
Fermentek product Code
TET-001
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
125°C- 135°C
Solubility test
Clear colorless solution at 10 mg/ml Dichloromethane
Names and identifiers

Synonyms

  • 3-alpha,4-beta,8-alpha,15-Tetrahydroxy-12,13-epoxytrichothec-9-ene
  • Toxin T4
  • T-2 tetraol
  • T-2 toxin tetraol

RTECS: YC9980000

EU number
621-631-3
Description

T2-tetraol is a type-A trichothecene mycotoxin that occurs in nature

InChl Key
ZAXZBJSXSOISTF-ZSTBYQRGSA-N
Canonical SMILES
CC1=CC2C(CC1O)(C3(C(C(C(C34CO4)O2)O)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@](C[C@@H]1O)([C@]3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)CO
Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Compound Classification

chemical class: trichothecene type A mycotoxin

Storage, handling
-20°C. Protect from light.Comment: trichocethenes are thermostable compounds and are not destroyed in boiling.
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I ; Inh.Toxicity confirmed
Fermentek Product Category
Signal to sort
T

T2 Toxin

Molecular Formula
C24H34O9
M.W.
466.52
CAS number
21259-20-1
MSDS
Source
Fusarium tricinctum
Fermentek product Code
T2T-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
150°C-154°C
Solubility test
Clear colorless solution at 5mg/ml Dichloromethane
Names and identifiers

Synonyms

  • Fusariotoxin T2
  • T2 TOXIN
  • MYCOTOXIN T2
  • 8-(3-Methylbutyryloxy)-diacetoxyscirpenol
  • Trichothec-9-ene-3.alpha.,8.alpha.,15-tetrol, 12,13-epoxy-, 4,15-diacetate 8-isovalerate

RTECS: YD0100000

 

EU number
244-297-7
Chemical name
T2 TOXIN
Description

T2 Toxin: A trichothecene group mycotoxin, of the most important Fusarium toxins.

InChl Key
BXFOFFBJRFZBQZ-QYWOHJEZSA-N
Canonical SMILES
CC1=CC2C(CC1OC(=O)CC(C)C)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](C[C@@H]1OC(=O)CC(C)C)([C@]3([C@@H]([C@H]([C@H]([C@@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Ethyl Acetate. Slightly soluble in petroleum ether; very slightly soluble in water.

Compound Classification

Trichothecene Mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

T-2 toxin has been reported to be used to increase blood-brain barrier permeability in rats.

T-2 Toxin induces DNA damage and cell death on prolonged administration.

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Signal to sort
T

Sterigmatocystin

Sterigmatocystin
Molecular Formula
C18H12O6
M.W.
324.28
CAS number
10048-13-2
MSDS
Source
Aspergillus versicolor
Fermentek product Code
STR-001
Brand/grade
For research
Appearance
Yellow to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
240°C-246°C
Solubility test
Clear colorless solution at 5mg/ml of Acetone; Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Systematic name:    8-Hydroxy-6-methoxy-3a,12c-dihydro-7H-furo[3',2':4,5]furo[2,3-c]xanthen-7-one

RTECS:                     LV1750000

RTECS#:                 LV1750000

HSDB:                      HSDB3540

EU number
233-158-6
Description

Sterigmatocystin is a mycotoxin, inhibitor of DNA synthesis, closely related to Aflatoxins.

InChl Key
UTSVPXMQSFGQTM-DCXZOGHSSA-N
Canonical SMILES
COC1=C2C(=C3C4C=COC4OC3=C1)OC5=C(C2=O)C(=CC=C5)O
Isomeric SMILES
COC1=C2C(=C3[C@@H]4C=CO[C@@H]4OC3=C1)OC5=C(C2=O)C(=CC=C5)O
Solubility ( literature )

DMSO, Methanol, Ethanol, Acetone.

Compound Classification

Chemical classification:

Xanthones
    Sterigmatocystin

Bioactivity classification:

Toxin affecting liver and kidneys
Sterigmatocystin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Not for veterinary use!
Warnings

Health-Hazard

  • Respiratory sensitization, category 1
  • Germ cell mutagenicity, categories 1A, 1B, 2
  • Carcinogenicity, categories 1A, 1B, 2
  • Reproductive toxicity, categories 1A, 1B, 2
  • Specific target organ toxicity following single exposure, categories 1, 2
  • Specific target organ toxicity following repeated exposure, categories 1, 2
  • Aspiration hazard, categories 1, 2

Warning or harmful

  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    • Respiratory tract irritation
    • Narcotic effects
Ingredient type
Fermentek product
Transport safety: class 6.1 PG III
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS numbers
Value
105521-97-9
Fermentek Product Category
Signal to sort
S

Penitrem A

Penitrem A
Molecular Formula
C37H44ClNO6
M.W.
634.20
CAS number
12627-35-9
MSDS
Source
Penicillium palitans
Fermentek product Code
PEA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥96% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
224°C-231°C with decomposition
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: Tremortin A

RTECS:       RY7535000

 
Description

Penitrem A, also known as Tremortin-A , is a tremorgenic toxin, potent inhibitor of smooth muscle high-conductance calcium-activated potassium channels.

InChl Key
JDUWHZOLEDOQSR-UHFFFAOYSA-N
Canonical SMILES
CC(=C)C1C(C2C3(O2)C(O1)CCC4(C3(CCC5C4(C6=C7C5OC(C8CC9C8(C1=C7C(=CC(=C1CC9=C)Cl)N6)O)(C)C)C)O)C)O
Solubility ( literature )

Acetone, Methanol, and DMSO.

Compound Classification

Chemical classification:

  • indole alkaloid

Classification by Biological activities

  • Neurotoxin
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Signal to sort
P

Penicillic acid

Penicillic acid
Molecular Formula
C8H10O4
M.W.
170.16
CAS number
90-65-3
Source
Penicillium Cyclopium
Fermentek product Code
PEN-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ ml Dichloromethane
Names and identifiers

Synonyms

  • 3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid

HSDB 3523

RTECS  MM2625000

EU number
202-008-1
Chemical name
3-Methoxy-5-methyl-4-oxo-2,5-hexadienoic acid
Description

Penicillic acid is a polyketide mycotoxin which induces single and double strand DNA breaks. It inhibits GDP-mannose dehydrogenase. It inhibits also muscle aldose dehydrogenase, lactate dhydrogenase and alcohol dehydrogenase.

InChl Key
VOUGEZYPVGAPBB-XQRVVYSFSA-N
Canonical SMILES
CC(=C)C(=O)C(=CC(=O)O)OC
Isomeric SMILES
CC(=C)C(=O)/C(=C/C(=O)O)/OC
Solubility ( literature )

Water, Ethanol, Dichloromethane.

Compound Classification
  • Lactone Mycotoxin
  • Hexanoic Acid
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since

Paxilline

Paxilline
Molecular Formula
C27H33NO4
M.W.
435.56
CAS number
57186-25-1
MSDS
Source
Penicillium paxilli
Fermentek product Code
PAX-001
Brand/grade
For research
Appearance
White crystalline powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 100mg/ml DMSO; Clear colorless solution at 5mg/ml Acetone
Names and identifiers

*** Disambiguation: ***
Paxilline, a mycotoxin of penicillium origin, should not be confused with
Paxillin, a signal transducing adaptor protein involved in cell migration (MESH).

IUPAC name
(2R,​4bS,​6aS,​12bS,​12cR,​14aS)-​4b-​hydroxy-​2-​(1-​hydroxy-​1-​methylethyl)-​12b,​12c-​dimethyl-​5,​6,​6a,​7,​12,​12b,​12c,​13,​14,​14a-​decahydro-​2H-​chromeno​[5',6':​6,7]​indeno​[1,2-​b]​indol-​3(4bH)-​one

RTECSDJ2830000

EU number
637-206-0
Description

Paxilline: a selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels

InChl Key
ACNHBCIZLNNLRS-UBGQALKQSA-N
Canonical SMILES
CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O
Isomeric SMILES
C[C@]12CC[C@H]3C(=CC(=O)[C@H](O3)C(C)(C)O)[C@@]1(CC[C@@H]4[C@@]2(C5=C(C4)C6=CC=CC=C6N5)C)O
Solubility ( literature )

Acetone, Methanol, and DMSO.

Compound Classification
  • tremorgen mycotoxin
  • Potassium chanells blocker
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Potassium channels blocker

Disclaimer
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Signal to sort
P

Patulin

Patulin
Molecular Formula
C7H6O4
M.W.
154.10
CAS number
149-29-1
MSDS
Source
Penicillium expansum
Fermentek product Code
PAT-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
105°C-113°C
Solubility test
Clear colorless solution at 10mg/ml DMSO
Names and identifiers

Synonyms:

  • Clavacin
  • Claviformin
  • Mycoin
  • Penicidin
  • Expansin
  • Leucopin
  • Gigantin

IUPAC name: 4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

HSDB: 3522

RTECS#: LV2625000

EU number
205-735-2
Description

Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase.

InChl Key
ZRWPUFFVAOMMNM-UHFFFAOYSA-N
Canonical SMILES
C1C=C2C(=CC(=O)O2)C(O1)O
Solubility ( literature )

Patulin is soluble in DMSO, Methanol, Ethanol, water

Compound Classification
  • Lactone Mycotoxin
  • Cell signaling reagent;
  • apopotosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Retest time
3 Years
Applications

Patulin was suggested as a remedy against common cold and reached clinical trials step in 1943 in Great Britain. However Patulin was found to be inefficient as such.(International Journal of Epidemiology 2004;33:243–246)

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Signal to sort
P

Ochratoxin B

Ochratoxin B
Molecular Formula
C20H19NO6
M.W.
369.37
CAS number
4825-86-9
Source
Aspergillus ochraceus
Fermentek product Code
OCB-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
205°C-222ºC
Names and identifiers

Synonyms 

  • OTB
  • N-[(3R)-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]-L-phenylalanine

HSDB 3438

CHEBI 141524

RTECS SQ7331100

EU number
621-766-8
Description

Ochratoxin B: mycotoxin; dechlorinated derivate of Ochratoxin A.

InChl Key
DAEYIVCTQUFNTM-ABAIWWIYSA-N
Canonical SMILES
CC1CC2=C(C(=C(C=C2)C(=O)NC(CC3=CC=CC=C3)C(=O)O)O)C(=O)O1
Isomeric SMILES
C[C@@H]1CC2=C(C(=C(C=C2)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)O)C(=O)O1
Solubility ( literature )

DMSO, Methanol, Ethanol, Dichloromethane.Not soluble in water

Compound Classification

Ochratoxin B: mycotoxin. oumarin mycotoxin.

Calcium channel blocker.

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Ochratoxin B is the non-chlorinated analogue of the much more extensively studied Ochratoxin A. It is co-produced by the same species of Aspergillus and Penicillium that are associated with food spoilage. Ochratoxin B has received little focused investigation. Its mode of action and its potential hazards might have been inferred from Ochratoxin-A.

Ingredient Reference
Ingredient type
Fermentek product
Ingredient amount
10 ppm
Ingredient Other
Acetonitrile - CAS 75-05-8
Ingredient type
Fermentek product
Ingredient amount
to 100%
Available since
Fermentek Product Category
Signal to sort
O

Ochratoxin A

Ochratoxin A (Benzene Free)
Molecular Formula
C20H18ClNO6
M.W.
403.81
CAS number
303-47-9
Source
Aspergillus ochraceus
Fermentek product Code
OCA-001
Brand/grade
For research
Appearance
White to off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
105°C-112°C
Solubility test
Clear yellowish solution at 10mg/ml Methanol
Names and identifiers

RTECS AY4375000

EU number
206-143-7
Description

Ochratoxin A: mycotoxin.

Ochratoxin A (OTA) is a para-chlorophenolic mycotoxin produced by the mold fungi of the Aspergillus and Penicillium species

InChl Key
RWQKHEORZBHNRI-BMIGLBTASA-N
Canonical SMILES
CC1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)NC(CC3=CC=CC=C3)C(=O)O)Cl
Isomeric SMILES
C[C@@H]1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)Cl
Solubility ( literature )

DMSO, Methanol, Ethanol.

Compound Classification

Isocoumarin mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Ochratoxin A is a potent teratogen in mice, rats, hamsters and chickens, but not apparently in pigs when fed to sows during early pregnancy. Ochratoxin A is known to affect the immune system in a number of mammalian species

Disclaimer
For Research use only
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Signal to sort
O

Nivalenol

Nivalenol
Molecular Formula
C15H20O7
M.W.
312.32
CAS number
23282-20-4
Source
Semisynthetic
Fermentek product Code
NIV-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml Methanol or DMSO
Names and identifiers

IUPAC Name
(3β,4α,7α,12ξ)-3,4,7,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one

RTECS#
YD0167000

EU number
621-749-5
Description

Nivalenol is a type - B trichothecene mycotoxin produced by various Fusarium species, such as Fusarium cerealis, Fusarium graminearum, Fusarium nivale. Besides the natural toxin produced directly by molds, Nivalenol may be also formed by higher plants and by mammals, as a product of biodegradation of other, related thrichothecenes.

InChl Key
UKOTXHQERFPCBU-XLYGLCRNSA-N
Canonical SMILES
CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)O)C)CO
Isomeric SMILES
CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)CO
Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Compound Classification

Chemical class:
Trichothecene mycotoxin

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
trichocethenes are thermostable compounds and are not destroyed in boiling.
Retest time
3 Years
Applications

Nivalenol (0.01 mg/ml) induces apoptosis in HL60 cells (Ueno et al., 1995). Nivalenol was shown to inhibit protein synthesis in rabbit reticulocytes in vitro. Nivalenol inhibited the synthesis of nucleic acids in vitro.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since