Paxilline
Molecular Formula
C27H33NO4
M.W.
435.56
CAS number
57186-25-1
MSDS
Details
Source
Penicillium paxilli
Fermentek product Code
PAX-001
Brand/grade
For research
Specifications
Appearance
White crystalline powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 100mg/ml DMSO; Clear colorless solution at 5mg/ml Acetone
Chemical identification
Names and identifiers
*** Disambiguation: ***
Paxilline, a mycotoxin of penicillium origin, should not be confused with
Paxillin, a signal transducing adaptor protein involved in cell migration (MESH).
IUPAC name
(2R,4bS,6aS,12bS,12cR,14aS)-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-5,6,6a,7,12,12b,12c,13,14,14a-decahydro-2H-chromeno[5',6':6,7]indeno[1,2-b]indol-3(4bH)-one
RTECS: DJ2830000
EU number
637-206-0
Description
Paxilline: a selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels
InChl Key
ACNHBCIZLNNLRS-UBGQALKQSA-N
Canonical SMILES
CC12CCC3C(=CC(=O)C(O3)C(C)(C)O)C1(CCC4C2(C5=C(C4)C6=CC=CC=C6N5)C)O
Isomeric SMILES
C[C@]12CC[C@H]3C(=CC(=O)[C@H](O3)C(C)(C)O)[C@@]1(CC[C@@H]4[C@@]2(C5=C(C4)C6=CC=CC=C6N5)C)O
Further Information
Solubility ( literature )
Acetone, Methanol, and DMSO.
Compound Classification
- tremorgen mycotoxin
- Potassium chanells blocker
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Store under argon.
Other vendors may recommend higher temperatures for storage.
Applications
Potassium channels blocker
Disclaimer
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Transport information
Value
Pg III
Fermentek Product Category
Signal to sort
P
