Nivalenol

Molecular Formula

C15H20O7

M.W.

312.32

CAS number

23282-20-4

Details

Source

Semisynthetic

Fermentek product Code

NIV-001

Brand/grade

For research

Specifications

Appearance

White to Off-White powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless solution at 10 mg/ml Methanol or DMSO

Chemical identification

Names and identifiers

IUPAC Name
(3β,4α,7α,12ξ)-3,4,7,15-Tetrahydroxy-12,13-epoxytrichothec-9-en-8-one

RTECS#
YD0167000

EU number

621-749-5

Description

Nivalenol is a type - B trichothecene mycotoxin produced by various Fusarium species, such as Fusarium cerealis, Fusarium graminearum, Fusarium nivale. Besides the natural toxin produced directly by molds, Nivalenol may be also formed by higher plants and by mammals, as a product of biodegradation of other, related thrichothecenes.

InChl Key

UKOTXHQERFPCBU-XLYGLCRNSA-N

Canonical SMILES

CC1=CC2C(C(C1=O)O)(C3(C(C(C(C34CO4)O2)O)O)C)CO

Isomeric SMILES

CC1=C[C@@H]2[C@]([C@@H](C1=O)O)([C@]3([C@@H]([C@H]([C@H](C34CO4)O2)O)O)C)CO

Further Information

Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Compound Classification

Chemical class:
Trichothecene mycotoxin

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Keep the lid tightly closed.

trichocethenes are thermostable compounds and are not destroyed in boiling.

Retest time

3 Years

Applications

Nivalenol (0.01 mg/ml) induces apoptosis in HL60 cells (Ueno et al., 1995). Nivalenol was shown to inhibit protein synthesis in rabbit reticulocytes in vitro. Nivalenol inhibited the synthesis of nucleic acids in vitro.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Semi-Synthetic

Composition

Ingredient type

Fermentek product

Special Info

Available since

2009