Cancer is most accurately described as a class of diseases characterized by uncontrolled cell growth and division.There are more than a hundred defined types of cancer.

Cancer can occur in nearly every organ or tissue in the body.

Various small molecules are widely used in the research of cancer. Especially in the last decade, cancer research has evolved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a more personalized medical strategy that focuses on the discovery and development of targeted drugs.

These drugs are designed, on a molecular level, to exploit particular genetic dependencies, addictions, and vulnerabilities of cancer cells.

Much current cancer research is concentrated in the areas of programmed cell death, tumor invasion and angiogenesis, tumor immunology, oncogenic signaling, gene expression and copy number, epigenetic regulation, toxicity and chemoresistance, metabolic stress and damage to DNA. Fermentek offers more than 30 unique biochemicals currently being used in cancer research.

Leptomycin B

Leptomycin B
Molecular Formula
C33H48O6
M.W.
540.70
CAS number
87081-35-4
Source
Streptomyces sp.
Fermentek product Code
LPB-001
Brand/grade
For research
Appearance
Lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: 

  • Elactocin
  • Mantuamycin
  • Antibiotic CI 940
  • Antibiotic CL 1957A

RTECS:      RA5390000

EU number
617-954-4
Description

Leptomycin B is an unsaturated, branched-chain fatty acid.

Until 4-jun-2018 Leptomycin had been offered by Fermentek in the form of 1% V/W solution in Methanol/Water mix. Since then, it is offered as lyophylizate.

InChl Key
YACHGFWEQXFSBS-XYERBDPFSA-N
Canonical SMILES
CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
Isomeric SMILES
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
Solubility ( literature )

Leptomycin B is soluble in ethanol, methanol.

Until 4-jun-2018, Fermentek supplied Leptomycin in form of 1% w/v solution in Methanol/water. Since 4-jun-2018 it is as a lyophylisate. 

Compound Classification

Fatty acid antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Retest time
3 Years
Applications

Leptomycin B is an important tool in the study of nuclear export. Leptomycin B is twice as potent as Leptomycin A Leptomycin B (LPB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp. However, recent data (2003) showed that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors. Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
94730-69-5
Title
Change notif 4-jun-2018
Value
Supplied as lyophilisate
Title
comments: safety
Value
The info regarding toxicity/flammability is about the methanol. We offer solid material.
Fermentek Product Category
Research field: Cancer
Protein synthesis inhibitors
Anti Fungal
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
L

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Price
$1.00
Leptomycin_B.gif
Leptomycin_B.gif

Hypericin

Hypericin
Molecular Formula
C30H16O8
M.W.
504.44
CAS number
548-04-9
Source
Hypericium perforatum (plant extract)
Fermentek product Code
HYP-001
Brand/grade
For research
Appearance
Blue – black powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear red solution at 10mg/ml DMSO
Names and identifiers
  • Cyclo-Werrol
EU number
208-941-0
Description

Natural antidepressant. Anti-retroviral agent. A protein kinaze-C inhibitor.

InChl Key
BTXNYTINYBABQR-UHFFFAOYSA-N
Canonical SMILES
CC1=CC(=C2C3=C1C4=C5C(=C(C=C4C)O)C(=O)C6=C(C=C(C7=C6C5=C3C8=C7C(=CC(=C8C2=O)O)O)O)O)O
Solubility ( literature )

Soluble in alkaline aqueous solutions. Soluble in organic bases such as pyridine (red fluorescent solutions) but not in other organic solvents

Compound Classification
  • Perylene analog.
  • Anthraquinone derivative
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Antidepressant. Apoptosis inducer. PKC inhibitor. Antiviral

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS numbers
Value
345224-62-6; 693273-27-7;935869-37-7
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Research field: Cancer
Protein kinase related
Anti Viral
Cancer Related Compounds
Immunosupressors
Immunomodulators
Signal to sort
H

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Price
$1.00
Hypericin.gif
Hypericin.gif

Genistein

Genistein
Molecular Formula
C15H10O5
M.W.
270.20
CAS number
446-72-0
Source
Soy bean (plant extract)
Fermentek product Code
GEN-001
Brand/grade
For research
Appearance
White solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Melting point
295°C-300°C
Solubility test
Clear colorless solution at 50mg/ml DMSO
Names and identifiers

Synonyms: 4′,5,7-Trihydroxyisoflavone

RTECS: NR2392000

 

EU number
207-174-9
Description

Genistein: an isoflavone with anticancer, antiproliferation, and chemopreventive effects. Genistein induces cell differentiation. Genistein inhibits protein histidine kinase.

InChl Key
TZBJGXHYKVUXJN-UHFFFAOYSA-N
Canonical SMILES
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
Solubility ( literature )

Genistein is soluble in DMSO, Ethanol.

Compound Classification

isoflavonoid

histidine kinase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Antibiotics
Research field: Cancer
Signal to sort
G

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Price
$1.00
Genistein.gif
Genistein.gif

Geldanamycin

Geldanamycin
Molecular Formula
C29H40N2O9
M.W.
560.60
CAS number
30562-34-6
MSDS
Source
Streptomyces Hygroscopicus var Geldanus
Fermentek product Code
GEL-001
Brand/grade
For research
Appearance
Yellow solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
Single spot on TLC plates, by multiple methods.
Melting point
260°C-268°C
Crystallinity
Amorphous
Solubility test
Clear yellow solution at 10 mg/ml in DMSO ; Clear yellow solution at 5 mg/ml in Dichloromethane
Names and identifiers

RTECS LX8920000

IUPAC Name : [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate I

Description

Geldanamycin is a benzoquinone ansamycin antibiotic, which binds to Hsp90 (Heat Shock Protein 90) and alters its function. Geldanamycin is a natural product from which several valuable derivates were synthesized. All derivates share its HSP90 inhibition, and vary in overall toxicity and water solubility.

InChl Key
QTQAWLPCGQOSGP-KSRBKZBZSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

Geldanamycin is soluble in DMSO, Dichloromethane. Geldanamycin is insoluble in water.

Compound Classification

Benzoquinone ansamycin antibiotic ;

 

HSP90 inhibitor ;

Tyrosine Kinase Inhibitor ;

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Research fields
Value
Cancer
Fermentek Product Category
Antibiotics
Research field: Cancer
HSP90 inhibitors
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
G

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Price
$1.00
Geldanamycin.gif
Geldanamycin.gif

Fumonisin B2

Fumonisin B2
Molecular Formula
C34H59NO14
M.W.
705.80
CAS number
116355-84-1
MSDS
Source
Fusarium moniliforme
Fermentek product Code
FB2-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution 5 mg/ml Methanol
Names and identifiers

RTECS: TZ8335000

IUPAC name: (2R,2'R)-2,2'-{[(5R,6S,7S,9S,16R,18S,19S)-19-amino-16,18-dihydroxy-5,9-dimethylicosane-6,7-diyl]bis[oxy(2-oxoethane-2,1-diyl)]}disuccinic acid

EU number
601-424-4
Description

Structural analog of Fumonisin B1. Fumonisin B2 is more cytotoxic than Fumonisin B1.

Fumonisin B2 inhibits sphingosine acyl-transterase.

Canonical SMILES
CCCCC(C)C(C(CC(C)CCCCCCC(CC(C(C)N)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Isomeric SMILES
CCCC[C@@H](C)[C@H]([C@H](C[C@@H](C)CCCCCC[C@H](C[C@@H]([C@H](C)N)O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O)OC(=O)C[C@@H](CC(=O)O)C(=O)O
Solubility ( literature )

Methanol

Compound Classification
  • Isoflavonoid
  • Phytoestrogen.
  • Sphingosine acyl-transterase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

sphingosine acyl-transterase inhibitor

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Title
REACH
Value
On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2018.
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Cancer
Apoptosis related
Cancer Related Compounds
Signal to sort
F

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Price
$1.00
Fumonisin_B2.gif
Fumonisin_B2.gif

Fumonisin B1

Fumonisin B1
Molecular Formula
C34H59NO15
M.W.
721.80
CAS number
116355-83-0
MSDS
Source
Fusarium moniliforme
Fermentek product Code
FB1-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5 mg/ml Methanol
Names and identifiers

 

Synonyms:              

Macrofusine

Systematic name:  1,2,3-Propanetricarboxylic acid, 1,1'-(1-(12-amino-4,9,11-trihydroxy-2-methyltridecyl)-2-(1-methylpentyl)-1,2-ethanediyl) ester

RTECS : TZ8350000

EU number
621-436-3
Description

A carcinogenic mycotoxin.

An inhibitor of sphingosine biosynthesis

InChl Key
UVBUBMSSQKOIBE-ZWKVXHQASA-N
Canonical SMILES
CCCCC(C)C(C(CC(C)CC(CCCCC(CC(C(C)N)O)O)O)OC(=O)CC(CC(=O)O)C(=O)O)OC(=O)CC(CC(=O)O)C(=O)O
Isomeric SMILES
CCCC[C@H](C)[C@H]([C@@H](C[C@H](C)C[C@H](CCCC[C@H](C[C@@H]([C@H](C)N)O)O)O)OC(=O)C[C@H](CC(=O)O)C(=O)O)OC(=O)C[C@H](CC(=O)O)C(=O)O
Solubility ( literature )

Slightly soluble in water. Soluble in Acetonitril. Insoluble in Chloroform, Petrol Ether, Hexane.

Compound Classification

Chemical classification

  • Isoflavonoid
  • Phytoestrogen

Biological activities

  • Sphingosine acyl-transterase inhibitor
  • Ceramide-synthase inhibitor
  • Teratogen
  • Carcinogen
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Ingredient type
Fermentek product
Title
Transport information
Value
Not hazardous for transport
Title
TSE
Value
P
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Cancer
Signal to sort
F

Quote for

Price
$1.00
Fumonisin_B1.gif
Fumonisin_B1.gif

Fumagillin

Fumagillin
Molecular Formula
C26H34O7
M.W.
458.54
CAS number
23110-15-8
MSDS
Source
Aspergillus fumigatus
Fermentek product Code
FUG-001
Appearance
Off-white to slight yellow powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
190°C-202°C
Solubility test
Clear colorless solution at 30mg/ml DMSO,
Clear colorless solution at 1mg/ml Ethanol
Names and identifiers

Synonyms:

  • Fumidil B,
  • Amebacilin,

IUPAC Name :   (2E,4E,6E,8E)-10-({(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl}oxy)-10-oxo-2,4,6,8-decatetraenoic acid 

RTECS :             HE1750000

EU number
245-433-8
Description

Antiamoebic. Inhibitor of angiogenesis.

Reproduction effector

InChl Key
NGGMYCMLYOUNGM-CSDLUJIJSA-N
Canonical SMILES
CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C
Isomeric SMILES
CC(=CC[C@@H]1[C@@](O1)(C)[C@H]2[C@@H]([C@@H](CC[C@]23CO3)OC(=O)/C=C/C=C/C=C/C=C/C(=O)O)OC)C
Solubility ( literature )

DMSO, Methanol. alkaline aqueous solutions

Compound Classification

Chemical classification:

Fatty acid antibiotic.

Classification by bio-activity

Antiprotozoal

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Cancer
Anti Protozoal
Anti Parasitic
Cancer Related Compounds
Signal to sort
F

Quote for

Price
$1.00
Fumagillin.gif
Fumagillin.gif

Diacetoxyscirpenol (DAS)

Diacetoxyscirpenol (DAS)
Molecular Formula
C19H26O7
M.W.
366.41
CAS number
2270-40-8
Source
Fusarium sp
Fermentek product Code
DAS-001
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
160°C-165°C
Solubility test
Clear colorless solution at 10mg/ml Methanol ; Clear colorless solution at 10mg/ml dichloromethane
Names and identifiers

Synonyms

  • Anguidine,
  • DAS
  • Diacetoxyscirpenol

RTECS YD0112000

 

EU number
218-873-3
Description

Diacetoxyscirpenol (DAS) also known as Anguidine,  is a mycotoxin belonging to 12,13-epoxytrichothecene group, produced by several Fusarium strains together with some other toxins such as T2 and HT2 toxins.

 DAS inhibits initiation of protein synthesis, causing the death of intensively replicating cells. By the virtue of this effect, DAS possesses teratogenic and anti proliferatory properties. Consequently,  DAS attracts interest as a potential cancer- drug.

 

 

InChl Key
AUGQEEXBDZWUJY-ZLJUKNTDSA-N
Canonical SMILES
CC1=CC2C(CC1)(C3(C(C(C(C34CO4)O2)O)OC(=O)C)C)COC(=O)C
Isomeric SMILES
CC1=C[C@@H]2[C@](CC1)([C@]3([C@@H]([C@H]([C@H]([C@]34CO4)O2)O)OC(=O)C)C)COC(=O)C
Solubility ( literature )

Soluble in moderately polar solvents, such as chloroform, diethyl ether, ethyl acetate, and acetone

Compound Classification
  • trichothecene mycotoxin
  • Apoptosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Diacetoxyscirpenol (Anguidine) and its derivates possess anticancer properties. Diacetoxyscirpenol (Anguidine) inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells. Diacetoxyscirpenol (Anguidine) also has been shown to both potentiate and protect against the cytotoxic effects of other drugs. There were 14 clinical trials reported, all in the area of colorectal tumors and leukemia. No records found after 1985. Apoptosis inducement.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
11011-10-2 ; 22135-66-6 ; 25662-95-7 ; 28776-47-8 ; 109547-11-7 ; 145427-91-4 ; 852223-87-1 ;
Title
Transport information
Value
Pg II
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Regulated Mycotoxins
Trichocothecenes
Research field: Cancer
Apoptosis related
Protein synthesis inhibitors
Signal to sort
D

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Price
$1.00
Diacetoxyscirpenol.gif
Diacetoxyscirpenol.gif

Cordycepin

Cordycepin
Molecular Formula
C10H13N5O3
M.W.
251.24
CAS number
73-03-0
Source
Cordyceps militaris
Fermentek product Code
COR-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear colorless solution at 25mg/ml DMSO
Names and identifiers

Systematic name:
3'-Deoxyadenosine

RTECS:
AU7358610;

EU number
200-791-4
Description

Adenosine analog which occurs naturally in Cordyceps militaris, a mushroom known in traditional medicine.

InChl Key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Canonical SMILES
C1C(OC(C1O)N2C=NC3=C2N=CN=C3N)CO
Isomeric SMILES
C1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C2N=CN=C3N)CO
Solubility ( literature )

Cordycepin is soluble in water, methanol, ethanol, DMSO

Compound Classification

Natural Nucleoside antibiotic.

Purine nucleoside

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Retest time
3 Years
Applications

Cordycepin inhibits growth of various tumor cells in vitro. It may be converted to 3'-deoxyadenosine triphosphate , thus inhibiting ATP-dependent DNA synthesis. Cordycepin is used in the study of messenger RNA transcription.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
CN code
Value
29419000
Fermentek Product Category
Research field: Cancer
Research field: Signal Transduction
Others
Signal to sort
C

Quote for

Price
$1.00
Cordycepin.gif
Cordycepin.gif

Chromomycin A3

Chromomycin A3
Molecular Formula
C57H82O26
M.W.
1 183.25
CAS number
7059-24-7
Source
Streptomyces griseus
Fermentek product Code
CHR-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
180°C-192°C
Solubility test
Clear yellow solution at 10mg/ml of Ethyl Acetate
Names and identifiers

Synonyms:

  • Olivomycin D
  • Toyomycin

IUPAC name:

(1S)-​1-​C-​((2S,​3S)-​7-​{[4-​O-​acetyl-​2,​6-​dideoxy-​3-​O-​(2,​6-​dideoxy-​4-​O-​methyl-​α-​D-​lyxo-​hexopyranosyl)-​β-​D-​lyxo-​hexopyranosyl]​oxy}-​3-​{[4-​O-​acetyl-​2,​6-​dideoxy-​3-​C-​methyl-​α-​L-​arabino-​hexopyranosyl-​(1→3)-​2,​6-​dideoxy-​β-​D-​arabino-​hexopyranosyl-​(1→3)-​2,​6-​dideoxy-​β-​D-​arabino-​hexopyranosyl]​oxy}-​5,​10-​dihydroxy-​6-​methyl-​4-​oxo-​1,​2,​3,​4-​tetrahydroanthracen-​2-​yl)-​5-​deoxy-​1-​O-​methyl-​D-​xylulose

RTECS  GB7875000

 

EU number
230-348-0
Chemical name
Chromomycin A3
Description

Chromomycin A3 is an antibiotic of the Anthraquinone group. It inhibits RNA synthesis by interfering with the binding of the transcription factors Sp1 and Sp3 to the DNA. Chromomycin A3 exhibits anti-bacterial, anti-fungal and antitumor activitie. Chromomycin A3 gains interest as a candidate anticancer drug.  is also used as a fluorescent dye to determine DNA concentrations. 

InChl Key
ZYVSOIYQKUDENJ-WKSBCEQHSA-N
Canonical SMILES
CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O
Isomeric SMILES
C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@H]2[C@@H](CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)O[C@H]5C[C@H]([C@H]([C@H](O5)C)OC(=O)C)O[C@@H]6C[C@H]([C@H]([C@H](O6)C)OC)O)O)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]7C[C@H]([C@@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@H]([C@@H](O8)C)OC(=O)C)(C)O)O
Solubility ( literature )

DMSO, Ethyl Acetate, Methanol, Ethanol

Compound Classification

Glycosidic antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Membrane-impermeant, G/C-specific fluorescent DNA-binding dye.
  • Antibacterial antibiotic.
  • Antitumor antibiotic that inhibits RNA synthesis, especially in solid tumors.
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
PG I
Title
TSE
Value
F
Title
sig
Value
230752
Fermentek Product Category
Antibiotics
Research field: Cancer
Anti Fungal
Anti Bacterial
Anti Tumor agents
Signal to sort
C
Chromomycin_A3.gif
Chromomycin_A3.gif
Subscribe to Research field: Cancer