Enzyme inhibitors:

These compounds block the action of miscelaneous enzymes. We intentionally did not include proteine kinaze inhibitors into this category, preferring creation of a separate category for these.

Enniatin A

Enniatin A
Molecular Formula
C36H63N3O9
M.W.
681.90
CAS number
2503-13-1
Source
Fusarium sp.
Fermentek product Code
ENA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
121°C-125°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

Synonyms:

Chemical names:  Fusafungine ;   Enniatin-A

IUPAC: (3S,9S,12R,15S,18R)-9,15-bis[(2S)-butan-2-yl]-3-[(2R)-butan-2-yl]-4,10,16-trimethyl-6,12,18-tri(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

A Fusarium produced depsipeptide ionophore

RTECS#  

Condensed IUPAC:  cyclo[N(Me)Ile-D-OVal-N(Me)Ile-DL-OVal-N(Me)aIle-D-OVal]

EU number
215-737-5
Description

Enniatin A is a least abundant commponent of the Enniatin-complex. It has been recently made available as a pure compound, thanks to the most advanced preparative HPLC methods.

InChl Key
TWHBYJSVDCWICV-BHZTXFQCSA-N
Canonical SMILES
CCC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)CC)C)C(C)C)C(C)CC)C)C(C)C
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)[C@@H](C)CC)C)C(C)C)[C@@H](C)CC)C)C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMSO, DMF.

Compound Classification

Chemical classification:  Cyclic depsipeptide.

Biological classification:

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Natural enniatins occure as a mixture of several related analogs, known as "Enniatins", or "Enniatin complex". 

Enniatins occure in nature in the mycelia of some Fusarium species. Being cyclic and hydrophopic molecules, enniatins are able to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin has not previously been available for investigation.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS Numbers
Value
2503-13-1; 4530-29-4
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Immunomodulators
Ionophores
Signal to sort
E

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Price
$1.00
Enniatin_A.gif
Enniatin_A.gif

Enniatin B

Enniatin B
Molecular Formula
C33H57N3O9
M.W.
639.82
CAS number
917-13-5
Source
Fusarium sp.
Fermentek product Code
ENB-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
172°C-176°C
Solubility test
Clear colorless solution at 10mg/ml of Dichloromethane or Methanol
Names and identifiers

 

Synonyms:

Chemical names:

IUPAC:

(3S,6R,9S,12R,15S,18R)-4,10,16-trimethyl-3,6,9,12,15,18-hexa(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone

IUPAC Condensed name, as an oligopeptide
cyclo[N(Me)Val-D-OVal-N(Me)Val-D-OVal-N(Me)Val-D-OVal]

RTECS n.a.

Description

Enniatin B is the most studied of four major analogues of the enniatin complex.

InChl Key
MIZMDSVSLSIMSC-VYLWARHZSA-N
Canonical SMILES
CC(C)C1C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N(C(C(=O)OC(C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Isomeric SMILES
CC(C)[C@H]1C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N([C@H](C(=O)O[C@@H](C(=O)N1C)C(C)C)C(C)C)C)C(C)C)C(C)C)C)C(C)C
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Ionophores
Signal to sort
E

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Price
$1.00
Enniatin_B.gif
Enniatin_B.gif

Chaetocin

Chaetocin
Molecular Formula
C30H28N6O6S4
M.W.
696.84
CAS number
28097-03-2
Source
From Chaetomium sp
Fermentek product Code
CHT-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 25 mg/ml DMSO
Names and identifiers

Synonyms

  • Chetocin
  • Chaetocin
  • (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS)-2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio-11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4,4'-tetrone

RTECS: FM3032000

EU number
636-696-3
Description

A fungal metabolite which inhibits G9a histone methyltransferase.

InChl Key
PZPPOCZWRGNKIR-PNVYSBBASA-N
Canonical SMILES
CN1C(=O)C23CC4(C(N2C(=O)C1(SS3)CO)NC5=CC=CC=C54)C67CC89C(=O)N(C(C(=O)N8C6NC1=CC=CC=C71)(SS9)CO)C
Isomeric SMILES
c12c(N[C@@H]3N4[C@@]5(C[C@@]23[C@@]23c6c(N[C@@H]2N2[C@@]7(C3)C(N([C@@](C2=O)(SS7)CO)C)=O)cccc6)C(N([C@@](CO)(C4=O)SS5)C)=O)cccc1
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
31794-18-0
Title
Inhibitor of:
Value
G9a histone methyltransferase
Title
Transport information
Value
Not hazardous for transport
Title
Research Areas
Value
HIV
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Other mycotoxins
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Research field: Signal Transduction
Signal to sort
C

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Price
$1.00
Chaetocin.gif
Chaetocin.gif

Epigallocatechin Gallate

Epigallocatechin Gallate
Molecular Formula
C22H18O11
M.W.
458.40
CAS number
989-51-5
Source
Extracted from Green Tea (leaves)
Fermentek product Code
EPG-001
Brand/grade
For research
Appearance
White to Beige lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml H2O
Names and identifiers

RTECS KB5200000

EU number
619-381-5
Chemical name
[(2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl] 3,4,5-trihydroxybenzoate
Description

Epigallocatechin is a phenolic antioxidant found in a number of plants such as green and black tea.
Epigallocatechin inhibits cellular oxidation and prevents free radical damage to cells. 

 

InChl Key
WMBWREPUVVBILR-WIYYLYMNSA-N
Canonical SMILES
C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Isomeric SMILES
C1[C@H]([C@H](OC2=CC(=CC(=C21)O)O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O
Compound Classification

- Antioxidant

- Potential cancer-preventive agent. 

- Inhibitor of Telomerase

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Epigallocatechin is being studied as a potential cancer chemo preventive agent.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Signal to sort
E

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Price
$1.00
Epigallocatechin_gallate__EGCG_.gif
Epigallocatechin_gallate__EGCG_.gif

Equisetin

Equisetin
Molecular Formula
C22H31NO4
M.W.
373.49
CAS number
57749-43-6
MSDS
Source
Fusarium equiseti
Fermentek product Code
EQU-001
Brand/grade
For research
Appearance
Light tan to tan or off-white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10 mg/ml of Methanol or DMSO
Names and identifiers

IUPAC:

(2S)-4-({(1S,2R,4aS,6R,8aR)-1,6-Dimethyl-2-[(1E)-1-propen-1-yl]-1,2,4a,5,6,7,8,8a-octahydro-1-naphthalenyl}carbonyl)-5-hydroxy-2-(hydroxymethyl)-1-methyl-1,2-dihydro-3H-pyrrol-3-one

RTECS KD7986000

EU number
303-396-6
Description

Antibiotic from Fusarium equiseti; derivative of N-methyl-2,4-pyrollidone

InChl Key
QNQBPPQLRODXET-HMHJLHGTSA-N
Canonical SMILES
CC=CC1C=CC2CC(CCC2C1(C)C(=C3C(=O)C(N(C3=O)C)CO)O)C
Isomeric SMILES
C/C=C/[C@@H]1C=C[C@@H]2C[C@@H](CC[C@H]2[C@]1(C)/C(=C\3/C(=O)[C@@H](N(C3=O)C)CO)/O)C
Solubility ( literature )

Equisetin is reported to be soluble in DMF or DMSO, moderately soluble in methanol or ethanol and poorly soluble in water.

Equisetin solubility as reported in an original patent,

  • in acetone of 660 mg./ml.,
  • in ethanol of 330 mg./ml.,
  • in methanol of 220 mg./ml.,
  • in hexane of 0.8 mg./ml.,
  • in water of 0.3 mg./ml.

Elemental analysis: C, 70.95; H, 8.39; N, 3.14;

Compound Classification

Chemical classification:

Tetramic acid class antibiotic.

Classification by Bioactivity:

HIV-integrase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Equisetin inhibits some ATPases, and affects several energy related mitochondrial enzymes.

Equisetin was also shown to inhibit (in-vitro) HIV-1 integrase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Amber-glass vial.
Available since
Title
Transport
Value
Not regulated
Title
Animal rawmat
Value
No
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Anti Bacterial
Anti Viral
Signal to sort
E

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Price
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Equisetin.gif
Equisetin.gif

Wortmannin

Wortmannin
Molecular Formula
C23H24O8
M.W.
428.44
CAS number
19545-26-7
Source
Talaromyces (Penicillium) wortmannii
Fermentek product Code
WOR-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-240°C
Solubility test
Clear colorless to faint yellow solution at 5 mg/ml Methanol;
Clear colorless to faint yellow solution at 10mg/ml Ethyl Acetate;
Names and identifiers

Synonyms:

  • Wartmannin
  • Antibiotic SL-2052

Systematic Name:

  • (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione

RTECS: CB641000

EU number
606-337-5
Chemical name
Wortmannin
Description

Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866

InChl Key
QDLHCMPXEPAAMD-QAIWCSMKSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Solubility ( literature )

DMSO, Methanol.

Wortmannin is unstable in aqueous and ethanolic solutions.

Compound Classification
  • chemical class: Androstadiene.
  • phospholipase D inhibitor.
  • phosphatidylinositol 3-kinase inhibitor.
  • Immunosupressor.
  • Antifungal.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications

Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS number:
Value
1405-03-4
Title
Transport information
Value
PG I
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Protein kinase related
Anti Fungal
Others
Signal to sort
W

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Price
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Wortmannin.gif
Wortmannin.gif

Tunicamycin (complex)

Tunicamycin (complex)
Molecular Formula
C39H64N4O16 (for n=10, "Tunicamycin VII")
CAS number
11089-65-9
MSDS
Source
Streptomyces chartreusis
Fermentek product Code
TUN-001
Brand/grade
For research
Appearance
Off white to tan powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
4 spots matching standard, no other spots, by multiple methods.
Melting point
≥210°C
Solubility test
Clear solution at 5mg/ml of Methanol,
Clear solution at 50mg/ml of DMSO
Names and identifiers

RTECS: YO7980200

EU number
601-012-4
Description

Tunicamycin is a mixture of homologous nucleoside antibiotics.
The main homologs differ in the length of the fatty chain moiety.
The following table defines the four main Tunicamycin homologs.

  • Tunicamycin A, aka Tunicamycin V, n=9, mw=817;
  • Tunicamycin B, aka Tunicamycin VII, n=10, mw=831;
  • Tunicamycin C, aka Tunicamycin II, n=8, mw=845;
  • Tunicamycin D, aka Tunicamycin X, n=11, mw=859
Solubility ( literature )
  • Tunicamycin is soluble in DMSO, alkaline water, hot methanol.
  • Practically insoluble in acetone, ethyl acetate.
  • Unstable in acidic solutions
Compound Classification
  • nucleoside antibiotic
  • antiviral
  • inhibitor of glucosylation of proteins
  • tunicamycin causes cell cycle arrest in G1 phase
  • Tunicamycin has anti-angiogenesis properties.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Tunicamycins inhibit protein glycosylation. They arrest cell cycle in late G1As Tunicamycin affects cell membrane permeability, it was shown to increase production of antibiotics, such as streptomycin PRODUCT USE A tool to study glycoprotein synthesis in a wide variety of biological systems. Family of nucleoside antibiotics produced by Streptomyces lysosuperificus. Tunicamycin interferes with glycoprotein synthesis in yeast and mammalian systems and enhances antiviral and anticellular activity of interferon. Possesses cell - surface altering activity. Inhibits the transfer of N-acetylglucosamine-1-phosphate from UDP -N- acetylglucosamine to dolichol monophosphate and thereby blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi and viruses.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg II
Title
Deleted CAS Registry Numbers
Value
11118-26-6
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Protein kinase related
Anti Bacterial
Anti Viral
Research field: Signal Transduction
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T

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Trichostatin A

Trichostatin A
Molecular Formula
C17H22N2O3
M.W.
302.37
CAS number
58880-19-6
MSDS
Source
Streptomyces platensis
Fermentek product Code
TRA-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
138°C-150°C
Solubility test
Clear colorless solution at 5mg/ml Methanol; Clear yellow solution at 20mg/ml DMSO
Names and identifiers

Synonyms:

  • 2,​4-​Heptadienamide, 7-​[4-​(dimethylamino)​phenyl]​-​N-​hydroxy-​4,​6-​dimethyl-​7-​oxo-​, (2E,​4E,​6R)​-
  • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
  • TSA
  • (R)-(+)-Trichostatin A

 

 

EU number
611-758-2
Description

Trichostatin A is an antifungal antibiotic.

Trichostatin A is a potent, reversible inhibitor of histone deacetylase (HDAC)

InChl Key
RTKIYFITIVXBLE-QEQCGCAPSA-N
Canonical SMILES
CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Isomeric SMILES
C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
Solubility ( literature )

DMSO, Ethanol

Compound Classification

HDAC inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Signal to sort
T
Trichostatin_A.gif
Trichostatin_A.gif

Triacsin C

Triacsin C
Molecular Formula
C11H17N3O
M.W.
207.27
CAS number
76896-80-5
MSDS
Source
Streptomyces aureofaciens
Fermentek product Code
TRC-001
Brand/grade
For research
Appearance
Off-white to Dark yellow powder
Purity by HPLC
≥90% ; refer to CoA for more data
Purity By TLC
≥95% ; refer to CoA for more data
Solubility test
Clear yellowish to yellow solution at 5mg/ml of Methanol or DMSO
Names and identifiers

Synonyms

  • 2E, 4E, 7E-Undecatriene-1-triazene
  • 1-hydroxy-3-(2',4',7'-undecatrienylidine)triazene

 

EU number
616-408-2
Chemical name
2,4,7-Undecatrienal, nitrosohydrazone, (2E,4E,7E)-
Description

Triacsin C, an analog of polyunsaturated fatty acid. A potent vasodilator.

InChl Key
NKTGCVUIESDXPU-YLEPRARLSA-N
Canonical SMILES
CCCC=CCC=CC=CC=NNN=O
Isomeric SMILES
CCC/C=C/C/C=C/C=C/C=N/NN=O
Solubility ( literature )

Soluble to 25 mM in DMSO (lit)

Compound Classification

Chemical classification:

  • Triazene class compound
  • Polyunsaturated fatty acid analog.

Classification by bioactivities:

  • Arachidonoyl-CoA synthetase inhibitor
  • Inhibits Synthesis of triacylglycerol and phospholipid
  • Apoptosis inhibitor
  • Vasodilator
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Attention: this compound may deteriorate quickly if stored improperly
Retest time
1.5 Years
Applications

Selectively inhibits arachidonoyl-CoA synthetase in intact cells. Inhibits the nonspecific acyl-CoA synthetase in cell sonicates. Inhibits neutrophil functions. Inhibits lipid synthesis and cell proliferation in Raji lymphoma cells. Induces apoptosis in cancer cell lines and inhibits human lung cancer cell xenograft tumor growth in mice.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Inhibitor of:
Value
Selective inhibitor of acyl-CoA synthetase
Title
Transport information
Value
Not hazardous for transport
Title
Specifications updated 24-October 2017
Value
Purity ≥90% by HPLC
Fermentek Product Category
Enzyme-inhibitors
Cardiovascular agents
Vasodilator Agents
Others
Signal to sort
T

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Price
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Triacsin_C.gif
Triacsin_C.gif

Staurosporine

Staurosporine
Molecular Formula
C28H26N4O3
M.W.
466.53
CAS number
62996-74-1
MSDS
Source
Streptomyces staurosporeus
Fermentek product Code
STA-001
Appearance
Off-white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-275°C
Solubility test
Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO
Names and identifiers

Synonyms:  Antibiotic AM 2282; 

RTECS: KD5084000   ;  attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number
613-127-7
Chemical name
Staurosporine
Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C.   Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key
HKSZLNNOFSGOKW-FYTWVXJKSA-N
Canonical SMILES
CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Isomeric SMILES
C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC
Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification
  • Chemical classification: Indolocarbazole alkaloid
  • Bio-activity: PKC inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications
  • Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
  • May participate in antigen-induced T-cell activation;
  • Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Deleted CAS numbers
Value
109189-95-9
Title
Safety comments
Value
Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.
Title
identity comments
Value
HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Apoptosis related
Protein kinase related
Anti Fungal
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Signal to sort
S

Quote for

Price
$1.00
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