Wortmannin
Molecular Formula
C23H24O8
M.W.
428.44
CAS number
19545-26-7
Details
Source
Talaromyces (Penicillium) wortmannii
Fermentek product Code
WOR-001
Brand/grade
For research
Specifications
Appearance
White to slight yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-240°C
Solubility test
Clear colorless to faint yellow solution at 5 mg/ml Methanol;
Clear colorless to faint yellow solution at 10mg/ml Ethyl Acetate;
Clear colorless to faint yellow solution at 10mg/ml Ethyl Acetate;
Chemical identification
Names and identifiers
Synonyms:
- Wartmannin
- Antibiotic SL-2052
Systematic Name:
- (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione
RTECS: CB641000
EU number
606-337-5
Chemical name
Wortmannin
Description
Wortmannin is a steroid metabolite of the fungus Talaromyces wortmannii. It is a specific covalent inhibitor of phosphoinositide 3-kinases. Wortmannin has been used as precursor of an experimental anti-cancer drug PX-866
InChl Key
QDLHCMPXEPAAMD-QAIWCSMKSA-N
Canonical SMILES
CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C
Isomeric SMILES
CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C
Further Information
Solubility ( literature )
DMSO, Methanol.
Wortmannin is unstable in aqueous and ethanolic solutions.
Compound Classification
- chemical class: Androstadiene.
- phospholipase D inhibitor.
- phosphatidylinositol 3-kinase inhibitor.
- Immunosupressor.
- Antifungal.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Protect from moisture! Hygroscopic substance.
Retest time
3 Years
Applications
Wortmannin is an inhibitor of phosphatidyl-inositol 3-kinase Wortmannin inhibits the growth of mammary tumors despite the existence of a novel wortmannin-insensitive phosphatidylinositol-3-kinase. Wortmannin inhibits repair of DNA double-strand breaks in irradiated normal human cells. Wortmannin was shown to have enhancing influence on memory and impair learning abilities. .
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
Deleted CAS number:
Value
1405-03-4
Title
Transport information
Value
PG I
Fermentek Product Category
Signal to sort
W
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