Cytochalasin D

Cytochalasin D
Molecular Formula
C30H37NO6
M.W.
507.62
CAS number
22144-77-0
MSDS
Source
Zygosporium mansonii
Fermentek product Code
CYD-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
230°C-245°C
Solubility test
Clear colorless solution at 25mg/ml DMSO, Clear colorless solution at 5mg/ml Ethanol
Names and identifiers

Synonyms: Zygosporin A

Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

EU number
244-804-1
Description

Cytochalasin D is a cell permeable mycotoxin, which causes both the association and dissociation of actin subunits. Cytochalasin D disrupts actin filaments and inhibits actin polymerization.

InChl Key
SDZRWUKZFQQKKV-JHADDHBZSA-N
Canonical SMILES
CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O
Isomeric SMILES
C[C@H]1C/C=C/[C@H]2[C@@H](C(=C)[C@H]([C@@H]3[C@@]2([C@@H](/C=C/[C@@](C1=O)(C)O)OC(=O)C)C(=O)N[C@H]3CC4=CC=CC=C4)C)O
Solubility ( literature )

DMSO, Ethanol, Methanol

Compound Classification
  • Macrolide indol mycotoxin
  • Cytochalasin
  • Actin inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Cytochalasins are used as tools in cytological research, and in the field of actin polymerization. Cytochalasin D is 10 times more effective than cytochalasin B and does not inhibit glucose transport across cell membranes.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
11032-97-6 ; 25852-72-6 ; 28455-04-1 ; 69401-32-7
Title
TSE
Value
V
Title
sig
Value
250255
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Cytochalasins
Enzyme-inhibitors
Apoptosis related
Anti Viral
Cancer Related Compounds
Anti Tumor agents
Signal to sort
C

Quote for

Price
$1.00
Cytochalasin_D.gif
Cytochalasin_D.gif

Castanospermine

Castanospermine
Molecular Formula
C8H15NO4
M.W.
189.21
CAS number
79831-76-8
Source
Castanospermum australe (plant extract)
Fermentek product Code
CAS-001
Brand/grade
For research
Appearance
White to off-white solid.
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
202°C-215°C
Names and identifiers

Synonyms:

  • 1,6,7,8-Tetrahydroxyoctahydroindolizine
EU number
616-743-4
Description

Alkaloid extracted from an australian legume. Potent inhibitor of α- and β-glucosidase activity in fibroblast extracts; inhibits the glycoprotein processing cycle. Exhibits antiviral properties. Inhibits angiogenesis.

InChl Key
JDVVGAQPNNXQDW-TVNFTVLESA-N
Canonical SMILES
C1CN2CC(C(C(C2C1O)O)O)O
Isomeric SMILES
C1CN2C[C@@H]([C@H]([C@@H]([C@H]2[C@H]1O)O)O)O
Solubility ( literature )

Soluble in water.

Compound Classification

Indolizidine alkaloid

Glycosidase Inhibitor

Angiogenesis inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Potent inhibitor of α- and β-glucosidases. 
Inhibits HIV infectivity. 
Inhibits angiogenesis. 
Inhibits thyroglobulin secretion. 
Antitumor activty. 
Inhibits protein glycosylation.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Plant-derived
Angiogenesis related
Anti Viral
Signal to sort
C

Quote for

Price
$1.00
Castanospermine.gif
Castanospermine.gif

Brefeldin A

Brefeldin A
Molecular Formula
C16H24O4
M.W.
280.36
CAS number
20350-15-6
Source
Eupenicillium brefeldianum
Fermentek product Code
BRF-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
198°C-215°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol
Names and identifiers

Synonyms:

  •         Nectrolide;
  •         Synergisidin;
  •         Cyanaein;
  •         Ascotoxin
  •         Cyanein
  •         Decumbin
  •         Brefeldin A

EC# :     606-528-3

 Systematic name:

(1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one

RTECS: GY8410000

EU number
606-528-3
Description

Brefeldin A is a macrocyclic lactone from fungal source, exhibiting a wide range of antibiotic activity.

InChl Key
KQNZDYYTLMIZCT-HHMYAMTESA-N
Canonical SMILES
CC1CCCC=CC2CC(CC2C(C=CC(=O)O1)O)O
Isomeric SMILES
C[C@H]1CCC/C=C/[C@@H]2C[C@@H](C[C@H]2[C@@H](/C=C\C(=O)O1)O)O
Solubility ( literature )

Methanol, Ethanol, Dichloromethane, DMSO, acetone or ethyl acetate

Compound Classification
  • Macrocyclic lactone antibiotic.
  • Antifungal
  • Antiviral
  • Protein Synthesis Inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Inhibitor of protein translocation from endoplasmic reticulum (ER) to the Golgi apparatus.
Inhibitor of intracellular protein transport and protein secretionA macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.

 

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

NotAnimal

No animal ingredients

NotGMO

Product natural

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
sig
Value
203729
Title
TSE
Value
F
Fermentek Product Category
Antibiotics
Apoptosis related
Protein synthesis inhibitors
Anti Viral
Immunomodulators
Signal to sort
B

Quote for

Price
$1.00
Brefeldin_A.gif
Brefeldin_A.gif

Borrelidin

Borrelidin
Molecular Formula
C28H43NO6
M.W.
489.64
CAS number
7184-60-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
BOR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
106°C-114°C
Solubility test
Clear colorless solution at 10 mg/ml of Methanol or DMSO or Chloroform
Names and identifiers
  • Treponemycin
  • Cyclopentanecarboxylic acid
  • 2-[(4E,6E)-7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl]cyclopentanecarboxylic acid
  • RTECS ED8750000
EU number
811-923-0
Description

Borrelidin is a macrolide-polyketide antibiotic displaying anti-viral, anti-bacterial, anti-malarial, and anti-angiogenic properties.

InChl Key
OJCKRNPLOZHAOU-UGKRXNSESA-N
Canonical SMILES
CC1CC(CC(C(C(=CC=CCC(OC(=O)CC(C(C1)C)O)C2CCCC2C(=O)O)C#N)O)C)C
Isomeric SMILES
C[C@H]1C[C@H](C[C@@H]([C@H](/C(=C\C=C\C[C@H](OC(=O)C[C@@H]([C@H](C1)C)O)[C@@H]2CCC[C@H]2C(=O)O)/C#N)O)C)C
Solubility ( literature )

Borrelidin is soluble in DMF, DMSO, Ethanol, Ethyl acetate, Methanol

Compound Classification
  • Cyclin-dependent kinase (CDK) inhibitor ;
  • Antiviral agent
  • Anti- Angiogenetic agent
  • Apoptosis inducer
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
2 Years
Applications

Borrelidin, a potent antifungal agent

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
1403-11-8; 97328-74-0
Title
Transport information
Value
Not hazardous for transport
Title
Inhibitor of:
Value
threonyl aminoacyl-tRNA synthetase; cyclin-dependent kinase (CDK).
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Protein synthesis inhibitors
Anti Protozoal
Anti Bacterial
Anti Viral
Cancer Related Compounds
Signal to sort
B

Quote for

Price
$1.00
Borrelidin.gif
Borrelidin.gif

Aphidicolin

Aphidicolin
Molecular Formula
C20H34O4
M.W.
338.48
CAS number
38966-21-1
MSDS
Source
Nigrospora oryzae
Fermentek product Code
APH-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
228°C-233°C
Solubility test
Clear colorless solution at 50mg/ml of DMSO, 10mg/ml of Methanol
Names and identifiers

 RTECS: PB9185000

EU number
609-602-3
Description

Aphidicolin is an antiviral antibiotic produced by Nigrospora oryzae and other fungi. Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis, while having no effect on non-multiplying cells.

InChl Key
NOFOAYPPHIUXJR-APNQCZIXSA-N
Canonical SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
Isomeric SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
Solubility ( literature )

Methanol, DMSO

Compound Classification

tetracyclic mycotoxin

DNA polymerase A inhibitor

Antiviral

Chemical classification:

  • A tetracyclic diterpene antibiotic.

Biological classification:

  • Antiviral, antimithotical
  • Specific inhibitor of DNA polymerase A

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.Aphidicolin is a tool in cell proliferation and differentiation research. Aphidicolin may possibly be used for controlling excessive cell proliferation in cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Additional Comments
Value
Elemental analysis may be performed for some lots
Title
Transport information
Value
Not hazardous for transport
Title
sig
Value
178273
Title
TSE
Value
F
Fermentek Product Category
Antibiotics
Cytotoxic agents
Research field: Cancer
Apoptosis related
Anti Viral
Anti Tumor agents
DNA replication inhibitors
Signal to sort
A

Quote for

Price
$1.00
Aphidicolin.gif
Aphidicolin.gif
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