Aphidicolin
Molecular Formula
C20H34O4
M.W.
338.48
CAS number
38966-21-1
MSDS
Source
Nigrospora oryzae
Fermentek product Code
APH-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
228°C-233°C
Solubility test
Clear colorless solution at 50mg/ml of DMSO, 10mg/ml of Methanol
Names and identifiers

 RTECS: PB9185000

EU number
609-602-3
Description

Aphidicolin is an antiviral antibiotic produced by Nigrospora oryzae and other fungi. Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis, while having no effect on non-multiplying cells.

InChl Key
NOFOAYPPHIUXJR-APNQCZIXSA-N
Canonical SMILES
CC12CCC(C(C1CCC3C24CCC(C(C3)C4)(CO)O)(C)CO)O
Isomeric SMILES
C[C@]12CC[C@H]([C@@]([C@@H]1CC[C@@H]3[C@@]24CC[C@@]([C@H](C3)C4)(CO)O)(C)CO)O
Solubility ( literature )

Methanol, DMSO

Compound Classification

tetracyclic mycotoxin

DNA polymerase A inhibitor

Antiviral

Chemical classification:

  • A tetracyclic diterpene antibiotic.

Biological classification:

  • Antiviral, antimithotical
  • Specific inhibitor of DNA polymerase A

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Applications

Aphidicolin inhibits the growth of eukaryotic cells and certain animal viruses by selectively inhibiting the cellular replication of DNA polymerase II or the viral-induced DNA polymerases. The drug may be useful for controlling excessive cell proliferation in patients with cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.Aphidicolin is a tool in cell proliferation and differentiation research. Aphidicolin may possibly be used for controlling excessive cell proliferation in cancer, psoriasis or other dermatitis with little or no adverse effect upon non-multiplying cells.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Additional Comments
Value
Elemental analysis may be performed for some lots
Title
Transport information
Value
Not hazardous for transport
Title
sig
Value
178273
Title
TSE
Value
F
Signal to sort
A