Anti Tumor agents | Fermentek

Research area: Multi-drug resistance

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Thapsigargin

Molecular Formula

C34H50O12

M.W.

650.75

CAS number

67526-95-8

MSDS

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Details

Source

Thapsia garganica

Fermentek product Code

THP-001

Brand/grade

For research

Specifications

Appearance

White to faint yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless solution at 10mg/ml Acetonitrile

Chemical identification

Names and identifiers

Synonyms: octanoic acid {3S-[3alpha,3abeta,4alpha,6beta,6abeta,7beta,8alpha(Z),9balpha]}-6-(acetoxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)-azuleno[4,5-b]furan-7-yl ester

RTECS RH0352700

EU number

614-076-3

Description

Thapsigargin is a cell-permeable, tumor promoting sesquiterpene lactone. A tight-binding inhibitor of intracellular calcium (SERCA) pumps (sarco/endoplasmic reticulum Ca²⁺ ATPase). Chemically it is classified as a sesquiterpene lactone antibiotic.

A study from the University of Nottingham showed promising results for its use against Covid-19 and other coronavirus.

InChl Key

IXFPJGBNCFXKPI-FSIHEZPISA-N

Canonical SMILES

CCCCCCCC(=O)OC1C2C(=C(C1OC(=O)C(=CC)C)C)C3C(C(CC2(C)OC(=O)C)OC(=O)CCC)(C(C(=O)O3)(C)O)O

Isomeric SMILES

CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O

Further Information

Solubility ( literature )

DMSO, Acetonitril, Ethanol, Methanol, Dichloromethane

Compound Classification

Sesquiterpene lactone
SERCA inhibitor
Apoptosis related antibiotic

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Hygroscopic substance.

Protect from moisture

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

1998

Other Fields

Title

Transport information

Value

Not hazardous for transport

Title

TSE category

Value

Fermentek Product Category

Read more about Thapsigargin

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Tenuazonic acid (Cu salt)

Tenuazonic acid – Copper salt

Molecular Formula

C20H28CuN2O6

M.W.

455.99

CAS number

76569-74-9

MSDS

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Details

Source

Alternaria sp.

Fermentek product Code

TNZ-001

Brand/grade

For research

Specifications

Appearance

Light blue-greenish powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear blue-green solution at 10mg/ml Dichloromethane

Chemical identification

Names and identifiers

Synonyms:

3-Pyrrolin-2-one, 3-acetyl-5-sec-butyl-4-hydroxy-, L-

RTECS: UY7425000

Description

Tenuazonic acid is a natural mycotoxin, inhibitor of protein synthesis. Tenuazonic acid is offered as its Cuprum salt.

InChl Key

LLXUERDQXVXQAY-UHFFFAOYSA-N

Canonical SMILES

CCC(C)C1C(=C(C(=O)N1)C(=O)C)O.CCC(C)C1C(=C(C(=O)N1)C(=O)C)O.[Cu]

Further Information

Solubility ( literature )

Soluble in DMSO, pure ethanol, methanol

Compound Classification

Pyrrolidinone mycotoxin
Tenuazonic Acid Copper Salt is an antineoplastic agent and mycotoxin. It Inhibits protein synthesis, though which it has been shown inhibiting TPA-induced ornithine decarboxylase activity. Lack of ornithine decarboxylase has been shown to eventually cause DNA damage induced apoptosis. It has also been shown to inhibit photosystem II.

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

This is a potential antineoplastic agent

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Semi-Synthetic

Composition

Ingredient type

Fermentek product

Special Info

Available since

2013

Other Fields

Title

Transport information

Value

Pg III

Fermentek Product Category

Mycotoxins

Alternaria toxins

Cytotoxic agents

Read more about Tenuazonic acid (Cu salt)

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Staurosporine

Molecular Formula

C28H26N4O3

M.W.

466.53

CAS number

62996-74-1

MSDS

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Details

Source

Streptomyces staurosporeus

Fermentek product Code

STA-001

Specifications

Appearance

Off-white to light yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

255°C-275°C

Solubility test

Clear colorless solution at 5mg/ml Ethyl Acetate,
Clear yellow solution at 25mg/ml DMSO

Chemical identification

Names and identifiers

Synonyms: Antibiotic AM 2282;

RTECS: KD5084000 ; attention: This RTECS record belongs to the Hydrochloride salt of Staurosporine, rather than the free base form.

EU number

613-127-7

Chemical name

Staurosporine

Description

Staurosporine is a cell permeable inhibitor of protein kinases, including protein kinase-C. Inhibitor of nuclear factor kappa B kinase beta subunit.

InChl Key

HKSZLNNOFSGOKW-FYTWVXJKSA-N

Canonical SMILES

CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Isomeric SMILES

C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

Further Information

Solubility ( literature )

DMSO, Methanol, Ethanol, Ethyl Acetate. Water insoluble

Compound Classification

Chemical classification: Indolocarbazole alkaloid
Bio-activity: PKC inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Keep the lid tightly closed.

Avoid exposing to strong direct light.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Pharmacological tool to study signal transduction pathways, tyrosine phosphorylation and to induce apoptosis.
May participate in antigen-induced T-cell activation;
Affects Proto-oncogene serine/threonine-protein kinase Pim-1, T-cell-specific kinase, Tyrosine-protein kinase SYK, MAP kinase-activated protein kinase 2

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Supply related information

Shipped at ambient temperature

Shipped in PP / PE bottle.

Special Info

Available since

1998

Other Fields

Title

Transport information

Value

Not hazardous for transport

Title

Deleted CAS numbers

Value

109189-95-9

Title

Safety comments

Value

Others say it is cancerogen, explosive. We think, because theirs contains ligroyin.

Title

identity comments

Value

HCl salt thereof: C28-H26-N4-O3.Cl-H ; RTECS KD5084000;

Fermentek Product Category

Enzyme-inhibitors

Protein kinase related

Anti Fungal

Research field: Signal Transduction

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Signal to sort

Patulin

Molecular Formula

C7H6O4

M.W.

154.10

CAS number

149-29-1

MSDS

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Details

Source

Penicillium expansum

Fermentek product Code

PAT-001

Brand/grade

For research

Specifications

Appearance

White crystalline solid.

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

105°C-113°C

Solubility test

Clear colorless solution at 10mg/ml DMSO

Chemical identification

Names and identifiers

Synonyms:

Clavacin
Claviformin
Mycoin
Penicidin
Expansin
Leucopin
Gigantin

IUPAC name: 4-hydroxy-4H-furo[3,2-c]pyran-2(6H)-one

HSDB: 3522

RTECS#: LV2625000

EU number

205-735-2

Description

Patulin: a cytostatic, antibacterial mycotoxin. Inhibits potassium uptake, activates the p38 kinase.

InChl Key

ZRWPUFFVAOMMNM-UHFFFAOYSA-N

Canonical SMILES

C1C=C2C(=CC(=O)O2)C(O1)O

Further Information

Solubility ( literature )

Patulin is soluble in DMSO, Methanol, Ethanol, water

Compound Classification

Lactone Mycotoxin
Cell signaling reagent;
apopotosis inducer

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from light !

Retest time

3 Years

Applications

Patulin was suggested as a remedy against common cold and reached clinical trials step in 1943 in Great Britain. However Patulin was found to be inefficient as such.(International Journal of Epidemiology 2004;33:243–246)

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

1999

Other Fields

Title

Transport information

Value

Pg II

Fermentek Product Category

Mycotoxins

Research field: Signal Transduction

Read more about Patulin

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Mitomycin C

Molecular Formula

C15H18N4O5

M.W.

334.30

CAS number

50-07-7

MSDS

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Details

Source

Streptomyces caespitous

Fermentek product Code

MTC-001

Brand/grade

For research

Specifications

Appearance

Blue-violet solid

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear blue-violet solution at 10mg/ml Methanol

Chemical identification

Names and identifiers

Synonyms:

mutamycin
ametycin,
mitocin-C,

IUPAC name:
{11-Amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0^2,7.0^4,6]trideca-1(9),11-dien-8-yl}methyl carbamate

RTECS: CN0700000

EU number

200-008-6

Description

Mitomycin C is an anti-tumor antibiotic that binds covalently to DNA.

Mitomycin C has also antibacterial properties.

InChl Key

NWIBSHFKIJFRCO-WUDYKRTCSA-N

Canonical SMILES

CC1=C(C(=O)C2=C(C1=O)N3CC4C(C3(C2COC(=O)N)OC)N4)N

Isomeric SMILES

CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)N

Further Information

Solubility ( literature )

Soluble is Methanol; Soluble in water.

Compound Classification

Indolequinone antibiotic.

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Keep the lid tightly closed.

Other vendors may recommend storage at 4ºC

Retest time

3 Years

Applications

Mitomycin C is also available as a a 4% mixture in NaCL. See "Mitomycin C+NaCL" Sample CoA

Disclaimer

For Research use only

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2000

Other Fields

Fermentek Product Category

Read more about Mitomycin C

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Geldanamycin

Molecular Formula

C29H40N2O9

M.W.

560.60

CAS number

30562-34-6

MSDS

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Details

Source

Streptomyces Hygroscopicus var Geldanus

Fermentek product Code

GEL-001

Brand/grade

For research

Specifications

Appearance

Yellow solid

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

Single spot on TLC plates, by multiple methods.

Melting point

260°C-268°C

Crystallinity

Amorphous

Solubility test

Clear yellow solution at 10 mg/ml in DMSO ; Clear yellow solution at 5 mg/ml in Dichloromethane

Chemical identification

Names and identifiers

RTECS LX8920000

IUPAC Name : [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate I

Description

Geldanamycin is a benzoquinone ansamycin antibiotic, which binds to Hsp90 (Heat Shock Protein 90) and alters its function. Geldanamycin is a natural product from which several valuable derivates were synthesized. All derivates share its HSP90 inhibition, and vary in overall toxicity and water solubility.

InChl Key

QTQAWLPCGQOSGP-KSRBKZBZSA-N

Canonical SMILES

CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC

Isomeric SMILES

C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)\C)C)O)OC

Further Information

Solubility ( literature )

Geldanamycin is soluble in DMSO, Dichloromethane. Geldanamycin is insoluble in water.

Compound Classification

Benzoquinone ansamycin antibiotic ;

HSP90 inhibitor ;

Tyrosine Kinase Inhibitor ;

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Use the original container to store the product.

Avoid exposing to strong direct light.

Retest time

3 Years

Applications

Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

2002

Other Fields

Title

Transport information

Value

Not hazardous for transport

Title

Research fields

Value

Cancer

Fermentek Product Category

HSP90 inhibitors

Research Area: Stem Cells

Read more about Geldanamycin

Signal to sort

Cytochalasin D

Molecular Formula

C30H37NO6

M.W.

507.62

CAS number

22144-77-0

MSDS

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Details

Source

Zygosporium mansonii

Fermentek product Code

CYD-001

Brand/grade

For research

Specifications

Appearance

White powder

Purity by HPLC

≥97% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

230°C-245°C

Solubility test

Clear colorless solution at 25mg/ml DMSO, Clear colorless solution at 5mg/ml Ethanol

Chemical identification

Names and identifiers

Synonyms: Zygosporin A

Chemical Name: (7S,13E,16S,18R,19E,21R)-21-(Acetyloxy)- 7,18-dihydroxy-16,18-dimethyl-10-phenyl[11]cytochalasa-6(12),13,19-triene-1,17-dione

EU number

244-804-1

Description

Cytochalasin D is a cell permeable mycotoxin, which causes both the association and dissociation of actin subunits. Cytochalasin D disrupts actin filaments and inhibits actin polymerization.

InChl Key

SDZRWUKZFQQKKV-JHADDHBZSA-N

Canonical SMILES

CC1CC=CC2C(C(=C)C(C3C2(C(C=CC(C1=O)(C)O)OC(=O)C)C(=O)NC3CC4=CC=CC=C4)C)O

Isomeric SMILES

C[C@H]1C/C=C/[C@H]2[C@@H](C(=C)[C@H]([C@@H]3[C@@]2([C@@H](/C=C/[C@@](C1=O)(C)O)OC(=O)C)C(=O)N[C@H]3CC4=CC=CC=C4)C)O

Further Information

Solubility ( literature )

DMSO, Ethanol, Methanol

Compound Classification

Macrolide indol mycotoxin
Cytochalasin
Actin inhibitor

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Protect from moisture

Open carefully.

Use the original container to store the product.

Avoid exposing to strong direct light.

Store under argon.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Cytochalasins are used as tools in cytological research, and in the field of actin polymerization. Cytochalasin D is 10 times more effective than cytochalasin B and does not inhibit glucose transport across cell membranes.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

1998

Other Fields

Title

Deleted CAS Numbers

Value

11032-97-6 ; 25852-72-6 ; 28455-04-1 ; 69401-32-7

Title

TSE

Value

Title

sig

Value

250255

Fermentek Product Category

Read more about Cytochalasin D

Signal to sort

Chromomycin A3

Molecular Formula

C57H82O26

M.W.

1 183.25

CAS number

7059-24-7

Details

Source

Streptomyces griseus

Fermentek product Code

CHR-001

Brand/grade

For research

Specifications

Appearance

Yellow powder

Purity by HPLC

≥97% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Melting point

180°C-192°C

Solubility test

Clear yellow solution at 10mg/ml of Ethyl Acetate

Chemical identification

Names and identifiers

Synonyms:

Olivomycin D
Toyomycin

IUPAC name:

(1S)-1-C-((2S,3S)-7-{[4-O-acetyl-2,6-dideoxy-3-O-(2,6-dideoxy-4-O-methyl-α-D-lyxo-hexopyranosyl)-β-D-lyxo-hexopyranosyl]oxy}-3-{[4-O-acetyl-2,6-dideoxy-3-C-methyl-α-L-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl-(1→3)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy}-5,10-dihydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl)-5-deoxy-1-O-methyl-D-xylulose

RTECS GB7875000

EU number

230-348-0

Chemical name

Chromomycin A3

Description

Chromomycin A3 is an antibiotic of the Anthraquinone group. It inhibits RNA synthesis by interfering with the binding of the transcription factors Sp1 and Sp3 to the DNA. Chromomycin A3 exhibits anti-bacterial, anti-fungal and antitumor activitie. Chromomycin A3 gains interest as a candidate anticancer drug. is also used as a fluorescent dye to determine DNA concentrations.

InChl Key

ZYVSOIYQKUDENJ-WKSBCEQHSA-N

Canonical SMILES

CC1C(C(CC(O1)OC2C(CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)OC5CC(C(C(O5)C)OC(=O)C)OC6CC(C(C(O6)C)OC)O)O)C(C(=O)C(C(C)O)O)OC)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)OC(=O)C)(C)O)O

Isomeric SMILES

C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@H]2[C@@H](CC3=C(C2=O)C(=C4C(=C3)C=C(C(=C4O)C)O[C@H]5C[C@H]([C@H]([C@H](O5)C)OC(=O)C)O[C@@H]6C[C@H]([C@H]([C@H](O6)C)OC)O)O)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]7C[C@H]([C@@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@H]([C@@H](O8)C)OC(=O)C)(C)O)O

Further Information

Solubility ( literature )

DMSO, Ethyl Acetate, Methanol, Ethanol

Compound Classification

Glycosidic antibiotic

Storage, handling

Store in a freezer upon arrival, at -10°C to -25°C

Open carefully.

Avoid exposing to strong direct light.

Store under argon.

Other vendors may recommend higher temperatures for storage.

Retest time

3 Years

Applications

Membrane-impermeant, G/C-specific fluorescent DNA-binding dye.
Antibacterial antibiotic.
Antitumor antibiotic that inhibits RNA synthesis, especially in solid tumors.

Disclaimer

For Research use only

Not for Human or Drug use

Not extracted from humans or animals

Refer to MSDS for further safety and handling instructions

Composition

Ingredient type

Fermentek product

Special Info

Available since

1998

Other Fields

Title

Transport information

Value

PG I

Title

TSE

Value

Title

sig

Value

230752

Fermentek Product Category

Anti Fungal

Anti Bacterial