Antibiotics are antimicrobial compounds used in the treatment and prevention of bacterial infection. They can either kill or they can inhibit the growth of bacteria. Several antibiotics are also effective against fungi and protozoans. Some are toxic to humans and animals, even when given in therapeutic dosages. Antibacterial antibiotics are commonly classified based on their mechanism of action, chemical structure, or spectrum of activity. Most antibiotics target bacterial metabolic functions or growth processes. Those antibiotics that interfere with the function of essential bacterial enzymes, or that target the bacterial cell wall or the cell membrane, are usually bactericidal. Those that target protein synthesis are usually bacteriostatic. Further categorizations can be made based on target specificity. Use of antibiotics is essential in retaining the purity of particular selection factors in populations of cells. In recent years antibiotics have been found to be valuable in a wide range of life science disciplines. Fermentek has had particular success in manufacturing antibiotics using fermentation processes.

KT5720

KT5720
Molecular Formula
C32H31N3O5
CAS number
108068-98-0
MSDS
Source
Semisynthetic
Fermentek product Code
KT5-001
Brand/grade
For research
Appearance
White to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml Methanol
EU number
810-587-2
Description

KT5720: A selective inhibitor of cAMP-dependent protein kinase (PKA)

InChl Key
ZHEHVZXPFVXKEY-UHFFFAOYSA-N
Canonical SMILES
CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
Isomeric SMILES
CCCCCCOC(=O)[C@]1(C[C@H]2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)[C@@]1(O2)C)CNC6=O)O
Solubility ( literature )

Soluble in methanol, DMSO

Compound Classification

indolocarbazole alkaloid

PKA inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
KT5720.gif
KT5720.gif

K252c

K252c
Molecular Formula
C20H13N3O
M.W.
311.40
CAS number
85753-43-1
Source
Nocardiopsis sp
Fermentek product Code
K2C-001
Brand/grade
For research
Appearance
Off-white to yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to light yellow solution at 7.8mg/ml DMSO (25mM)
Names and identifiers

Synonyms:

  • Staurosporine aglycone;
  • Staurosporinone.
  • K252C

 

Description

K252c: Cell permeable protein kinase inhibitor of the Staurosporine family (indolo[2,3-a]carbazole alkaloids)

InChl Key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
Canonical SMILES
C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;Soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol. Comment: This information has been collected from available scientific sources. It is not a part of product specification

Compound Classification

indolocarbazole alkaloidPKC inhibitor

Storage, handling
-20oC. Protect from light. Hygroscopic. Protect from moisture
Retest time
3 Years
Applications

K252c inhibits protein kinase C. Its reported IC50 value of 214 nM on rat brain enzyme K252c is cytotoxic for A549 and P388 cancer celllines showing IC50 = 2-3 μM

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
K252c.gif
K252c.gif

K252b

K252b
Molecular Formula
C26H19N3O5
M.W.
453.45
CAS number
99570-78-2
Source
Semisynthetic
Fermentek product Code
K2B-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml of Methanol
Names and identifiers

Synonyms:

  • Antibiotic K 252b
  • K 252b
  • KT 5556

 

 

 

Description

K252B: an inhibitor of protein kinase A, C, G

InChl Key
AMSOPBXQXSAAAC-PLZPTFKGSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Solubility ( literature )

DMSO or Methanol

Compound Classification

Indolocarbazole alkaloid; 

PK inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
107028-51-3
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
K252b.gif
K252b.gif

K252a

K252a
Molecular Formula
C27H21N3O5
M.W.
467.47
CAS number
99533-80-9
Source
Nocardiopsis sp
Fermentek product Code
K2A-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to slight yellow solution at 50mg/ml of DMSO
Names and identifiers

RTECS NZ0550000

EU number
640-127-4
Description

K252a: Cell permeable protein kinase inhibitor

InChl Key
KOZFSFOOLUUIGY-IYYJOCMQSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Isomeric SMILES
C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Compound Classification
  • indolocarbazole alkaloid
  • PK inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase . At high concentrations it also inhibitors of serine/threonine protein kinases. K252a inhibits tyrosine phosphorylation of Trk A induced by NGF K252a is reported to promote myogenic differentiation in C2 mouse myoblasts

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
97161-97-2; 105450-17-7; 108645-76-7; 151004-74-9
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

Quote for

Price
$1.00
K252a.gif
K252a.gif

Ionomycin free acid

Ionomycin free acid
Molecular Formula
C41H72O9
M.W.
709.01
CAS number
56092-81-0
MSDS
Source
Streptomyces conglobatus
Fermentek product Code
IOF-001
Appearance
Waxy material
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol; Clear colorless solution at 10mg/ml of DMSO; Clear colorless solution at 10mg/ml of DCM
Names and identifiers

(4R,6S,8S,10Z,12R,14R,16E,18S,19S,20R,21S)-11,19,21-Trihydroxy-22-{(2S,2'S,5S,5'R)-5'-[(1S)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-9-oxo-10,16-docosadi enoic acid

RTECS : NO0600000

EU number
611-356-7
Description

Ionomycin : a Ca++ ionophore

InChl Key
PGHMRUGBZOYCAA-ADZNBVRBSA-N
Canonical SMILES
CC(CCC(=O)O)CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)O
Isomeric SMILES
C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\O
Solubility ( literature )

DMSO, Ethanol, Methanol

Compound Classification
  • Unsaturated fatty acid antibiotic.
  • Calcium Ionophore
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Ionomycin is more effective than A23187 as a Ca++ionophore. Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neuron

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport safety information
Value
Nor hazardous goods
Fermentek Product Category
Antibiotics
Ionophores
Signal to sort
I

Quote for

Price
$1.00
Ionomycin_free_acid.gif
Ionomycin_free_acid.gif

Ionomycin Calcium Salt

Ionomycin Calcium Salt
Molecular Formula
C41H70O9Ca
M.W.
747.06
CAS number
56092-82-1
MSDS
Source
Streptomyces conglobatus
Fermentek product Code
IOC-001
Brand/grade
For research
Appearance
White to slight yellow powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml DMSO,
Clear colorless solution at 10mg/ml Methanol
Names and identifiers

RTECS NO0650000

EU number
611-357-2
Description

Ionomycin : a potent and selective Ca++ ionophore

InChl Key
WKRWUYKLUMMAKG-UHFFFAOYSA-L
Canonical SMILES
CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC(C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)[O-].[Ca+2]
Solubility ( literature )

DMSO, Ethanol, Methanol

Compound Classification
  • Fatty acid antibiotic
  • Calcium Ionophore
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Ionomycin is more effective than A23187 as a Ca++ionophore. Ionomycin is used in research on Ca++ transport across biological membranes; Ionomycin induces apoptotic degeneration of embryonic cortical neurons.

Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
Transport information
Value
Not dangerous goods
Title
Deleted CAS Numbers
Value
1214981-98-2
Fermentek Product Category
Antibiotics
Apoptosis related
Immunomodulators
Ionophores
Signal to sort
I

Quote for

Price
$1.00
Ionomycin_Ca_salt.gif
Ionomycin_Ca_salt.gif

Genistein

Genistein
Molecular Formula
C15H10O5
M.W.
270.20
CAS number
446-72-0
Source
Soy bean (plant extract)
Fermentek product Code
GEN-001
Brand/grade
For research
Appearance
White solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 50mg/ml DMSO
Names and identifiers

Synonyms: 4′,5,7-Trihydroxyisoflavone

RTECS: NR2392000

 

EU number
207-174-9
Description

Genistein: an isoflavone with anticancer, antiproliferation, and chemopreventive effects. Genistein induces cell differentiation. Genistein inhibits protein histidine kinase.

InChl Key
TZBJGXHYKVUXJN-UHFFFAOYSA-N
Canonical SMILES
C1=CC(=CC=C1C2=COC3=CC(=CC(=C3C2=O)O)O)O
Solubility ( literature )

Genistein is soluble in DMSO, Ethanol.

Compound Classification

isoflavonoid

histidine kinase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Antibiotics
Research field: Cancer
Signal to sort
G

Quote for

Price
$1.00
Genistein.gif
Genistein.gif

Geldanamycin

Geldanamycin
Molecular Formula
C29H40N2O9
M.W.
560.60
CAS number
30562-34-6
MSDS
Source
Streptomyces Hygroscopicus var Geldanus
Fermentek product Code
GEL-001
Brand/grade
For research
Appearance
Yellow solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
Single spot on TLC plates, by multiple methods.
Solubility test
Clear yellow solution at 10 mg/ml in DMSO ; Clear yellow solution at 5 mg/ml in Dichloromethane
Names and identifiers

RTECS LX8920000

IUPAC Name : [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11,21-trimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate I

Description

Geldanamycin is a benzoquinone ansamycin antibiotic, which binds to Hsp90 (Heat Shock Protein 90) and alters its function. Geldanamycin is a natural product from which several valuable derivates were synthesized. All derivates share its HSP90 inhibition, and vary in overall toxicity and water solubility.

InChl Key
QTQAWLPCGQOSGP-KSRBKZBZSA-N
Canonical SMILES
CC1CC(C(C(C=C(C(C(C=CC=C(C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)C)OC)OC(=O)N)C)C)O)OC
Isomeric SMILES
C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)OC)/C)OC)OC(=O)N)\C)C)O)OC
Solubility ( literature )

Geldanamycin is soluble in DMSO, Dichloromethane. Geldanamycin is insoluble in water.

Compound Classification

Benzoquinone ansamycin antibiotic ;

 

HSP90 inhibitor ;

Tyrosine Kinase Inhibitor ;

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Exhibits potent antitumor activity. It also inhibits nuclear hormone receptors.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
Research fields
Value
Cancer
Fermentek Product Category
Antibiotics
Research field: Cancer
HSP90 inhibitors
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Signal to sort
G

Quote for

Price
$1.00
Geldanamycin.gif
Geldanamycin.gif

Forskolin

Forskolin
Molecular Formula
C22H34O7
M.W.
410.50
CAS number
66575-29-9
MSDS
Source
Coleus forskohlii (plant extract)
Fermentek product Code
FOR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml EtOAc
Names and identifiers

Synonyms :

Boforsin; Colforsin; Coleonol

RTECS QL6150000

EU number
266-410-9
Description

Forskolin is a labdane diterpene that is produced by Coleus forskohlii

InChl Key
OHCQJHSOBUTRHG-KGGHGJDLSA-N
Canonical SMILES
CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)O
Isomeric SMILES
CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
Solubility ( literature )

Forskolin is soluble in DMSO, Methanol, Ethanol, Dichloromethane, Forskolin may be dissolved in 2% ethanol in water, by dissolving it first in Ethanol and subsequently diluting this solution with water.

Compound Classification
  • diterpene antibiotic
  • vasodilator
Storage, handling
Room temperature or below. Light protection is recommended by other sources.
Retest time
3 Years
Applications
  • Bronchodilator agent,  Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
  • Cardiotonic agent: Agents that have a strengthening effect on the heart or that can increase cardiac output. 
  • Vasodilator agent: Agent   causing dilation of the blood vessels.
  • Forskolin activates Adenylate Cyclase, thus increasing the cyclic AMP intra-cellular concentration. Forskolin is commonly used to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology. Forskolin has been mentioned as a possible weight loss aid, and as a mean to treat Glaucoma, as it may reduce the intraocular pressure. See also United States Patent Application 20100168014
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Plant-derived
Antibiotics
Vasodilator Agents
Signal to sort
F

Quote for

Price
$1.00
Forskolin.gif
Forskolin.gif

FK-506 (Tacrolimus)

FK-506 (Tacrolimus)
Molecular Formula
C44H69NO12
M.W.
804.02
CAS number
104987-11-3
MSDS
Source
Streptomyces sp.
Fermentek product Code
FK5-001
Brand/grade
For research
Appearance
White to off white powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml Ethyl acetate or DMSO
Names and identifiers

Synonyms: FK506, Tacrolimus,

RTECS:       KD4200000

EU number
658-056-2
Chemical name
FK506
Description

FK506 is 23-membered macrolide lactone discovered in 1984, by Kino T, Hatanaka H and Hashimoto M. [reference 2] FK506 exhibits potent inhibitory effect on T- lymphocyte activation. It binds to immunophilins FK506 binding proteins (FKBP-12) and a complex of FKBP-12, calcium, calmodulin and calcineurin is formed, inhibiting phosphatase activity of calcineurin. This prevents dephosphorylation and translocation of nuclear factor of activated T – cells (NF-AT) and inhibits transcription of early T-cell activation gene, Interleukin-2, Tumour Necrosis Factor (TNF-a) and proto-oncogenes; suppressing expression of IL-2 and IL-7 receptor. This results in inhibition of T-lymphocyte activation. FK506 also inhibits the mixed lymphocyte reaction, generation of cytotoxic T-cells and T-cell dependent B-cell activation.

InChl Key
QJJXYPPXXYFBGM-LFZNUXCKSA-N
Canonical SMILES
CC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC
Isomeric SMILES
C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
Solubility ( literature )

FK506 is soluble in Methanol, Ethanol, Acetone, Ethyl Acetate, Diethyl ether, Chloroform, Dicloromethane. FK506 is sparingly soluble in Hexane, Petroleum ether. FK506 is insoluble in water

Compound Classification

Chemical classification:

Macrolide

Bioactivity classification

Immunosuppressant

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Applications

FK506 (Tacrolimus) is used as an immunosuppressant at organ transplantations. For experimental uses of FK506 (Tacrolimus) read also United States Patent Application 20090098200

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
toxicity by RTECS
Value
>200mg/kg oral mouse
Fermentek Product Category
Antibiotics
Immunosupressors
Immunomodulators
Signal to sort
F

Quote for

Price
$1.00
FK_506.gif
FK_506.gif
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