K252c

Molecular Formula

C20H13N3O

M.W.

311.40

CAS number

85753-43-1

Details

Source

Nocardiopsis sp

Fermentek product Code

K2C-001

Brand/grade

For research

Specifications

Appearance

Off-white to yellow powder

Purity by HPLC

≥98% ; refer to CoA for more data

Purity By TLC

≥98% ; refer to CoA for more data

Solubility test

Clear colorless to light yellow solution at 7.8mg/ml DMSO (25mM)

Chemical identification

Names and identifiers

Synonyms:

Staurosporine aglycone;
Staurosporinone.
K252C

Description

K252c: Cell permeable protein kinase inhibitor of the Staurosporine family (indolo[2,3-a]carbazole alkaloids)

InChl Key

MEXUTNIFSHFQRG-UHFFFAOYSA-N

Canonical SMILES

C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5

Further Information

Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;Soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol. Comment: This information has been collected from available scientific sources. It is not a part of product specification

Compound Classification

indolocarbazole alkaloidPKC inhibitor

Storage, handling

-20oC. Protect from light. Hygroscopic. Protect from moisture

Retest time

3 Years

Applications

K252c inhibits protein kinase C. Its reported IC50 value of 214 nM on rat brain enzyme K252c is cytotoxic for A549 and P388 cancer celllines showing IC50 = 2-3 μM

Composition

Ingredient type

Fermentek product

Special Info

Available since

2011