Cancer is most accurately described as a class of diseases characterized by uncontrolled cell growth and division.There are more than a hundred defined types of cancer.

Cancer can occur in nearly every organ or tissue in the body.

Various small molecules are widely used in the research of cancer. Especially in the last decade, cancer research has evolved from a one-size-fits-all approach that emphasized cytotoxic chemotherapy to a more personalized medical strategy that focuses on the discovery and development of targeted drugs.

These drugs are designed, on a molecular level, to exploit particular genetic dependencies, addictions, and vulnerabilities of cancer cells.

Much current cancer research is concentrated in the areas of programmed cell death, tumor invasion and angiogenesis, tumor immunology, oncogenic signaling, gene expression and copy number, epigenetic regulation, toxicity and chemoresistance, metabolic stress and damage to DNA. Fermentek offers more than 30 unique biochemicals currently being used in cancer research.

Triptolide

Triptolide
Molecular Formula
C20H24O6
M.W.
360.40
CAS number
38748-32-2
Source
Tripterygium wilfordii
Fermentek product Code
TRP-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
223°C-230°C
Solubility test
Clear colorless solution at 10mg/ml of Acetonitrile
Names and identifiers

Synonyms:

  • NSC 163062
  • PG490

Chemical names:
Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

IUPAC: 
(1S,2S,4S,5S,7R,8R,9S,11S,13S)-8-hydroxy-1-methyl-7-(propan-2-yl)-3,6,10,16-tetraoxaheptacyclo[11.7.0.0^{2,4}.0^{2,9}.0^{5,7}.0^{9,11}.0^{14,18}]icos-14(18)-en-17-one

RTECS#: YK7751000

EU number
683-214-2
Chemical name
Triptolide
Description

Triptolide is a diterpenoid epoxide which is produced by Tripterygium wilfordii, a vine used in traditional Chinese medicine. Triptolide has pharmacological activities including anti-inflammatory, immune-supressing, antiproliferative anti-angiogenetic, and proapoptotic activity. It has in vitro and in vivo activities against mouse models of polycystic kidney disease and pancreatic cancer.

InChl Key
DFBIRQPKNDILPW-CIVMWXNOSA-N
Canonical SMILES
CC(C)C12C(O1)C3C4(O3)C5(CCC6=C(C5CC7C4(C2O)O7)COC6=O)C
Isomeric SMILES
CC(C)[C@@]12[C@@H](O1)[C@H]3[C@@]4(O3)[C@]5(CCC6=C([C@@H]5C[C@H]7[C@]4([C@@H]2O)O7)COC6=O)C
Solubility ( literature )

Reportedly: Insoluble in water. Insoluble in Ethanol. Soluble up to 0.2Molar ( 72 mg/ml) of DMSO

Compound Classification

Chemical classification:  Terpenoid

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Shipped in PP / PE bottle.
Available since
Title
Transport safety
Value
NDG
Title
solubility
Value
mrck DMSO (20 mg/ml); others: 0.2 molar in DMSO
Title
source comment
Value
From plant
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Apoptosis related
Cancer Related Compounds
Anti Tumor agents
Immunosupressors
Signal to sort
T

Quote for

Price
$100.00

Ophiobolin B

Ophiobolin B
Molecular Formula
C25H38O4
M.W.
402.57
CAS number
5601-74-1
Source
Cochliobolus heterostrophus
Fermentek product Code
OPB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
179°C-185°C
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Ophiobolin B
  • Ophiobola-7,19-dien-25-al, 3,14-dihydroxy-5-oxo- 
  • Cochliobolin B
  • Zizanin B

IUPAC:

  •  (7E)-3,14-Dihydroxy-5-oxoophiobola-7,19-dien-25-al

RTECS# : 

Chemical name
Ophiobolin B
Description

Sesterterpene, natural inhibitor of Calmodulin, exhibiting anti-cancer, antibacterial properties. Phytotoxin from a plant pathogen.

InChl Key
CC(CCC=C(C)C)C1(CCC2(C1CC=C(C3C(C2)C(CC3=O)(C)O)C=O)C)O
Canonical SMILES
CC1CC(OC12CCC3(C2CC=C(C4C(C3)C(CC4=O)(C)O)C=O)C)C=C(C)C
Isomeric SMILES
C[C@@H](CCC=C(C)C)[C@]1(CC[C@]2([C@H]1C/C=C(\[C@@H]3[C@H](C2)[C@](CC3=O)(C)O)/C=O)C)O
Solubility ( literature )

Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: not regulated.
Available since
Title
inhibitor-of
Value
CalModulin (calcium-modulated protein)
Title
Harmonized code (38220090 Diagnostic or laboratory reagents, CRM)
Value
38220090
Title
Deleted CAS Registry Numbers
Value
7072-88-0;11022-23-4;17046-66-1;
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Others
Signal to sort
O

Quote for

Price
$50.00

Bafilomycin B1

Bafilomycin B1
Molecular Formula
C44H65NO13
M.W.
816.00
CAS number
88899-56-3
Source
Streptomyces sp.
Fermentek product Code
BFB-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear yellow solution at 5mg/ml Methanol ;
Clear yellow solution at 5mg/ml DMSO ;
Names and identifiers

Synonyms

  • Hygrolidin, 37-decarboxy-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methyl
  • Setamycin
  • Bafilomycin B1

IUPAC Name

  • (5R)-2,4-Dideoxy-1-C-{(2S,3R,4S)-3-hydroxy-4-[(3S,4Z,9S,10S,11R)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-2-pentanyl}-3-O-{(2E)-4-[(2-hydroxy-5-ox ;o-1-cyclopenten-1-yl)amino]-4-oxo-2-butenoyl}-5-isopropyl-4-methyl-α-D-threo-pentopyranose

 RTECS: NG8841000

EU number
635-481-1
Chemical name
Bafilomycin B1
Description

Bafilomycin B1 is a specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms.

Bafilomycin B1  can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

It displays Antibacterial, Antifungal, Antineoplastic, Immunosuppressive properties.

Bafilomycin B1 shares the same mode of action and activity as its more accessible Bafilomycin A1 analogue. Bafilomycin B1 is broadly active against bacteria, fungi, insects, nematodes and protozoans. Bafilomycin B1 has attracted interest as a potential antiosteoporotic agent in treating bone lytic diseases.

Bafilomycins have been considered as possible therapeutic agents in the treatment of gastritis.

InChl Key
KFUFLYSBMNNJTF-MZYUNMTESA-N
Canonical SMILES
CC1CC(=CC=CC(C(OC(=O)C(=CC(=CC(C1O)C)C)OC)C(C)C(C(C)C2(CC(C(C(O2)C(C)C)C)OC(=O)C=CC(=O)NC3=C(CCC3=O)O)O)O)OC)C
Isomeric SMILES
C[C@H]1C/C(=C\C=C/[C@@H](C(OC(=O)/C(=C\C(=C/[C@H]([C@H]1O)C)\C)/OC)[C@@H](C)[C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)C(C)C)C)OC(=O)/C=C/C(=O)NC3=C(CCC3=O)O)O)O)OC)/C
Solubility ( literature )

Reportedly soluble in ethanol, methanol, DMF or DMSO. Attention: may form methyl ketal on long term storage in methanol

Compound Classification

Macrolide antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Store under argon.
shipped at ambient temperature. Stored under inert atmosphere.
Retest time
1.5 Years
Applications

Bafilomycins specificly  inhibit  vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms. Bafilomycin A1 is useful in distinguishing among different types of ATPases. Bafilomycin A1 can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis. Bafilomycin A1 and B1 significantly attenuate cerebellar granule neuron death resulting from agents that disrupt lysosome. As vacuolar ATPase inhibitors bafilomycins overcome Bcl-​xL-​mediated chemoresistance through restoration of a caspase-​independent apoptotic pathway.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
II or III but basic information is not credible, no quantitative data available
Title
Deleted CAS Numbers
Value
80112-34-1; used with name Setamycin only
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Anti Parasitic
Anti Bacterial
Cancer Related Compounds
Immunomodulators
Research area: Multi-drug resistance
Signal to sort
B

Quote for

Price
$100.00

Phomopsin A

Phomopsin A
Molecular Formula
C36H45ClN6O12
M.W.
789.20
CAS number
64925-80-0
Source
Phomopsis leptostromiformis
Fermentek product Code
PHA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO ;
Clear colorless solution at 5 mg/ml of Methanol
Names and identifiers

IUPAC:  (2E)-2-{[(2E)-2-({[(2S)-1-{[(3R,4S,7S,10S,11S)-14-Chloro-3-ethyl-11,15-dihydroxy-7-isopropenyl-3-methyl-10-(methylamino)-6,9-dioxo-2-oxa-5,8-diazabicyclo[10.3.1]hexadeca-1(16),12,14-trien-4-yl]carbony l}-2,5-dihydro-1H-pyrrol-2-yl]carbonyl}amino)-3-methyl-2-pentenoyl]amino}-2-butenedioic acid

RTECS# SY2593000

Chemical name
Phomopsin A
Description

Cyclic hexapeptide antibiotic. Phomopsin A exhibits very strong inhibitory properties of microtubule assembly. It binds to tubulin at a site different from the colchicine binding site.

InChl Key
FAFRRYBYQKPKSY-AJSRVUJESA-N
Canonical SMILES
CCC(=C(C(=O)NC(=CC(=O)O)C(=O)O)NC(=O)C1C=CCN1C(=O)C2C(OC3=C(C(=CC(=C3)C(C(C(=O)NC(C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)C
Isomeric SMILES
CC/C(=C(\C(=O)N/C(=C/C(=O)O)/C(=O)O)/NC(=O)[C@@H]1C=CCN1C(=O)[C@@H]2[C@@](OC3=C(C(=CC(=C3)[C@@H]([C@@H](C(=O)N[C@H](C(=O)N2)C(=C)C)NC)O)Cl)O)(C)CC)/C
Solubility ( literature )

Soluble in Ethanol, Methanol, DMSO and DMF. Sparingly siluble in water. Not stable in watery solutions. (lit).

Compound Classification

Classification by Bioactivity

  • Agent that interacts with TUBULIN to inhibit or promote polymerization of MICROTUBULES
  • A potent microtubule inhibitor

Chemical Classification

  • Hexapeptide
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Expiration time
3Y
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
126061-16-3
Title
Transport safety
Value
NDG
Title
EC registration
Value
not EC, validated 2-Apr-19
Fermentek Product Category
Mycotoxins
Research field: Cancer
Protein kinase related
Microtubuli assembly inhibitors
Anti Mitotic
Anti Fungal
Anti Bacterial
Cyclic hexapeptide antibiotic
Research field: Immunology
Research field: Inflamation
Signal to sort
P

Quote for

Price
$1.00

Cercosporin

Cercosporin
Molecular Formula
C29H26O10
M.W.
534.51
CAS number
35082-49-6
MSDS
Source
Cercospora kikuchii
Fermentek product Code
CRS-001
Brand/grade
For research
Appearance
Dark red powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear red solution at 10mg/ml of DMSO, Clear red solution at 10mg/ml of Methanol
Names and identifiers

Synonyms:

  • Isocercosporin
  • Cercosporin

IUPAC:  5,12-Dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxyperylo[1,12-def][1,3]dioxepine-6,11-dione 

Chemical names:

RTECS#:  N.A.

EU number
n.a.
Description

Cercosporin is a light-induced polyketide phytotoxin reported to produce singlet oxygen when photoactivated. Acts as a potent and specific PKC inhibitor. Competes for the phorbol binding site. Anticancer compound. Also displays antiproliferative; antiparasitic and antimicrobial properties. Cercosporin is a photosensitizing toxin produced by fungal plant pathogens in the genus Cercospora. Cercosporin produces singlet oxygen and superoxide when irradiated by light, and damages plants by causing a peroxidation of the membrane lipids. This membrane damage leads to a loss in membrane fluidity, leakage of nutrients, and rapid death of the plant cell. Cercosporin is toxic to mice and bacteria in addition to plants, and attempts to select plant cells in vitro for resistance to cercosporin have not been successful. A large number of fungal species, however, are resistant to cercosporin. Carotenoids and the fungal cell wall appear to play a critical role in the resistance of fungi to cercosporin.

InChl Key
MXLWQNCWIIZUQT-NFJWQWPMSA-N
Canonical SMILES
CC(CC1=C(C(=C2C(=O)C=C3C4=C5C(=CC(=O)C6=C(C(=C(C(=C56)C1=C42)CC(C)O)OC)O)OCO3)O)OC)O
Isomeric SMILES
C[C@H](CC1=C(C(=C2C(=O)C=C3C4=C5C(=CC(=O)C6=C(C(=C(C(=C56)C1=C42)CC(C)O)OC)O)OCO3)O)OC)O
Solubility ( literature )
  • Soluble in DMSO, ethanol or methanol (lit)
  • Soluble in 1mg/ml ethanol, methanol, DMSO
  • Soluble in 1mg/liter H2O
  • Melting Point: 241℃ lit - Scifinder
Compound Classification
  • Anticancer agent
  • protein kinase C inhibitor

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Transport safety: Not Dangerous Goods; Not Regulated
Available since
Title
MP lit
Value
241°C scifinder; 225-228℃ ; biolinks
Title
LD50 mouse interperitoneal
Value
LD50 >200 mg​/kg i.p. in mice
Title
activity
Value
anticancer agents and protein kinase C inhibitor
Title
comments CAS
Value
There are Cercosporin 35082-49-6 , Iso-Cercosporin 40501-77-7
Title
PG
Value
none. not hazardous.
Fermentek Product Category
Cytotoxic agents
Research field: Cancer
Protein kinase related
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Others
Signal to sort
C

Quote for

Price
$100.00

Ophiobolin A

Ophiobolin A
Molecular Formula
C25H36O4
M.W.
400.55
CAS number
4611-05-6
Source
Cochliobolus heterostrophus
Fermentek product Code
OPA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
171°C-180°C
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Ophiobola-7,19-dien-25-al, 14,18-epoxy-3-hydroxy-5-oxo-, (18R)- (8CI)
  • Ophiobolin A
  • Cochliobolin
  • Ophiobolin;
  • Cochliobolin A

IUPAC:

  • (7E,18R)-3-Hydroxy-5-oxo-14,18-epoxyophiobola-7,19-dien-25-al

RTECS# : RL1576000.

EU number
636-934-6
Chemical name
Ophiobolin A
Description

Sesterterpene, natural inhibitor of Calmodulin, exhibiting anti-cancer, antibacterial properties. Phytotoxin from a plant pathogen.

InChl Key
MWYYLZRWWNBROW-BDZRSQQBSA-N
Canonical SMILES
CC1CC(OC12CCC3(C2CC=C(C4C(C3)C(CC4=O)(C)O)C=O)C)C=C(C)C
Isomeric SMILES
C[C@H]1C[C@@H](O[C@@]12CC[C@]3([C@H]2C/C=C(\[C@@H]4[C@H](C3)[C@](CC4=O)(C)O)/C=O)C)C=C(C)C
Solubility ( literature )

Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Store under argon.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped in amber-glass vials
Transport safety: not regulated.
Available since
Title
Deleted CAS numbers
Value
1347-57-5; 5843-70-9; 11022-22-3; 17046-71-8
Title
Toxicity estimation
Value
mouse PO 238mg/kg->category III;
Title
inhibitor-of
Value
CalModulin (calcium-modulated protein
Title
Harmonized code (38220090 Diagnostic or laboratory reagents, CRM)
Value
38220090
Title
Safety:
Value
low PO tox
Title
Transport
Value
Not regulated
Fermentek Product Category
Enzyme-inhibitors
Research field: Cancer
Anti Fungal
Anti Parasitic
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research field: Signal Transduction
Others
Signal to sort
O

Quote for

Price
$75.00

Salinomycin

Salinomycin
Molecular Formula
C42H70O11
M.W.
751.00
CAS number
53003-10-4
MSDS
Source
Streptomyces sp.
Fermentek product Code
SAL-001
Brand/grade
For research
Appearance
White to slightly yellow lyophilizated powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of DMSO
Names and identifiers

Synonyms:

  • Procoxacin
  • Coxistac
  • Antibiotic 61477

Chemical names:

IUPAC:

(2R)-2-{(2R,5S,6R)-6-[(2S,3S,4S,6R)-6-{(2S,5S,7R,9S,10S,12R,15R)-2-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13- en-9-yl}-3-hydroxy-4-methyl-5-oxo-2-octanyl]-5-methyltetrahydro-2H-pyran-2-yl}butanoic acid

RTECS# VO8620000

 
EU number
258-290-1
Chemical name
Salinomycin
Description

A polyether potassium ionophore. Salinomycin is potent antimicrobial, it acts against Gram-positive bacteria, among which there are some hard to treat strains, for example  methicillin-resistant Staphylococcus aureus and methicillin-resistant Staphylococcus epidermidis, and Mycobacterium tuberculosis. 

As an anticancer candidate drug, Salinomycin has been shown by Piyush Gupta et al. of the Massachusetts Institute of Technology and the Broad Institute to kill breast cancer stem cells in mice at least 100 times more effectively than the anti-cancer drug paclitaxel. The study screened 16,000 different chemical compounds and found that only a small subset, including salinomycin and etoposide, targeted cancer stem cells responsible for metastasis and relapse.

 

 

InChl Key
KQXDHUJYNAXLNZ-XQSDOZFQSA-N
Canonical SMILES
CCC(C1CCC(C(O1)C(C)C(C(C)C(=O)C(CC)C2C(CC(C3(O2)C=CC(C4(O3)CCC(O4)(C)C5CCC(C(O5)C)(CC)O)O)C)C)O)C)C(=O)O
Isomeric SMILES
CC[C@H]([C@@H]1[C@H](C[C@H]([C@@]2(O1)C=C[C@H]([C@]3(O2)CC[C@@](O3)(C)[C@H]4CC[C@@]([C@@H](O4)C)(CC)O)O)C)C)C(=O)[C@@H](C)[C@H]([C@H](C)[C@H]5[C@H](CCC(O5)[C@@H](CC)C(=O)O)C)O
Solubility ( literature )

Reported to be soluble in methanol (10 mg/mL)

 

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Open carefully.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

While "For Agriculture" grade of Salinomycin is used as poultry feed additive, Fermentek's "For Research" grade Salinomycin is directed for experimental anti-cancer drugs development. The most prominent property of Salinomycin is to selectively cause apoptosis in Glioblastoma Stem Cells.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
reach
Value
On REACH List of Pre-Registered Substances, March 2009 Registration Date: 31-MAY-2013.
Title
EU Customs Code CN
Value
29419000
Title
Harmonized Tariff Code
Value
294190
Title
general comment
Value
there is Na Salinomycin w cas 55721-31-8
Title
toxicity by RTECS
Value
LD50 oral mouse 50 mg/kg
Title
Deleted CAS Registry Numbers
Value
37362-39-3 ; 50863-72-4
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Protozoal
Anti Bacterial
Cancer Related Compounds
Anti Tumor agents
Research Area: Stem Cells
Ionophores
Signal to sort
S

Quote for

Price
$20.00

Meleagrin

Meleagrin
Molecular Formula
C23H23N5O4
M.W.
433.46
CAS number
71751-77-4
Source
Penicillium chrysogenum
Fermentek product Code
MEG-001
Brand/grade
For research
Appearance
Light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear light yellow solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: 6-O-Methyloxaline

Chemical names:

IUPAC: (3E,7aS,12aR)-6-hydroxy-3-(1H-imidazol-4-ylmethylidene)-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione

RTECS#

Chemical name
Meleagrin
Description

Meleagrin, a fungal alcaloide antibiotic, posesses antitumor and antibiotic activity. Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase.

Meleagrin, CAS 71751-77-4, the fungal alcaloide, should not be confused with the low molecular weight peptide cas 121272-63-7, which is isolated from turkey also called meleagrin.

 

InChl Key
JTJJJLSLKZFEPJ-YVLHZVERSA-N
Canonical SMILES
CC(C)(C=C)C12C=C(C(=O)N3C1(NC(=O)C3=CC4=CN=CN4)N(C5=CC=CC=C25)OC)O
Isomeric SMILES
CC(C)(C=C)[C@]12C=C(C(=O)N\3[C@@]1(NC(=O)/C3=C\C4=CN=CN4)N(C5=CC=CC=C25)OC)O
Solubility ( literature )

Ethanol, methanol, DMF or DMSO. Poor water solubility

Compound Classification

Alcaloide antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Inhibitor of:  Enoyl-[acyl-carrier-protein] reductase [NADH] FabI

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Lot 001 special tests
Value
NMR: complies with structure
Title
Transport information
Value
Not dangerous goods.
Title
Enzyme affected
Value
A Fabl inhibitor
Title
Research fields
Value
Immunology, Inflamation,
Title
madcow category
Value
V=veg fermentation
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Anti Bacterial
Cancer Related Compounds
Signal to sort
M

Quote for

Price
$75.00

Tropodithietic acid (TDA)

Tropodithietic acid (TDA)
Molecular Formula
C8H4O3S2
M.W.
212.25
CAS number
750590-18-2
Source
Phaeobacter gallaeciensis
Fermentek product Code
TDA-001
Brand/grade
For research
Appearance
Orange powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
207°C-213°C
Solubility test
Clear yellow solution at 1 mg/ml of Dichloromethane.
Clear yellow solution at 0.5 mg/ml of Methanol
Names and identifiers

Synonyms:             TDA

Chemical names:   Tropodithietic acid

IUPAC:                    3-Oxo-8,9-dithiabicyclo[5.2.0]nona-1,4,6-triene-2-carboxylic acid

RTECS#                   Not available

 

EU number
806-061-7
Chemical name
Tropodithietic acid
Description

A sulphur containing antibiotic from marine bacteria, responsible for the probiotic proprties of some of these.  Tropodithietic acid It is active against Gram-positive and Gram-negative bacteria, some phytopathogens and mycoplasma. It also has anti-plasmodium activity.

InChl Key
BLFCMITWMARUSM-UHFFFAOYSA-N
Canonical SMILES
C1=CC(=O)C(=C2C(=C1)SS2)C(=O)O
Solubility ( literature )

Soluble in polar organic solvents, such as DMSO, Methanol, Acetone

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Warnings

Warning or harmful

  • Acute toxicity (oral, dermal, inhalation), category 4
  • Skin irritation, categories 2, 3
  • Eye irritation, category 2A
  • Skin sensitization, category 1
  • Specific target organ toxicity following single exposure, category 3
    • Respiratory tract irritation
    • Narcotic effects
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
source
Value
Phaeobacter gallaeciensis
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Protozoal
Anti Bacterial
Signal to sort
T

Quote for

Price
$100.00

Fumitremorgin C

Fumitremorgin C
Molecular Formula
C22H25N3O3
M.W.
379.46
CAS number
118974-02-0
Source
Aspergillus sp.
Fermentek product Code
FUC-001
Brand/grade
For research
Appearance
Crystalline solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C - 271°C
Solubility test
Clear colorless solution at 10mg/ml of
Methanol or Acetonitrile.
Names and identifiers

Synonyms:

Chemical names:

IUPAC:               (5aS,12S,14aS)-9-Methoxy-12-(2-methyl-1-propen-1-yl)-1,2,3,5a,6,11,12,14a-octahydro-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione

RTECS#  UY8709670

EU number
Not listed
Chemical name
Fumitremorgin C
Description

Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has recognized Fumitremorgin C as a potent and specific inhibitor of the breast cancer resistance protein (BCRP/ABCG2) multidrug transporter. It reverses multidrug resistance mediated by BCRP and increases cytotoxicity of several anticancer agents in vitro.

InChl Key
DBEYVIGIPJSTOR-FHWLQOOXSA-N
Canonical SMILES
CC(=CC1C2=C(CC3N1C(=O)C4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
Isomeric SMILES
CC(=C[C@H]1C2=C(C[C@@H]3N1C(=O)[C@@H]4CCCN4C3=O)C5=C(N2)C=C(C=C5)OC)C
Solubility ( literature )

Soluble in Ethanol, Methanol, DMF, DMSO Chloroform.

Negligible solubility ( 35 mg in 1 liter water @25°C) has been reported.

Compound Classification

Breast cancer resistance protein inhibitor

Mammalian cell cycle inhibitors

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous goods. Nor regulated
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Tremorgens
Research field: Cancer
Anti Tumor agents
Research area: Multi-drug resistance
Signal to sort
F

Quote for

Price
$100.00
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