In higher (multicellular) organisms, many processes are required for coordinating individual cells to act as parts of the whole. Among these we may count attraction of spermatozoides by ovum, environment sensing in general, cellular response to hormones and neuro transmitters, initiating and terminating cells multiplication, or imposing apoptosis on unneeded cells during ontogenesis.

Usually, Signal-Transduction would begin with binding of the singnal-molecule to a receptor on the cell-membrane, altering its configuration and thus starting a chain of reactions within the cell. These reactions may include (de)acetylations, (de)/phosphorilations on the participating molcules.

The Signal Transduction related reagents may by further classified as

  • Ca++-ATPase inhibitors, such as Artemisinin, Cyclopiazonic acid, Thapsigargin, Paxilline
  • SERCA Ca2+-ATPase stimulator/ activator, such as Ochratoxin A
  • Hedgehog signalling inhibitors: Cyclopamine

 

Parthenolide

Parthenolide
Molecular Formula
C15H20O3
M.W.
248.32
CAS number
20554-84-1
Source
Tanacetum parthenium
Fermentek product Code
PAR-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
112°C-118°C
Solubility test
Clear colorless solution at 50mg/ml Dichloromethane; Clear colorless solution at 50mg/ml DMSO
Names and identifiers

IUPAC name: (1aR,4E,7aS,10aS,10bS)-1a,5-Dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one

RTECS: LY4220000

EU number
692-532-0
Chemical name
Parthenolide
Description

Parthenolide is a sesquiterpene lactone and active principle of feverfew (Chrysanthemum parthenium)

InChl Key
KTEXNACQROZXEV-PVLRGYAZSA-N
Canonical SMILES
CC1=CCCC2(C(O2)C3C(CC1)C(=C)C(=O)O3)C
Isomeric SMILES
C/C/1=C\CC[C@@]2([C@H](O2)[C@@H]3[C@@H](CC1)C(=C)C(=O)O3)C
Solubility ( literature )

DMSO (100 mg/ml), Ethanol (20 mg/ml), Dichloromethane.

Compound Classification
  • sesquiterpene lactone

MAP kinase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Other vendors may recommend +2 to +8°C storage.
Retest time
3 Years
Applications

Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Antibiotics
Research field: Cancer
Protein kinase related
Research field: Signal Transduction
Signal to sort
P

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Parthenolide.gif
Parthenolide.gif

Paclitaxel (Taxol)

Paclitaxel (Taxol)
Molecular Formula
C47H51NO14
M.W.
853.90
CAS number
33069-62-4
Source
Taxus brevifolia ( a plant extract)
Fermentek product Code
PAC-001
Brand/grade
For research
Appearance
White crystalline solid.
Purity by HPLC
≥ 98% ; refer to CoA for more data
Melting point
200°C to 220°C (decomposition)
Solubility test
Clear colorless solution at 50mg/ml of Methanol.
Names and identifiers

RTECS: DA8340700

EU number
608-826-9
Description

Paclitaxel (taxol) is an antineoplastic agent from a plant extract.

Paclitaxel  (taxol) stabilizes microtubules in their polymerized form thus leading to cell death

InChl Key
RCINICONZNJXQF-MZXODVADSA-N
Canonical SMILES
CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Isomeric SMILES
CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)OC(=O)C
Solubility ( literature )

DMSO, Methanol, Ethanol. Unstable in Methanol.

Compound Classification
  • Cyclodecane
  • Antitumor agent.
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

A antineoplastic drug. A tool in Microtubuli research

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Fermentek Product Category
Plant-derived
Research field: Cancer
Angiogenesis related
Research field: Signal Transduction
Signal to sort
P

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Paclitaxel__Taxol_.gif
Paclitaxel__Taxol_.gif

Oligomycin B

Oligomycin B
Molecular Formula
C45H72O12
M.W.
805.05
CAS number
11050-94-5
Source
Streptomyces diastatochromogenes
Fermentek product Code
OLB-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Melting point
160°C-175°C
Solubility test
Clear colorless solution at 5 mg/ml Methanol
Names and identifiers

Oligomycin B

Oligomycin A, 28-oxo-

EU number
234-275-5
Description

Oligomycin B: a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase.

Oligomycin B product from Fermentek is practically free of homologs.

InChl Key
QPRQJOHKNJIMGN-UXAQBZNTSA-N
Canonical SMILES
CCC1CCC2C(C(C(C3(O2)C(=O)CC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Isomeric SMILES
CC[C@H]/1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)C(=O)C[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Acetone

Compound Classification

macrolideATPase inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

Used as a tool in cytochemistry

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Ingredient type
Fermentek product
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Signal Transduction
Others
Signal to sort
O

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Oligomycin_B.gif
Oligomycin_B.gif

Oligomycin A

Oligomycin A
Molecular Formula
C45H74O11
M.W.
791.06
CAS number
579-13-5
MSDS
Source
Streptomyces diastatochromogenes
Fermentek product Code
OLA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
148°C-152°C
Solubility test
Clear colorless solution at 10 mg/ml Methanol or Dichloromethane
Names and identifiers

 

EINECS 209-437-3

RTECS: RK3328000

EU number
209-437-3
Description

Oligomycin A: a macrolide antibiotic that inhibits membrane bound mitochondrial ATPase. Practically free of homologs

InChl Key
MNULEGDCPYONBU-WMBHJXFZSA-N
Canonical SMILES
CCC1CCC2C(C(C(C3(O2)CCC(C(O3)CC(C)O)C)C)OC(=O)C=CC(C(C(C(=O)C(C(C(C(=O)C(C(C(CC=CC=C1)C)O)(C)O)C)O)C)C)O)C)C
Isomeric SMILES
CC[C@H]\1CC[C@@H]2[C@@H]([C@@H]([C@H]([C@@]3(O2)CC[C@H]([C@H](O3)C[C@H](C)O)C)C)OC(=O)/C=C/[C@H]([C@@H]([C@H](C(=O)[C@H]([C@@H]([C@H](C(=O)[C@@]([C@@H]([C@H](C/C=C/C=C1)C)O)(C)O)C)O)C)C)O)C)C
Solubility ( literature )

Dichloromethane, DMSO, Ethanol, Acetone

Compound Classification

macrolideATPase inhibitor

Retest time
3 Years
Applications

Used as a tool in cytochemistry

Disclaimer
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Research field: Signal Transduction
Others
Signal to sort
O

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Oligomycin_A.gif
Oligomycin_A.gif

Okadaic Acid

Okadaic Acid
Molecular Formula
C44H68O13
M.W.
805.00
CAS number
78111-17-8
Source
Marine dinoflagellates
Fermentek product Code
OKA-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml EtOH;
Clear colorless solution at 40mg/ml DMSO
Names and identifiers

RTECS AA8227800

EU number
616-589-8
Chemical name
Acanthifolicin, 9,10-deepithio-9,10-didehydro-
Description

Inhibitor of protein phosphatase

InChl Key
QNDVLZJODHBUFM-WFXQOWMNSA-N
Canonical SMILES
CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O
Isomeric SMILES
C[C@@H]1CC[C@]2(CCCCO2)O[C@@H]1[C@@H](C)C[C@@H]([C@@H]3C(=C)[C@H]([C@H]4[C@H](O3)CC[C@]5(O4)CC[C@@H](O5)/C=C/[C@@H](C)[C@@H]6CC(=C[C@@]7(O6)[C@@H](CC[C@H](O7)C[C@](C)(C(=O)O)O)O)C)O)O
Solubility ( literature )

Reportedly, Okadaic acid is soluble in acetone, methanol, ethanol, chloroform or ethyl acetate.

Compound Classification

Polyether antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Applications

Okadaic Acid is a potent non-TPA type tumor promoter and vasodilator. It induces hyperphosphorylation of the P53 oncoprotein

Ingredient type
Fermentek product
Available since
Title
Additional Transport Information:
Value
De Minimis Quantities exemption, per IATA 2.6.10 - applicable.
Title
Transpoprt information
Value
Pg III
Title
Storage considerations
Value
Some other sources recommend storing under inert gase
Fermentek Product Category
Research field: Cancer
Apoptosis related
Protein kinase related
DNA replication inhibitors
Research field: Signal Transduction
Others
Signal to sort
O

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Okadaic_Acid.gif
Okadaic_Acid.gif

Myriocin

Myriocin
Molecular Formula
C21H39NO6
M.W.
401.54
CAS number
35891-70-4
MSDS
Source
Mycelia sterilia (fungus)
Fermentek product Code
MYR-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥95% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
164°C-184°C
Solubility test
Clear colorless solution at 2mg/ml of Methanol (slight heating),
Clear colorless solution at 5mg/ml of DMSO (slight heating)
Names and identifiers
  • Myriocin
  • Thermozymocidin,
  • ISP-I
  • (2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic acid
EU number
636-862-5
Description

Fungal antibiotic, atypic amino acid, immunomodulator, serine palmitoyltransferase inhibitor, apoptosis inducer.

InChl Key
ZZIKIHCNFWXKDY-GNTQXERDSA-N
Canonical SMILES
CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O
Isomeric SMILES
CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
Solubility ( literature )

Myriocin is slightly soluble in DMSO, alcohols.Myriocin is insoluble in water and in most organic solvents.

Compound Classification
  • amino-acid antibiotic
  • immunosupressor
  • serine palmitoyltransferase inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Open carefully.
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Myriocin, a potent inhibitor of serine palmitoyltransferase,a (the 1st step in sphingosine biosynthesis), is used in biochemical research as a tool for depleting cells of sphingolipids. Myriocin is a potent immunosuppressor, reportedly 10 to 100 times stronger than cyclosporin.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Shipped at ambient temperature
Transport safety: class 6.1 PG III
Available since
Title
Toxicity oral mouse LD50
Value
300 miligram/kg
Fermentek Product Category
Mycotoxins
Antibiotics
Enzyme-inhibitors
Immunomodulators
Research field: Signal Transduction
Signal to sort
M

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Myriocin.gif
Myriocin.gif

Leptomycin B

Leptomycin B
Molecular Formula
C33H48O6
M.W.
540.70
CAS number
87081-35-4
Source
Streptomyces sp.
Fermentek product Code
LPB-001
Brand/grade
For research
Appearance
Lyophilized powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 10mg/ml of Methanol
Names and identifiers

Synonyms: 

  • Elactocin
  • Mantuamycin
  • Antibiotic CI 940
  • Antibiotic CL 1957A

RTECS:      RA5390000

EU number
617-954-4
Description

Leptomycin B is an unsaturated, branched-chain fatty acid.

Until 4-jun-2018 Leptomycin had been offered by Fermentek in the form of 1% V/W solution in Methanol/Water mix. Since then, it is offered as lyophylizate.

InChl Key
YACHGFWEQXFSBS-XYERBDPFSA-N
Canonical SMILES
CCC(=CC(C)CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=CC1C(C=CC(=O)O1)C
Isomeric SMILES
CC/C(=C/[C@H](C)C/C=C/C(=C/[C@@H](C)C(=O)[C@@H](C)[C@@H]([C@@H](C)C/C(=C/C(=O)O)/C)O)/C)/C=C/[C@H]1[C@H](C=CC(=O)O1)C
Solubility ( literature )

Leptomycin B is soluble in ethanol, methanol.

Until 4-jun-2018, Fermentek supplied Leptomycin in form of 1% w/v solution in Methanol/water. Since 4-jun-2018 it is as a lyophylisate. 

Compound Classification

Fatty acid antibiotic

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Retest time
2 Years
Applications

Leptomycin B is an important tool in the study of nuclear export. Leptomycin B is twice as potent as Leptomycin A Leptomycin B (LPB) was originally discovered as a potent anti-fungal antibiotic from Streptomyces sp. However, recent data (2003) showed that Leptomycin causes G1 cell cycle arrest in mammalian cells and is a potent anti-tumor agent against murine experimental tumors. Leptomycin B is a potent and specific nuclear export inhibitor. Leptomycin B alkylates and inhibits CRM1 (chromosomal region maintenance)/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). In addition to antifungal and antibacterial activities, Leptomycin B blocks the cell cycle and is a potent anti-tumor agent. At low nM concentrations, Leptomycin B blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB, and it stabilizes the expression of p53. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers
Value
94730-69-5
Title
Change notif 4-jun-2018
Value
Supplied as lyophilisate
Title
comments: safety
Value
The info regarding toxicity/flammability is about the methanol. We offer solid material.
Fermentek Product Category
Research field: Cancer
Protein synthesis inhibitors
Anti Fungal
Cancer Related Compounds
Research field: Signal Transduction
Others
Signal to sort
L

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Leptomycin_B.gif
Leptomycin_B.gif

KT5823

KT5823
Molecular Formula
C29H25N3O5
M.W.
495.53
CAS number
126643-37-6
Source
Semisynthetic
Fermentek product Code
KT5-002
Brand/grade
For research
Appearance
White solid
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless solution at 5mg/ml Ethyl acetate
EU number
603-150-0
Description

KT5823 is a potent, selective inhibitor of cGMP-dependent protein kinase (PKG)

InChl Key
QTYMDECKVKSGSM-UHFFFAOYSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CN(C6=O)C)(C(=O)OC)OC
Solubility ( literature )

DMSO, Ethyl Acetate

Compound Classification

indolocarbazole alkaloidPKG inhibitor

Storage, handling
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Applications

KT5823 induces apoptotic fragmentation of DNA

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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KT5823.gif
KT5823.gif

KT5720

KT5720
Molecular Formula
C32H31N3O5
CAS number
108068-98-0
Source
Synthetic
Fermentek product Code
KT5-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
145°C-155°C
Solubility test
Clear colorless solution at 5mg/ml Methanol
EU number
810-587-2
Description

KT5720: A selective inhibitor of cAMP-dependent protein kinase (PKA)

InChl Key
ZHEHVZXPFVXKEY-UHFFFAOYSA-N
Canonical SMILES
CCCCCCOC(=O)C1(CC2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)C1(O2)C)CNC6=O)O
Isomeric SMILES
CCCCCCOC(=O)[C@]1(C[C@H]2N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N(C7=C53)[C@@]1(O2)C)CNC6=O)O
Solubility ( literature )

Soluble in methanol, DMSO

Compound Classification

indolocarbazole alkaloid

PKA inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Avoid exposing to strong direct light.
Other vendors may recommend higher temperatures for storage.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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KT5720.gif
KT5720.gif

K252c

K252c
Molecular Formula
C20H13N3O
M.W.
311.40
CAS number
85753-43-1
Source
Nocardiopsis sp
Fermentek product Code
K2C-001
Brand/grade
For research
Appearance
Off-white to yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear colorless to light yellow solution at 7.8mg/ml DMSO (25mM)
Names and identifiers

Synonyms:

  • Staurosporine aglycone;
  • Staurosporinone.
  • K252C

 

Description

K252c: Cell permeable protein kinase inhibitor of the Staurosporine family (indolo[2,3-a]carbazole alkaloids)

InChl Key
MEXUTNIFSHFQRG-UHFFFAOYSA-N
Canonical SMILES
C1C2=C3C4=CC=CC=C4NC3=C5C(=C2C(=O)N1)C6=CC=CC=C6N5
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;Soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol;Insoluble in water, 2-propanol. Comment: This information has been collected from available scientific sources. It is not a part of product specification

Compound Classification

indolocarbazole alkaloidPKC inhibitor

Storage, handling
-20oC. Protect from light. Hygroscopic. Protect from moisture
Retest time
3 Years
Applications

K252c inhibits protein kinase C. Its reported IC50 value of 214 nM on rat brain enzyme K252c is cytotoxic for A549 and P388 cancer celllines showing IC50 = 2-3 μM

Ingredient type
Fermentek product
Available since
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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K252c.gif
K252c.gif
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