In higher (multicellular) organisms, many processes are required for coordinating individual cells to act as parts of the whole. Among these we may count attraction of spermatozoides by ovum, environment sensing in general, cellular response to hormones and neuro transmitters, initiating and terminating cells multiplication, or imposing apoptosis on unneeded cells during ontogenesis.

Usually, Signal-Transduction would begin with binding of the singnal-molecule to a receptor on the cell-membrane, altering its configuration and thus starting a chain of reactions within the cell. These reactions may include (de)acetylations, (de)/phosphorilations on the participating molcules.

The Signal Transduction related reagents may by further classified as

  • Ca++-ATPase inhibitors, such as Artemisinin, Cyclopiazonic acid, Thapsigargin, Paxilline
  • SERCA Ca2+-ATPase stimulator/ activator, such as Ochratoxin A
  • Hedgehog signalling inhibitors: Cyclopamine

 

K252b

K252b
Molecular Formula
C26H19N3O5
M.W.
453.45
CAS number
99570-78-2
Source
Semisynthetic
Fermentek product Code
K2B-001
Brand/grade
For research
Appearance
white to light yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
245°C-255°C
Solubility test
Clear colorless solution at 5mg/ml of Methanol
Names and identifiers

Synonyms:

  • Antibiotic K 252b
  • K 252b
  • KT 5556

 

 

 

Description

K252B: an inhibitor of protein kinase A, C, G

InChl Key
AMSOPBXQXSAAAC-PLZPTFKGSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Isomeric SMILES
C[C@@]12[C@](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O
Solubility ( literature )

DMSO or Methanol

Compound Classification

Indolocarbazole alkaloid; 

PK inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Protect from light !
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Deleted CAS Numbers:
Value
107028-51-3
Title
Transport information
Value
NDG
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Apoptosis related
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
K252b.gif
K252b.gif

K252a

K252a
Molecular Formula
C27H21N3O5
M.W.
467.47
CAS number
99533-80-9
Source
Nocardiopsis sp
Fermentek product Code
K2A-001
Brand/grade
For research
Appearance
White to pale yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
255°C-270°C
Solubility test
Clear colorless to slight yellow solution at 50mg/ml of DMSO
Names and identifiers

RTECS NZ0550000

EU number
640-127-4
Description

K252a: Cell permeable protein kinase inhibitor

InChl Key
KOZFSFOOLUUIGY-IYYJOCMQSA-N
Canonical SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Isomeric SMILES
C[C@]12[C@@](C[C@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)OC)O
Solubility ( literature )

Readily soluble in chloroform, acetonitrile, acetone, dioxane, tetrahydrofuran, pyridine;soluble in ethanol, methanol, 1-propanol, ethyl acetate and n-butanol; insoluble in water, 2-propanol

Compound Classification
  • indolocarbazole alkaloid
  • PK inhibitor
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Protect from moisture
Protect from light !
Use the original container to store the product.
Keep the lid tightly closed.
Retest time
3 Years
Applications

K252a is a highly potent cell permeable inhibitor of CaM kinase and phosphorylase kinase . At high concentrations it also inhibitors of serine/threonine protein kinases. K252a inhibits tyrosine phosphorylation of Trk A induced by NGF K252a is reported to promote myogenic differentiation in C2 mouse myoblasts

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Title
Deleted CAS Numbers
Value
97161-97-2; 105450-17-7; 108645-76-7; 151004-74-9
Title
Transport information
Value
Not hazardous for transport
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Others
Signal to sort
K

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Price
$1.00
K252a.gif
K252a.gif

Cyclopiazonic acid

Cyclopiazonic acid
Molecular Formula
C20H20N2O3
M.W.
336.38
CAS number
18172-33-3
Source
Penicillium griseofulvum
Fermentek product Code
CPA-001
Brand/grade
For research
Appearance
Off white to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear bright yellow solution at 10mg/ml Dichloromethane; Clear bright yellow solution at 100mM DMSO
Names and identifiers

RTECS: UY8587000

EU number
634-041-6
Description

Cyclopiazonic acid (aka CPA) is a toxic compound of indole tetramic acid group. This mycotoxin is produced by Penicillium and Aspergillus fungi.  CPA inhibits SERCA (sarcoplasmic or endoplasmic reticulum calcium-dependent ATPase and thus interferes with the muscle contraction-relaxation cycle.

InChl Key
SZINUGQCTHLQAZ-UHFFFAOYSA-N
Canonical SMILES
CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O
Solubility ( literature )

DMSO, Methylene Chloride and Methanol.

Compound Classification

Bioactivity:

  • tremorgen mycotoxin
  • vasodilator
  • endoplasmic reticulum inhibitor
Storage, handling
-20°C.
Retest time
3 Years
Applications

Cyclopiazonic acid is a reversible inhibitor of endoplasmic reticulum Ca++ATPase

Ingredient type
Fermentek product
Available since
Title
TSE
Value
F
Title
sig
Value
239805
Title
Transport information
Value
PG II
Fermentek Product Category
Food Safety
Mycotoxins
Food Safety Related
Research field: Signal Transduction
Signal to sort
C

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Price
$1.00
Cyclopiazonic_Acid.gif
Cyclopiazonic_Acid.gif

Cordycepin

Cordycepin
Molecular Formula
C10H13N5O3
M.W.
251.24
CAS number
73-03-0
Source
Cordyceps militaris
Fermentek product Code
COR-001
Brand/grade
For research
Appearance
White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
220°C-230°C
Solubility test
Clear colorless solution at 25mg/ml DMSO
Names and identifiers

Systematic name:
3'-Deoxyadenosine

RTECS:
AU7358610;

EU number
200-791-4
Description

Adenosine analog which occurs naturally in Cordyceps militaris, a mushroom known in traditional medicine.

InChl Key
OFEZSBMBBKLLBJ-BAJZRUMYSA-N
Canonical SMILES
C1C(OC(C1O)N2C=NC3=C2N=CN=C3N)CO
Isomeric SMILES
C1[C@H](O[C@H]([C@@H]1O)N2C=NC3=C2N=CN=C3N)CO
Solubility ( literature )

Cordycepin is soluble in water, methanol, ethanol, DMSO

Compound Classification

Natural Nucleoside antibiotic.

Purine nucleoside

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Retest time
3 Years
Applications

Cordycepin inhibits growth of various tumor cells in vitro. It may be converted to 3'-deoxyadenosine triphosphate , thus inhibiting ATP-dependent DNA synthesis. Cordycepin is used in the study of messenger RNA transcription.

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
CN code
Value
29419000
Fermentek Product Category
Research field: Cancer
Research field: Signal Transduction
Others
Signal to sort
C

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Price
$1.00
Cordycepin.gif
Cordycepin.gif

Chelerythrine chloride

Chelerythrine chloride
Molecular Formula
C21H18NO4∙Cl
M.W.
383.82
CAS number
3895-92-9
Source
Chelidonium majus
Fermentek product Code
CHE-001
Brand/grade
For research
Appearance
Yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
202°C-208°C
Solubility test
Clear yellowish solution at 5mg/ml Methanol
Names and identifiers

EINECS 223-444-9

1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride

Chelerythrine hydrochloride

EU number
223-444-9
Description

Chelerythrine: A benzophenanthridine alkaloid. A potent, selective, and cell-permeable PKC inhibitor.Chelerythrine is very closely related to sanguinarine. Unlike sanguinarine which is found in the green biomass of Chelidonium, Chelerythrine mainly occurs in its roots.

InChl Key
WEEFNMFMNMASJY-UHFFFAOYSA-M
Canonical SMILES
C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-]
Solubility ( literature )

Methanol, Water, DMSO

Compound Classification

Benzophenanthridine alkaloid

PKC inhibitor

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Retest time
3 Years
Ingredient type
Fermentek product
Available since
Title
Oral Toxicity Mouse
Value
No data.
Title
Transport safety information
Value
Not hazardous for transport
Fermentek Product Category
Plant-derived
Enzyme-inhibitors
Protein kinase related
Research field: Signal Transduction
Signal to sort
C

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Price
$1.00
Chelerythrine_Chloride.gif
Chelerythrine_Chloride.gif

Apicidin

Apicidin
Molecular Formula
C34H49N5O6
M.W.
623.80
CAS number
183506-66-3
Source
Fusarium sp.
Fermentek product Code
API-001
Brand/grade
For research
Appearance
White to Off-White powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
187°C-193°C
Solubility test
Clear colorless solution at 1 mg /ml Ethanol or DMSO
Names and identifiers

Synonyms:

  • apicidin C

IUPAC name:

  • (3S,6S,9S,12R)-3-[(2S)-butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone

RTECS XJ6094046 

EU number
635-755-0
Description

Apicidin is a mycotoxin which may occur naturally, as a result of Fusarium fungi growing on improperly stored foods.

Apicidin is a potent cell permeable inhibitor of histone deacetylase.

 

InChl Key
JWOGUUIOCYMBPV-GMFLJSBRSA-N
Canonical SMILES
CCC(C)C1C(=O)N2CCCCC2C(=O)NC(C(=O)NC(C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Isomeric SMILES
CC[C@H](C)[C@H]1C(=O)N2CCCC[C@@H]2C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)CC3=CN(C4=CC=CC=C43)OC)CCCCCC(=O)CC
Solubility ( literature )

Ethanol, DMSO, Dichloromethane. Slightly soluble in water, methanol.

Compound Classification
  • Cyclic peptide antibiotic
  • Mycotoxin
  • Antiprotozoal
  • HDAC inhibitor
  • Angiogenesis inhibitor
Retest time
3 Years
Applications

Cyclic peptide antibiotic with broad spectrum antiparasitic and antiprotozoan activity. An histone deacetylase inhibitor, Anti-angiogenic; Apoptosis inductor.

Disclaimer
Refer to MSDS for further safety and handling instructions.
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Not hazardous for transport
Title
research fields
Value
Systemic lupus erythematosus; Autoimmune diseases; Rheumatoid arthritis; Histone deacetylation;
Title
Safety comments
Value
RTECS only specifies mutagenity. Whoever says it is toxic, has no data to support
Fermentek Product Category
Antibiotics
Cytotoxic agents
Enzyme-inhibitors
Research field: Cancer
Angiogenesis related
Apoptosis related
Anti Protozoal
Research field: Signal Transduction
Ionophores
Others
Signal to sort
A

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Price
$1.00
Apicidin.gif
Apicidin.gif

Alamethicin

Alamethicin
Molecular Formula
C92H150N22O25
M.W.
1 964.30
CAS number
27061-78-5
MSDS
Source
Trichoderma viride
Fermentek product Code
ALA-001
Brand/grade
For research
Appearance
Off White to Beige powder
Purity by HPLC
4 peaks, complies to standard
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
252°C-272°C
Solubility test
Clear colorless solution at 10mg/ml DMSO or Methanol
Names and identifiers

 

Synonyms: Antibiotic U 22324

RTECS: AY1900000

EU number
608-040-6
Description

Alamethicin is a channel-forming ionophore. Chemically, it is a peptide of 20 amino acids. The product consists of a mixture of several isoforms, which may be slightly different in the amino-acids sequences, but possess the same activity.

 

InChl Key
LGHSQOCGTJHDIL-UTXLBGCNSA-N
Canonical SMILES
CC(C)CC(C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CC2=CC=CC=C2)CO)NC(=O)CNC(=O)C(C)(C)NC(=O)C(C(C)C)NC(=O)C(C)(C)NC(=O)C(CCC(=O)N)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C(C)NC(=O)C(C)(C)NC(=O)C3CCCN3C(=O)C(C)(C)NC(=O)C
Isomeric SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)N)C(=O)NC(C)(C)C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NC(C)(C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC2=CC=CC=C2)CO)NC(=O)C(C)(C)NC(=O)[C@H](C)NC(=O)C(C)(C)NC(=O)[C@@H]3CCCN3C(=O)C(C)(C)NC(=O)C
Solubility ( literature )

DMSO, Methanol, Ethanol

Compound Classification
  1. Peptide antibiotic
  2. Channel forming Ionophore
Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Applications

Can mimic nerve action potential across artificial membranes

Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Ingredient type
Fermentek product
Available since
Title
Transport information
Value
Pg III
Title
Deleted CAS numbers
Value
11051-59-5; 55739-76-9
Fermentek Product Category
Antibiotics
Enzyme-inhibitors
Research field: Cancer
Anti Bacterial
Research field: Signal Transduction
Ionophores
Signal to sort
A

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Price
$1.00
Alamethicin
Alamethicin

7-Amino-Actinomycin D (7-AAD)

7-Amino-Actinomycin D (7-AAD)
Molecular Formula
C62H87N13O16
M.W.
1 270.43
CAS number
7240-37-1
MSDS
Source
Semisynthetic Derivate of Actinomycin D
Fermentek product Code
7AD-001
Brand/grade
For research
Appearance
Purple powder
Purity by HPLC
≥97% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Melting point
235°C-255°C
Solubility test
Clear purple solution at 20mg/ml DMSO
Names and identifiers

IUPAC name:
2,7-Diamino-N,N'-bis[(6S,9R,10S,13R,18aS)-6,13-diisopropyl-2,5,9-trimethyl-1,4,7,11,14-pentaoxohexadecahydro-1H-pyrrolo[2,1-i][1,4,7,10,13]oxatetraazacyclohexadecin-10-yl]-4,6-dimethyl-3-oxo-3H-phenox azine-1,9-dicarboxamide

RTECS: 

AU1579000

 

EU number
635-285-6
Chemical name
7-Amino-Actinomycin-D
Description

(7-AAD) 7-Amino-Actinomycin-D is produced synthetically from natural Actinomycin D. (7-AAD) 7-Amino-Actinomycin-D binds to single stranded DNA. it is used, as a fluorescent dye, as a reagent capable to distinguish dead and live cells.

InChl Key
YXHLJMWYDTXDHS-UHFFFAOYSA-N
Canonical SMILES
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)C)N
Solubility ( literature )

Dichloromethane, DMSO, Methanol. Slightly soluble in water

Storage, handling
Store in a freezer upon arrival, at -10°C to -25°C
Hygroscopic substance.
Protect from moisture
Use the original container to store the product.
Keep the lid tightly closed.
Avoid exposing to strong direct light.
Retest time
3 Years
Disclaimer
For Research use only
Not for Human or Drug use
Not extracted from humans or animals
Refer to MSDS for further safety and handling instructions
Semi-Synthetic
Ingredient type
Fermentek product
Transport safety: class 6.1 PG II
Available since
Title
Transport information
Value
Pg II
Fermentek Product Category
Antibiotics
Research field: Cancer
Apoptosis related
Anti Tumor agents
DNA replication inhibitors
Research field: Signal Transduction
Signal to sort
A

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Price
$1.00
7-_Amino-Actinomycin_D
7-_Amino-Actinomycin_D
Subscribe to Research field: Signal Transduction