Cyclopiazonic acid
Molecular Formula
C20H20N2O3
M.W.
336.38
CAS number
18172-33-3
Details
Source
Penicillium griseofulvum
Fermentek product Code
CPA-001
Brand/grade
For research
Specifications
Appearance
Off white to faint yellow powder
Purity by HPLC
≥98% ; refer to CoA for more data
Purity By TLC
≥98% ; refer to CoA for more data
Solubility test
Clear bright yellow solution at 10mg/ml Dichloromethane; Clear bright yellow solution at 100mM DMSO
Chemical identification
Names and identifiers
RTECS: UY8587000
EU number
634-041-6
Description
Cyclopiazonic acid (aka CPA) is a toxic compound of indole tetramic acid group. This mycotoxin is produced by Penicillium and Aspergillus fungi. CPA inhibits SERCA (sarcoplasmic or endoplasmic reticulum calcium-dependent ATPase and thus interferes with the muscle contraction-relaxation cycle.
InChl Key
SZINUGQCTHLQAZ-UHFFFAOYSA-N
Canonical SMILES
CC(=O)C1=C(C2C3C(CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O
Further Information
Solubility ( literature )
DMSO, Methylene Chloride and Methanol.
Compound Classification
Bioactivity:
- tremorgen mycotoxin
- vasodilator
- endoplasmic reticulum inhibitor
Storage, handling
-20°C.
Retest time
3 Years
Applications
Cyclopiazonic acid is a reversible inhibitor of endoplasmic reticulum Ca++ATPase
Composition
Ingredient type
Fermentek product
Special Info
Available since
Other Fields
Title
TSE
Value
F
Title
sig
Value
239805
Title
Transport information
Value
PG II
Fermentek Product Category
Signal to sort
C
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