Cyclopiazonic acid (aka CPA) is a toxic compound of indole tetramic acid group. This mycotoxin is produced by Penicillium and Aspergillus fungi. CPA inhibits SERCA (sarcoplasmic or endoplasmic reticulum calcium-dependent ATPase and thus interferes with the muscle contraction-relaxation cycle.
DMSO, Methylene Chloride and Methanol.
- tremorgen mycotoxin
- endoplasmic reticulum inhibitor
Cyclopiazonic acid is a reversible inhibitor of endoplasmic reticulum Ca++ATPase